A 13-week repeated-dose oral toxicity and bioaccumulation of aluminum oxide nanoparticles in mice

Park, Eun-Jung; Sim, Jaehoon; Kim, Younghun; Han, Beom Seok; Yoon, Cheol Yong; Lee, Somin; Cho, Myung‐Haing; Lee, Byoung‐Seok; Kim, Jae-Ho

doi:10.1007/s00204-014-1256-0

Cited by 52 publications

(38 citation statements)

References 38 publications

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“…In addition, long-AlNRs generally induced stronger toxicity than short-AlNRs. considering that orally administered-AlNPs primarily accumulated in liver and kidney (Park et al 2014) and lung is the main exposure route of nanoparticles, we suggest that target organ of AlNRs may be kidney and lung.…”

Section: Il-1βmentioning

confidence: 86%

“…Additionally, the unique properties of nanoparticles interfere with the performance of toxicity tests, especially in vitro (Kroll et al 2012;Monteiro-Riviere et al 2009). In our previous study, rod type of AlNPs (1.5, 3, and 6 mg/kg) accumulated in liver, kidney, heart, lung, and thymus after repeated oral dosing for 13 weeks (Park et al 2014a(Park et al , 2014b, and sphere type of AlNPs (15, 30, and 60 mg/ kg) accumulated in the brain, thymus, and lung after 4 weeks administration orally (Park et al 2011). Herein, we aimed comparing toxicity of aluminum oxide nanorods (AlNRs), which have different aspect ratio in vivo and in vitro.…”

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confidence: 97%

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Comparison of the toxicity of aluminum oxide nanorods with different aspect ratio

et al. 2014

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Aluminum oxide nanoparticles are listed among 14 high-priority nanomaterials published by the Organization for Economic Co-operation and Development, but limited information is available on their potential hazards. In this study, we compared the toxicity of two different aluminum oxide nanorods (AlNRs) commercially available in vivo and in vitro. Considering aspect ratio, one was 6.2 ± 0.6 (long-AlNRs) and the other was 2.1 ± 0.4 (short-AlNRs). In mice, long-AlNRs induced longer and stronger inflammatory responses than short-AlNRs, and the degree reached the maximum on day 7 for both types and decreased with time. In addition, in vitro tests were performed on six cell lines derived from potential target organs for AlNPs, HEK-293 (kidney), HACAT (skin), Chang (liver), BEAS-2B (lung), T98G (brain), and H9C2 (heart), using MTT assay, ATP assay, LDH release, and xCELLigence system. Long-AlNRs generally produced stronger toxicity than short-AlNRs, and HEK-293 cells were the most sensitive for both AlNRs, followed by BEAS-2B cells, although results from 4 kinds of toxicity tests conflicted among the cell lines. Based on these results, we suggest that toxicity of AlNRs may be related to aspect ratio (and resultant surface area). Furthermore, novel in vitro toxicity testing methods are needed to resolve questionable results caused by the unique properties of nanoparticles.

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Section: Il-1βmentioning

confidence: 86%

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confidence: 97%

Comparison of the toxicity of aluminum oxide nanorods with different aspect ratio

et al. 2014

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“…Cytokines and chemokines are extracellular proteins that initiate the migration of immune cells to the damaged sites. The levels of IL‐6, MCP‐1 and GM‐CSF, have been shown to increase in a dose‐dependent manner in the animals treated with NPs (Park et al, ). Otherwise, the eosinopenia was found in the animals treated with NPs, implying acute inflammation and oxidative stress (Park et al, ).…”

Section: The Impacts Of Nps On Major Target Organsmentioning

confidence: 99%

“…The levels of IL‐6, MCP‐1 and GM‐CSF, have been shown to increase in a dose‐dependent manner in the animals treated with NPs (Park et al, ). Otherwise, the eosinopenia was found in the animals treated with NPs, implying acute inflammation and oxidative stress (Park et al, ). Furthermore, red pulp inflammation, white pulp atrophy, and thinnest capsules were observed in the spleens of guinea pigs dermally exposed to silver NPs for 4 to 5 h (Korani et al, ).…”

Section: The Impacts Of Nps On Major Target Organsmentioning

confidence: 99%

Review of the effects of manufactured nanoparticles on mammalian target organs

Wu¹,

Tang

2017

J of Applied Toxicology

178

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Nanotechnology had matured significantly during the last two decades as it has transitioned from bench top science to applied technology. Even though the issue of safety of nanotechnology has been raised nearly one decade ago, the rapid progress in development and use of nanomaterials has not yet been matched by toxicological investigations. Many recent studies have simply outlined the toxic effects of nanoparticles (NPs), but few have systematically addressed their potentially adverse biological effects on target organs. Some animal models have shown that NPs could be accumulated in various organs. These accumulations can access the vasculature and target other organs, resulting in a potential health risks. After the brief description of current knowledge on the wide applications of several common NPs, their applications and the toxicokinetics, this review focused on effects of NPs on organ functions and mammal health after acute or chronic exposure, and potential mechanisms of action. Due to their physical properties, the liver, kidneys and lung are the main target organs of NPs. Most of NPs show slight toxicity when exposed to animals, while certain toxic effects like oxidative stress generation, inflammation and DNA damage are commonly observed. The severity of NPs toxicity is dependent upon several factors, including exposure dose and administration, NPs chemistry, size, shape, agglomeration state, and electromagnetic properties, which could provide useful information necessary to control the toxicity of NPs. Finally, the safety evaluation of nanotoxicity was addressed.

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“…The samples were incubated at 37°C for 2 h and then centrifuged at 8000 g for 20 min. After centrifugation, the residual Al level in the supernatant was analyzed by inductively coupled plasma mass spectrometry (ICP-MS, NexIon-300X; PerkinElmer) [19]. The background Al concentration was measured by preparing living and dead pellets in ultrapure water instead of Al solution.…”

Section: Methodsmentioning

confidence: 99%

The therapeutic protection of a living and dead Lactobacillus strain against aluminum-induced brain and liver injuries in C57BL/6 mice

Tian

Zhai

et al. 2017

PLoS ONE

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Our previous study found that Lactobacillus plantarum CCFM639 had the ability to alleviate acute aluminum (Al) toxicity when the strain was introduced simultaneously with Al exposure. This research was designed to elucidate the therapeutic effects of living and dead L. plantarum CCFM639 against chronic Al toxicity and to gain insight into the protection modes of this strain. Animals were assigned into control, Al only, Al + living CCFM639, and Al + dead CCFM639 groups. The Al exposure model was established by drinking water for the first 4 weeks. The strain was given after Al exposure by oral gavage at 109 colony-forming units once per day for 12 weeks. The results show that the Al binding ability of dead CCFM639 was similar to that of living CCFM639 in vitro. The ingestion of living or dead CCFM639 has similar effects on levels of Al and trace element in tissues, but living strains led to more significant amelioration of oxidative stress and improvement of memory deficits in Al-exposed mice. In conclusion, in addition to intestinal Al sequestration, CCFM639 treatment offers direct protection against chronic Al toxicity by alleviation of oxidative stress. Therefore, L. plantarum CCFM639 has a potential as dietary supplement ingredient that provides protection against Al-induced injury.

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A 13-week repeated-dose oral toxicity and bioaccumulation of aluminum oxide nanoparticles in mice

Cited by 52 publications

References 38 publications

Comparison of the toxicity of aluminum oxide nanorods with different aspect ratio

Comparison of the toxicity of aluminum oxide nanorods with different aspect ratio

Review of the effects of manufactured nanoparticles on mammalian target organs

The therapeutic protection of a living and dead Lactobacillus strain against aluminum-induced brain and liver injuries in C57BL/6 mice

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