A 16-Week Randomized Clinical Trial of 2000 International Units Daily Vitamin D<sub>3</sub>Supplementation in Black Youth: 25-Hydroxyvitamin D, Adiposity, and Arterial Stiffness

Dong, Yanbin; Stallmann‐Jorgensen, Inger; Pollock, Norman K.; Harris, Ryan A.; Keeton, Daniel; Huang, Ying; Li, Ké; Bassali, Reda; Guo, De Huang; Thomas, Jeffrey; Pierce, Gary L.; White, Jennifer; Holick, Michael F.; Zhu, Haidong

doi:10.1210/jc.2010-0606

Cited by 229 publications

(256 citation statements)

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“…A recent study on 24 black adolescents reported a significant decrease of aortic PWV during a 16-week vitamin D supplementation. 25 The crucial question is whether subjects with relatively mild hypovitaminosis, such as in our series, may have any benefit from vitamin D supplementation in terms of cardiovascular risk. A meta-analysis of 18 randomized controlled trials with vitamin D supplementation for osteoporosis in general population showed a significant 7% decrease in all-cause mortality, which is probably a higher benefit than can be expected from simple reduction of osteoporotic fractures.…”

Section: Discussionmentioning

confidence: 86%

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The association between low 25-hydroxyvitamin D and increased aortic stiffness

et al. 2011

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There is accumulating evidence that vitamin D exerts important pathophysiological effects on cardiovascular system. Low vitamin D was associated with increased cardiovascular risk in several reports. We studied the association between vitamin D and arterial stiffness in a random sample of 560 subjects selected from general population. Arterial stiffness was measured as aortic pulse-wave velocity (PWV) using Sphygmocor device. Serum 25-hydroxyvitamin D (25(OH)D) was measured using commercial kits. We found a clear negative trend in aortic PWV among 25(OH)D quartiles. Subjects in the bottom 25(OH)D quartile (o20 ng ml À1 ) showed the highest aortic PWV (9.04 m s À1 ), compared with 2nd-4th quartile (8.07 m s À1 , 7.93 m s À1 and 7.70 m s À1 , respectively; P for trend o0.0001). The association between 25(OH)D and aortic PWV remained significant after adjustment for age, gender and other potential confounders; subjects in the first 25(OH)D quartile had adjusted odds ratio 2.04 (1.26-3.30) for having aortic PWV X9 m s À1 (top quartile) in multiple regression. In conclusion, we found a clear significant and independent negative association between 25(OH)D and aortic PWV. Subjects with lowest vitamin D status showed the highest arterial stiffness.

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Section: Discussionmentioning

confidence: 86%

“…12 Venous blood samples were drawn in fasting state, and frozen serum samples stored at -80 degrees were used for biochemical laboratory analyses in the series. 25 …”

Section: Examinations and Materialsmentioning

confidence: 99%

The association between low 25-hydroxyvitamin D and increased aortic stiffness

et al. 2011

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“…On average, supplementation with high-doses of vitamin D (2000 IU) in healthy children has resulted in increments of serum 25OHD concentrations ranging from 37 to 52 nmol/L [146,167].…”

Section: Sample Sizementioning

confidence: 99%

“…[34,145,146]. It is important to note that the relationship between vitamin D intake and serum 25OHD concentrations is highly dependent on height and weight of individuals [146].…”

Section: Strengths and Limitationsmentioning

confidence: 99%

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Effect of high-dose vitamin D supplementation on bone density in youth with osteogenesis imperfecta: A randomized controlled trial

Plante

Veilleux

Glorieux

et al. 2016

Bone

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Background Osteogenesis imperfecta (OI) is a genetic disease characterized by fragile bones and short stature. Recently, a positive association was found between serum 25‐hydroxyvitamin D (25OHD) concentrations and lumbar spine areal bone mineral density (LS‐aBMD) z‐scores in this population. Objectives: To assess whether high‐dose vitamin D supplementation (2000 IU) will result in significantly higher LS‐aBMD z‐scores after one‐year; and to evaluate the effect of vitamin D supplementation on lower limb muscle power. Results: At baseline, average serum 25OHD concentration was 65.6 nmol/L (SD 20.4) with no difference seen between treatment groups (p=0.77). Deficient serum 25OHD concentrations (<50 nmol/L) were measured in only 21% of patients at baseline. Supplementation resulted in higher serum 25OHD concentrations in almost all participants (90%) with significantly higher increases seen with 2000 IU (mean [95% C.I.] = 30.5 nmol/L [21.3; 39.6] vs 15.2 nmol/L [6.4; 24.1], p= 0.02). No significant changes were detected in BMD measurements or in lower limb muscle power between treatment groups from baseline to final visit. Conclusions Supplementation with either 400 or 2000 IU of vitamin D translates into significant increases in serum 25OHD concentrations in children with OI. However, increases in baseline serum 25OHD concentrations already within a healthy range (蠅50 nmol/L) do not translate into increases in BMD z‐scores in children with OI. This research was supported by the Shriners Hospital for Children as well as by The Network for Oral and Bone Health Research.

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Inverse associations between cardiometabolic risk factors and 25‐hydroxyvitamin D in obese American children and adolescents

Lee

Ebert

Kadakia

et al. 2016

American J Hum Biol

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A 16-Week Randomized Clinical Trial of 2000 International Units Daily Vitamin D₃Supplementation in Black Youth: 25-Hydroxyvitamin D, Adiposity, and Arterial Stiffness

Abstract: Daily 2000 IU vitamin D supplementation may be effective in optimizing vitamin D status and counteracting the progression of aortic stiffness in black youth. Plasma 25(OH)D concentrations in response to the 2000 IU/d supplementation are negatively modulated by adiposity.

Cited by 229 publications

References 40 publications

The association between low 25-hydroxyvitamin D and increased aortic stiffness

The association between low 25-hydroxyvitamin D and increased aortic stiffness

Effect of high-dose vitamin D supplementation on bone density in youth with osteogenesis imperfecta: A randomized controlled trial

Inverse associations between cardiometabolic risk factors and 25‐hydroxyvitamin D in obese American children and adolescents

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A 16-Week Randomized Clinical Trial of 2000 International Units Daily Vitamin D3Supplementation in Black Youth: 25-Hydroxyvitamin D, Adiposity, and Arterial Stiffness

Abstract: Daily 2000 IU vitamin D supplementation may be effective in optimizing vitamin D status and counteracting the progression of aortic stiffness in black youth. Plasma 25(OH)D concentrations in response to the 2000 IU/d supplementation are negatively modulated by adiposity.

Cited by 229 publications

References 40 publications

The association between low 25-hydroxyvitamin D and increased aortic stiffness

The association between low 25-hydroxyvitamin D and increased aortic stiffness

Effect of high-dose vitamin D supplementation on bone density in youth with osteogenesis imperfecta: A randomized controlled trial

Inverse associations between cardiometabolic risk factors and 25‐hydroxyvitamin D in obese American children and adolescents

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Product

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A 16-Week Randomized Clinical Trial of 2000 International Units Daily Vitamin D₃Supplementation in Black Youth: 25-Hydroxyvitamin D, Adiposity, and Arterial Stiffness