A 24-week randomized clinical trial investigating the efficacy and safety of two doses of etanercept in nail psoriasis

Ortonne, Jean‐Paul; Paul, C.; Berardesca, Enzo; Marino, Valentina; Gallo, Gaia; Brault, Y.; Germain, Jean-Michel

doi:10.1111/bjd.12060

Cited by 82 publications

(54 citation statements)

References 35 publications

(135 reference statements)

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“…In the same study,patients treated with cyclosporine showed a 37% mean improvement in the NAPSI score (21 (25). The efficacy of etanercept in nail psoriasis has also been supported by other studies (7,26,27). In our case, there was a rapid response to etanercept with a significant reduction in the NAPSI score.…”

Section: Case Reportsupporting

confidence: 83%

Therapeutic challenges in a case of psoriasis with nail onset

Mitran¹,

Mitran²,

Sârbu³

et al. 2017

J Mind Med Sci.

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Nail psoriasis affects a large number of patients with psoriasis and has a major psychosocial impact. Furthermore, it may be regarded as a predictor of more severe forms of psoriasis and early sign of psoriatic arthritis. The clinical presentations vary depending on the structure affected (nail matrix or nail bed), the nail lesions may range from minor to severe, but they are not specific. Treatment is a challenge, in most cases the lesions being resistant to therapy. We present a rare case of psoriasis with nail onset in a 59-year-old woman. The nail involvement confined to the fingernails was severe, with significant impairment of the patient's quality of life. Conventional therapies failed to improve the nail lesions, but a marked improvement was achieved under etanercept therapy.Acne conglobata is a rare, severe form of acne vulgaris characterized by the presence of comedones, papules, pustules, nodules and sometimes hematic or meliceric crusts, located on the face, trunk, neck, arms and buttocks. Case ReportWe report the case of a 16 year old Caucasian female patient from the urban area who addressed our Mădălina I. Mitran et al.

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Section: Case Reportsupporting

confidence: 83%

Therapeutic challenges in a case of psoriasis with nail onset

Mitran¹,

Mitran²,

Sârbu³

et al. 2017

J Mind Med Sci.

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“…Eine retrospektive Analyse der EXPRESS Studie zeigte, dass bei einjähriger Nachbeobachtung von 186 Patienten mit anfänglich positivem Ansprechen auf Infliximab nachhaltig verbesserte PASI-, DLQIund NAPSI-Werte auch noch nach der 50. Ortonne et al untersuchten Wirksamkeit, Sicherheit und Verbesserungen mit zwei Etanercept-Dosierungen bei Patienten mit mittelschwerer bis schwerer Psoriasis und Nagelbeteiligung [15]. Damit wurde nachgewiesen, dass Infliximab Nagelveränderungen und die Lebensqualität verbessert und als äußerst geeignet für die Behandlung von NP anzusehen ist [2].…”

Section: Patienten Und Methodenunclassified

A 36‐week retrospective open trial comparing the efficacy of biological therapies in nail psoriasis

Bardazzi

Antonucci

Tengattini

et al. 2013

J Deutsche Derma Gesell

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“…There was a significant improvement in mean NAPSI scores at week 24 in both groups, with significant number of patients showing complete resolution. Both treatment regiments were found to be effective in nail psoriasis [60]. In the post hoc analysis of a RCT, in which the patients were randomized to receive either continuous (25 mg twice weekly for 54 weeks) or paused (50 mg twice weekly up to 12 weeks, followed by 25 mg twice weekly in case of relapse) etanercept therapy, 564 patients with nail involvement were evaluated.…”

Section: Biologic Treatmentsmentioning

confidence: 99%

Treatment of Nail Psoriasis: Common Concepts and New Trends

Oram

Akkaya

2013

Dermatology Research and Practice

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The lifetime incidence of nail involvement in psoriatic patients is estimated to be 80–90%, and the nails can be affected in 10% to 55% of psoriatic patients. Psoriasis may also solely involve the nails, without any other skin findings, in which the treatment can be more challenging. Nail psoriasis may lead to considerable impairment in quality of life due to aesthetic concerns and more importantly limitations in daily activities resulting from the associated pain, which may be overlooked by the physicians. Several topical and systemic treatment modalities, as well as radiation and light systems, have been used in the treatment of nail psoriasis. In the last decade, the introduction of biologic agents and the utilization of laser systems have brought a new insight into the treatment of nail psoriasis. This paper focuses on the recent advances, as well as the conventional methods, in treating nail psoriasis in adults and children, in reference to an extensive literature search.

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A 24-week randomized clinical trial investigating the efficacy and safety of two doses of etanercept in nail psoriasis

Abstract: Both ETN regimens were effective at treating nail psoriasis in this patient population.

Cited by 82 publications

References 35 publications

Therapeutic challenges in a case of psoriasis with nail onset

Therapeutic challenges in a case of psoriasis with nail onset

A 36‐week retrospective open trial comparing the efficacy of biological therapies in nail psoriasis

Treatment of Nail Psoriasis: Common Concepts and New Trends

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