A 12‐Week Physical and Cognitive Exercise Program Can Improve Cognitive Function and Neural Efficiency in Community‐Dwelling Older Adults: A Randomized Controlled Trial

Nishiguchi, Shu; Yamada, Minoru; Tanigawa, Tetsuya; Sekiyama, Kaoru; Kawagoe, Toshikazu; Suzuki, Maki; Yoshikawa, Sakiko; Abe, Nobuhito; Otsuka, Yuki; Nakai, Ryusuke; Aoyama, Tomoki; Tsuboyama, Tadao

doi:10.1111/jgs.13481

Cited by 154 publications

(190 citation statements)

References 43 publications

(60 reference statements)

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“…In contrast, diminished connectivity may represent greater efficiency as the networks can effectively allocate resources to areas of immediate importance. Certainly, emerging evidence suggests that lifestyle interventions can improve neural efficiency (Smith et al, 2013; Nishiguchi et al, 2015). …”

Section: Discussionmentioning

confidence: 99%

The Impact of Aerobic Exercise on Fronto-Parietal Network Connectivity and Its Relation to Mobility: An Exploratory Analysis of a 6-Month Randomized Controlled Trial

Hsu

Best

Wang

et al. 2017

Front. Hum. Neurosci.

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Impaired mobility is a major concern for older adults and has significant consequences. While the widely accepted belief is that improved physical function underlies the effectiveness of targeted exercise training in improving mobility and reducing falls, recent evidence suggests cognitive and neural benefits gained through exercise may also play an important role in promoting mobility. However, the underlying neural mechanisms of this relationship are currently unclear. Thus, we hypothesize that 6 months of progressive aerobic exercise training would alter frontoparietal network (FPN) connectivity during a motor task among older adults with mild subcortical ischemic vascular cognitive impairment (SIVCI)—and exercise-induced changes in FPN connectivity would correlate with changes in mobility. We focused on the FPN as it is involved in top-down attentional control as well as motor planning and motor execution. Participants were randomized either to usual-care (CON), which included monthly educational materials about VCI and healthy diet; or thrice-weekly aerobic training (AT), which was walking outdoors with progressive intensity. Functional magnetic resonance imaging was acquired at baseline and trial completion, where the participants were instructed to perform bilateral finger tapping task. At trial completion, compared with AT, CON showed significantly increased FPN connectivity strength during right finger tapping (p < 0.05). Across the participants, reduced FPN connectivity was associated with greater cardiovascular capacity (p = 0.05). In the AT group, reduced FPN connectivity was significantly associated with improved mobility performance, as measured by the Timed-Up-and-Go test (r = 0.67, p = 0.02). These results suggest progressive AT may improve mobility in older adults with SIVCI via maintaining intra-network connectivity of the FPN.

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Section: Discussionmentioning

confidence: 99%

The Impact of Aerobic Exercise on Fronto-Parietal Network Connectivity and Its Relation to Mobility: An Exploratory Analysis of a 6-Month Randomized Controlled Trial

Hsu

Best

Wang

et al. 2017

Front. Hum. Neurosci.

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“…Thus, it seems very speculative to describe such mechanism only after 9.5 weeks of IATP‐R. Moreover, positive effects of AT on cognitive function and cerebral oxygenation during cortical activation have been reported in the literature . We, therefore, suggest that the IATP‐R experienced the most profound structural and functional neural adaptations which enabled training group to better perform cognitive tests better compared to controls.…”

Section: Discussionmentioning

confidence: 83%

Effects of a short-term Interval Aerobic Training Programme with active Recovery bouts (IATP-R) on cognitive and mental health, functional performance and quality of life: A randomised controlled trial in sedentary seniors

et al. 2018

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“…Regarding the effects of the education program on health behavior, average number of steps per day, physical activity level, and dietary variety increased significantly. Based on existing physical activity intervention research findings, in which typical behavioral change techniques (feedback, goal‐setting) were provided, participants took 7% to 54% more steps per day . In the present study, intervention group participants actively learned the importance of healthy lifestyle, and planned behavioral change independently planned behavioral change.…”

Section: Discussionmentioning

confidence: 92%

Effects of Active Learning on Health Literacy and Behavior in Older Adults: A Randomized Controlled Trial

Uemura

Yamada

Okamoto

2018

J American Geriatrics Society

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A 12‐Week Physical and Cognitive Exercise Program Can Improve Cognitive Function and Neural Efficiency in Community‐Dwelling Older Adults: A Randomized Controlled Trial

Abstract: A 12-week physical and cognitive exercise program can improve the efficiency of brain activation during cognitive tasks in older adults, which is associated with improvements in memory and executive function.

Cited by 154 publications

References 43 publications

The Impact of Aerobic Exercise on Fronto-Parietal Network Connectivity and Its Relation to Mobility: An Exploratory Analysis of a 6-Month Randomized Controlled Trial

The Impact of Aerobic Exercise on Fronto-Parietal Network Connectivity and Its Relation to Mobility: An Exploratory Analysis of a 6-Month Randomized Controlled Trial

Effects of a short-term Interval Aerobic Training Programme with active Recovery bouts (IATP-R) on cognitive and mental health, functional performance and quality of life: A randomised controlled trial in sedentary seniors

Effects of Active Learning on Health Literacy and Behavior in Older Adults: A Randomized Controlled Trial

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