A 16-microcantilever array sensing system for the rapid and simultaneous detection of analyte

Alodhayb, Abdullah; Rahman, Shofiur; Georghiou, Paris E.; Beaulieu, Luc

doi:10.1016/j.snb.2016.06.049

Cited by 14 publications

(8 citation statements)

References 30 publications

(63 reference statements)

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“…Both designs can be used for a variety of physical, chemical, and biological sensing applications, [351][352][353] and arrays of microcantilevers have been proposed to increase both measurement speed and selectivity. 354 In contrast to inorganic porous materials such as zeolites, MOFs are particularly attractive as analyte recognition layers for static microcantilevers, as they can exhibit large changes in crystal lattice parameters upon guest adsorption, resulting in detectable mechanical strain. This concept was first exploited to detect water vapor using HKUST-1 thin films on a silicon microcantilever with a built-in piezoresistive sensor.…”

Section: Chemical Sensorsmentioning

confidence: 99%

An updated roadmap for the integration of metal–organic frameworks with electronic devices and chemical sensors

et al. 2017

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Metal-organic frameworks (MOFs) are typically highlighted for their potential application in gas storage, separations and catalysis. In contrast, the unique prospects these porous and crystalline materials offer for application in electronic devices, although actively developed, are often underexposed. This review highlights the research aimed at the implementation of MOFs as an integral part of solid-state microelectronics. Manufacturing these devices will critically depend on the compatibility of MOFs with existing fabrication protocols and predominant standards. Therefore, it is important to focus in parallel on a fundamental understanding of the distinguishing properties of MOFs and eliminating fabrication-related obstacles for integration. The latter implies a shift from the microcrystalline powder synthesis in chemistry labs, towards film deposition and processing in a cleanroom environment. Both the fundamental and applied aspects of this two-pronged approach are discussed. Critical directions for future research are proposed in an updated high-level roadmap to stimulate the next steps towards MOF-based microelectronics within the community.

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Section: Chemical Sensorsmentioning

confidence: 99%

An updated roadmap for the integration of metal–organic frameworks with electronic devices and chemical sensors

et al. 2017

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“…Mechanical biosensors are generally more complex to fabricate and model, as they require a transducer of some kind, whereas electrical biosensors produce their own signal. Mechanical biosensors are more widespread, QCM and SAW based biosensors [ 237 ] in particular are important commercial scientific tools; but photoacoustics [ 238 ] and microcantilevers [ 239 ] are also becoming more common, whereas in electrical systems only ECIS has a significant commercial market [ 240 ]. Electrical biosensors are more likely to provide general information about an analyte (polarisability, impedance etc.)…”

Section: Resultsmentioning

confidence: 99%

Biosensors Based on Mechanical and Electrical Detection Techniques

Chalklen

Jing

Kar‐Narayan

2020

Sensors

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Biosensors are powerful analytical tools for biology and biomedicine, with applications ranging from drug discovery to medical diagnostics, food safety, and agricultural and environmental monitoring. Typically, biological recognition receptors, such as enzymes, antibodies, and nucleic acids, are immobilized on a surface, and used to interact with one or more specific analytes to produce a physical or chemical change, which can be captured and converted to an optical or electrical signal by a transducer. However, many existing biosensing methods rely on chemical, electrochemical and optical methods of identification and detection of specific targets, and are often: complex, expensive, time consuming, suffer from a lack of portability, or may require centralised testing by qualified personnel. Given the general dependence of most optical and electrochemical techniques on labelling molecules, this review will instead focus on mechanical and electrical detection techniques that can provide information on a broad range of species without the requirement of labelling. These techniques are often able to provide data in real time, with good temporal sensitivity. This review will cover the advances in the development of mechanical and electrical biosensors, highlighting the challenges and opportunities therein.

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“…The cantilevers and fixed-fixed beams were specifically fabricated to be used as the pheromone mass sensor in a label free manner and in real time. These microdevices have received much attention among the researchers during the last few years for sensing of biomolecules353637383940414243444546. The other advantages of these MEMS devices, that they are inexpensive and are readily available, have higher mass sensitivity and faster response time, make them ideal for large scale deployment.…”

Section: Resultsmentioning

confidence: 99%

A novel bio-engineering approach to generate an eminent surface-functionalized template for selective detection of female sex pheromone of Helicoverpa armigera

Moitra

Bhagat

Pratap

et al. 2016

Sci Rep

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Plant pests exert serious effects on food production due to which the global crop yields are reduced by ~20–40 percent per year. Hence to meet the world’s food needs, loses of food due to crop pests must be reduced. Herein the silicon dioxide based MEMS devices are covalently functionalized for robust and efficient optical sensing of the female sex pheromones of the pests like Helicoverpa armigera for the first time in literature. The functionalized devices are also capable of selectively measuring the concentration of this pheromone at femtogram level which is much below the concentration of pheromone at the time of pest infestation in an agricultural field. Experiments are also performed in a confined region in the presence of male and female pests and tomato plants which directly mimics the real environmental conditions. Again the reversible use and absolutely trouble free transportation of these pheromone nanosensors heightens their potentials for commercial use. Overall, a novel and unique approach for the selective and reversible sensing of female sex pheromones of certain hazardous pests is reported herein which may be efficiently and economically carried forward from the research laboratory to the agricultural field.

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A 16-microcantilever array sensing system for the rapid and simultaneous detection of analyte

Cited by 14 publications

References 30 publications

An updated roadmap for the integration of metal–organic frameworks with electronic devices and chemical sensors

An updated roadmap for the integration of metal–organic frameworks with electronic devices and chemical sensors

Biosensors Based on Mechanical and Electrical Detection Techniques

A novel bio-engineering approach to generate an eminent surface-functionalized template for selective detection of female sex pheromone of Helicoverpa armigera

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