2008
DOI: 10.1016/j.toxlet.2008.03.003
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A 28-day oral dose toxicity study in Wistar rats enhanced to detect endocrine effects of decabromodiphenyl ether (decaBDE)

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Cited by 56 publications
(37 citation statements)
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“…There is increasing evidence that BDE-209, which is contained in decaBDE, is persistent, bioaccumulative, and might be debrominated to lowerbrominated BDEs (Stapleton et al, 2004;He et al, 2006;Kierkegaard et al, 2007;Van den Steen et al, 2007;Schenker et al, 2008). In addition, the scientific discussion about toxic effects of BDE-209 is ongoing (Viberg et al, 2003;Van der Ven et al, 2008).…”
Section: Congener Patternmentioning
confidence: 99%
See 1 more Smart Citation
“…There is increasing evidence that BDE-209, which is contained in decaBDE, is persistent, bioaccumulative, and might be debrominated to lowerbrominated BDEs (Stapleton et al, 2004;He et al, 2006;Kierkegaard et al, 2007;Van den Steen et al, 2007;Schenker et al, 2008). In addition, the scientific discussion about toxic effects of BDE-209 is ongoing (Viberg et al, 2003;Van der Ven et al, 2008).…”
Section: Congener Patternmentioning
confidence: 99%
“…In addition, the EPA announced the phase-out of decaBDE in December 2009 for the end of 2013 (USEPA, 2009). In Europe the use of decaBDE is still permitted for all appliances except for electric and electronic equipment (BSEF, 2009), but the scientific discussion about the toxicity of decaBDE is ongoing (Viberg et al, 2003;Van der Ven et al, 2008). Effects of PBDEs in animal models include endocrine disruption, neurodevelopmental and behavioural effects, hepatic abnormalities, and possibly cancer (McDonald, 2002;Birnbaum and Staskal, 2004;Darnerud, 2008).…”
Section: Introductionmentioning
confidence: 99%
“…The BDE and MeO-BDE standards were purchased from Wellington Laboratories (Ontario, Canada). BDE mixture standards include 27 BDE congeners (BDE3, 7,15,17,28,47,49,66,71,77,85,99,100,119,126,138,153,154,156,183,184,191,196,197,206,207,209). MeO-BDE mixture standards include four tetra-MeOBDEs and four penta-MeO-BDEs: 2,2′,4,4′-tetrabromo-5-methoxydiphenyl ether (5-MeO-BDE47), 2,2′,4,4′-tetrabromo-6-methoxydiphenyl ether (6-MeO-BDE47), 2,2′,4,5′-tetrabromo-4′-methoxydiphenyl ether (4′-MeO-BDE49), 2,3′,4,5′-tetrabromo-2′-methoxydiphenyl ether (2′-MeO-BDE68), 2,2′,4,4′,5-pentabromo-5′-methoxydiphenyl ether (5′-MeO-BDE99), 2,2′,4,4′,6-pentabromo-5′-methoxydiphenyl ether (5′-MeO-BDE100), 2,2′,4,5,5′-pentabromo-4′-methoxydiphenyl ether (4′-MeO-BDE101), and 2,2′,4,5′,6-pentabromo-4′-methoxydiphenyl ether (4′-MeO-BDE103).…”
Section: Standards and Reagentsmentioning
confidence: 99%
“…In addition, the toxicokinetics of BDE47, BDE99, BDE100, BDE153 and BDE154 were also studied in rats and mice, and the results demonstrated that lipophilic tissues were the preferred uptake sites [16]. The toxicity study of BDE209 in rats with oral administration suggested that BDE209 was hazardous to reproductive health [17]. Overall, most of these studies focused on the toxicokinetics of BDEs in mammals, however, little information was available on the toxicokinetics of BDEs in fish.…”
Section: Introductionmentioning
confidence: 99%
“…Though BDE-209 has long been believed to be only minimally toxic, there is growing evidence that it can cause endocrine effects Tseng et al, 2008;Van der Ven et al, 2008), induce neurotoxic effects and result in cognitive deficiencies, especially for the neonates after prenatal and postnatal exposure to BDE-209 (Onos et al, 2007;Viberg et al, 2003Viberg et al, , 2007. For example, BDE-209 can increase the expression of hepatic CYP1A and CYP2B in male rats and decrease activity of CYP17 in female rats, which may result in hazard for reproductive health (Van der Ven et al, 2008).…”
Section: Introductionmentioning
confidence: 99%