A 24-month dietary carcinogenicity study of DAG (diacylglycerol) in rats

Chengelis, Christopher P.; Kirkpatrick, Jeannie B.; Bruner, Richard H.; Freshwater, Les; Morita, Osamu; Tamaki, Yasushi; Suzuki, Hiroyuki

doi:10.1016/j.fct.2005.06.006

Cited by 22 publications

(11 citation statements)

References 23 publications

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“…The variability in the organ weights was due to the presence of gross findings such as mass, atrophy, swollen, fibrosis, enlarged and hyperemia area [13]. After 24 months of MCP administration, no significant MCP-related difference was indicated from the relative organ weights of brain, heart, lungs, liver, spleen, kidneys, adrenal glands, testis and ovaries (Table 4).…”

Section: Resultsmentioning

confidence: 99%

A Chronic Oral Toxicity Study of Marine Collagen Peptides Preparation from Chum Salmon (Oncorhynchus keta) Skin Using Sprague-Dawley Rat

et al. 2011

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Due to the increased consumption of marine collagen peptides preparation (MCP) as ingredients in functional foods and pharmaceuticals, it was necessary to carry out safety requirements in the form of an oral chronic toxicity assessment. In order to define the oral chronic toxicity of MCP, a 24-month feeding study of MCP was carried out. Sprague-Dawley (S-D) rats at the age of four-week of both sexes were treated with MCP at the diet concentrations of 0%, 2.25%, 4.5%, 9% and 18% (wt/wt). The actual food intake and bodyweight of the individual animals were recorded periodically until sacrifice. Blood and urine samples were collected for serum chemistry evaluations and urinalysis. Throughout the experimental period, there was no toxicologically significant difference between the vehicle and MCP-treated animals with respect to the survival rate, body weight, food consumption, urinalysis, clinical biochemistry parameter and relative organ weight in either sex. Moreover, incidences of non-neoplastic lesions in MCP-treated groups did not significantly increase compared with the control group. Under the present experimental conditions, no higher risk of chronic toxic effects was observed in MCP-treated rats at the diet concentrations of 2.25%, 4.5%, 9% and 18% (wt/wt) than in the rats fed with basal rodent diet.

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Section: Resultsmentioning

confidence: 99%

A Chronic Oral Toxicity Study of Marine Collagen Peptides Preparation from Chum Salmon (Oncorhynchus keta) Skin Using Sprague-Dawley Rat

et al. 2011

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“…Thus, DG has been used in lieu of meals in favor of TG to control diabetes, prevention of arteriosclerosis and other diseases [16,17]. Additional research conducted on dietary effects of DG replacement therapy, as related to diet toxicity and carcinogenicity, in animals [18,19] and humans [20] have shown no negative side effects while still retaining the positive impacts described previously [21,22]. …”

Section: Introductionmentioning

confidence: 99%

Enzymatic Determination of Diglyceride Using an Iridium Nano-Particle Based Single Use, Disposable Biosensor

Hsu

Bartling

Wang

et al. 2010

Sensors

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A single use, disposable iridium-nano particle contained biosensor had been developed for the determination of diglyceride (DG). In this study hydrogen peroxide, formed through the enzymatic breakdown of DG via lipase, glycerol kinase and glycerol 3-phosphate oxidase, was electrochemically oxidized at an applied potential of +0.5 V versus the Ag/AgCl reference electrode. The oxidation current was then used to quantify the diglyceride concentration. Optimum enzyme concentrations and the surfactant loading used were established for successful sensor response. Good linear performance was observed over a DG concentration range of 0 to 25 μM in phosphate buffer and bovine serum media.

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“…Traul et al (2000) published an extensive revision on the toxicological properties of MCT in several animal species. Recently, Chengelis et al (2006aChengelis et al ( , 2006bChengelis et al ( , 2006c reported no toxicological effects of DAG (diacylglycerol) or TAG (triacylglycerol) oil in different animal models. However, concerning triheptanoin and its digestion products, included diheptanoin, no experimental studies are found in literature on the safety of their use in humans over an extended time.…”

Section: Introductionmentioning

confidence: 99%

Toxicological analysis of the chronic consumption of diheptanoin and triheptanoin in rats

Ataíde

Oliveira

Silva

et al. 2009

Int J of Food Sci Tech

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The aim of this study was to synthesise glycerol esters from heptanoic acid and to evaluate the toxicity of their chronic consumption in rats. The synthesised product (64% triheptanoin, 34% diheptanoin and 2% monoheptanoin) was called experimental oil. Newly weaned male Wistar rats (n = 3 · 10) were fed with control diet AIN-93, control with 30% substitution of soybean oil with experimental oil (TAGC 7 30%) or control with substitution of 50% (TAGC 7 50%), for 9 months. The experimental oil did not affect the growth, lipid digestibility or hepatic and renal function, and the lipid profile serum analysis. Additionally, it exhibited a hepato-protector effect in group TAGC 7 50%. In conclusion, the chronic consumption of di-and triheptanoin was not toxic in rats, suggesting that they may be used in the treatment of disorders in which more easily digestible lipids are required.

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A 24-month dietary carcinogenicity study of DAG (diacylglycerol) in rats

Cited by 22 publications

References 23 publications

A Chronic Oral Toxicity Study of Marine Collagen Peptides Preparation from Chum Salmon (Oncorhynchus keta) Skin Using Sprague-Dawley Rat

A Chronic Oral Toxicity Study of Marine Collagen Peptides Preparation from Chum Salmon (Oncorhynchus keta) Skin Using Sprague-Dawley Rat

Enzymatic Determination of Diglyceride Using an Iridium Nano-Particle Based Single Use, Disposable Biosensor

Toxicological analysis of the chronic consumption of diheptanoin and triheptanoin in rats

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