A 12 year follow up study in the general population on prognostic factors of cartilage loss in osteoarthritis of the knee.

Schouten, Jan S. A. G.; Ouweland, F. A. Van Den; Valkenburg, H. A.

doi:10.1136/ard.51.8.932

Cited by 266 publications

(189 citation statements)

References 22 publications

(6 reference statements)

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“…The clinical diagnosis of local OA made by a physical examination was not related to radiologic progression of knee OA in the study by Schouten et al (37).…”

Section: Resultsmentioning

confidence: 82%

“…No significant association was found between current use, past use, or never use of estrogen and progression of knee OA. Schouten et al (37) found no association between uric acid concentration and progression of knee OA.…”

Section: Resultsmentioning

confidence: 97%

“…Schouten et al (37) found a significant association between age and progression of knee OA only for the comparison of the fourth quartile (higher age) versus the first quartile (lower age). In their Bruyere ( BMD ϭ bone mass density; IGF-1 ϭ insulin-like growth factor 1.…”

Section: Resultsmentioning

confidence: 98%

“…For insulin-like growth factor 1 (IGF-1), Schouten et al (37) found a significant association between progression of knee OA in the third versus the first tertile only. No significant association was found for the second versus the first tertile.…”

Section: Resultsmentioning

confidence: 99%

“…In the study by Cooper et al (29), the relationship between previous knee injury and progression of OA was investigated. In the study by Schouten et al (37), knee injury was assessed at followup. Schouten et al (37) also investigated the relationship between sport injury and progression of OA, but no statistically significant association was found.…”

Section: Resultsmentioning

confidence: 99%

See 4 more Smart Citations

Prognostic factors of progression of osteoarthritis of the knee: A systematic review of observational studies

Belo¹,

Berger²,

Reijman³

et al. 2007

Arthritis & Rheumatism

165

132

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Objective. To provide an overview of prognostic factors of knee osteoarthritis (OA) progression. Methods. We searched Medline and Embase up to December 2003 according to a specified search strategy (keywords for disease, location, and study design). Studies that fulfilled predefined criteria were assessed for methodologic quality. Study characteristics and associations were extracted and the results were summarized according to a best evidence synthesis. Results. Of the 1,004 studies found, 37 met the inclusion criteria. Methodologic quality was assessed and only highquality studies were included (n ‫؍‬ 36). The best evidence synthesis yielded strong evidence that hyaluronic acid serum levels and generalized OA are predictive for progression of knee OA. Sex, knee pain, radiologic severity, knee injury, quadriceps strength, and regular sport activities were not predictive. Conflicting evidence for associations was found for several factors including body mass index and age. Limited evidence for an association with progression of knee OA was found for several factors, including the alignment (varus/valgus) of the joint. Limited evidence for no association with progression of OA was also found for several factors, including meniscectomy, several markers of bone or cartilage turnover, and the clinical diagnosis of localized OA. Conclusion. Generalized OA and level of hyaluronic acid seem to be associated with the radiologic progression of knee OA. Knee pain, radiologic severity at baseline, sex, quadriceps strength, knee injury, and regular sport activities seem not to be related. For other factors, the evidence was limited or conflicting.

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“…The clinical diagnosis of local OA made by a physical examination was not related to radiologic progression of knee OA in the study by Schouten et al (37).…”

Section: Resultsmentioning

confidence: 82%

Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Prognostic factors of progression of osteoarthritis of the knee: A systematic review of observational studies

Belo¹,

Berger²,

Reijman³

et al. 2007

Arthritis & Rheumatism

165

132

View full text Add to dashboard Cite

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Natural History of Knee Cartilage Defects and Factors Affecting Change

Ding¹,

Cicuttini²,

Scott³

et al. 2006

Arch Intern Med

150

162

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Background: Knee cartilage defects may play an important role in early osteoarthritis, but little is known about their natural history.Methods: Knee cartilage defect score (range, 0-4), cartilage volume, and bone surface area were determined using T1-weighted fat-saturated magnetic resonance imaging in 325 subjects (mean age, 45 years) at baseline and 2 years later.Results: Thirty-three percent of the subjects had a worsening (Ն1-point increase) and 37% of the subjects had an improvement (Ն1-point decrease) in cartilage defect score in any knee compartment during 2.3 years. A worsening in cartilage defect score was significantly associated with female sex (odds ratio [OR], 3.09 and 3.64 in the medial and lateral tibiofemoral compartments) and baseline factors, including age (OR, 1.05 per year in the medial tibiofemoral compartment), body mass index (OR, 1.08 in the lateral tibiofemoral compartment), tibiofemoral osteophytes (OR, 6.22 and 6.04 per grade), tibial bone area (OR, 1.24 and 2.07 per square centimeter), and cartilage volume (OR, 2.91 and 1.71 per milliliter in the medial tibiofemoral and patellar compartments). An improvement in cartilage defect score had similar but reversed associations with these factors (except for sex), including a decrease in body mass index (OR, 1.23 in the medial tibiofemoral compartment).Conclusions: Knee cartilage defects are variable, and changes are associated with female sex, age, and body mass index. Increases are associated with baseline cartilage volume, bone size, and osteophytes, suggesting a role for these in the pathogenesis of cartilage defects. Interventions such as weight loss may improve knee cartilage defects.

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The Role of Knee Alignment in Disease Progression and Functional Decline in Knee Osteoarthritis

Sharma

Song²,

Felson

et al. 2001

JAMA

1,271

948

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A 12 year follow up study in the general population on prognostic factors of cartilage loss in osteoarthritis of the knee.

Abstract: The natural history and prognostic factors of cartilage loss in osteoarthritis of the knee were studied in subjects from a general population survey on rheumatic diseases in

Cited by 266 publications

References 22 publications

Prognostic factors of progression of osteoarthritis of the knee: A systematic review of observational studies

Prognostic factors of progression of osteoarthritis of the knee: A systematic review of observational studies

Natural History of Knee Cartilage Defects and Factors Affecting Change

The Role of Knee Alignment in Disease Progression and Functional Decline in Knee Osteoarthritis

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