A 12 country field study of the EORTC QLQ-C30 (version 3.0) and the head and neck cancer specific module (EORTC QLQ-H&amp;N35) in head and neck patients

Bjordal, Kristin; Graeff, Alexander de; Fayers, Peter; Hammerlid, Eva; Pottelsberghe, C van; Curran, Desmond; Ahlner-Elmqvist, Marianne; Maher, E.J.; Meyza, J; Brédart, Anne; Söderholm, Anna-Liisa; Arrarás, J.I.; Feine, Jocelyne S.; Abendstein, Helmut; Morton, Randall P.; Pignon, T.; Pu, Huguenin; Bottomly, A; Kaasa, Stein

doi:10.1016/s0959-8049(00)00186-6

Cited by 700 publications

(592 citation statements)

References 29 publications

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“…The fact that FACT-H&N considers these items answer optional, may encourage patients to not answer such questions and justify these results, which are consistent with other studies reporting a large proportion of missing data when considering the Sexuality item [38,39]. Asymmetry and flatness measures do not differentiate the questionnaires although EORTC QLQ-C30 flattening measure revealed to be closer to a normal distribution.…”

Section: Discussionsupporting

confidence: 82%

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Patient reported outcomes in head and neck cancer: selecting instruments for quality of life integration in clinical protocols

et al. 2010

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BackgroundHealth Related Quality of Life has been used in medical research for more than twenty years, being progressively accepted during the last decade as an important patient reported outcome. Considering the multidimensional approach involved in Health Related Quality of Life assessment, instrument applicability and cultural adaptation must be tested for each population. In order to select the most appropriate instrument for Head and Neck cancer patients, two major Health Related Quality of Life specific questionnaires for Head and Neck cancer patients were compared. Conceptual differences, psychometric characteristics, scores, reliability, construct validity and sensitivity to symptomatology, tumour location, tumour size were analyzed.Methods102 consecutive Head and Neck cancer patients completed two different Health Related Quality of Life questionnaires: EORTC QLQ-C30 and its specific head and neck module QLQ-H&N35 and the Functional Assessment of Cancer Therapy Scales (FACT-H&N). Patients completed the questionnaires, immediately before consultation as a part of the routine evaluation.ResultsA greater variability was always found in the EORTC QLC-C30 questionnaire's scores for all comparable domains. Both instruments revealed a good internal consistency and demonstrated to be good tools to distinguish symptomatic patients. The EORTC questionnaires still demonstrated sensitivity to distinguish T3 and T4 staging. Conceptual differences and the psychometric characteristics are discussed. Our results suggest that these two instruments assess different aspects of Health Related Quality of Life - the questionnaires should be used separately and chosen according to the study objectives and methodology.ConclusionsThis study emphases the importance in selecting the appropriate tool as a critical success factor in implementing routine Health Related Quality of Life assessment in clinical practice. This decision assumes particularly importance when utilization of results in real time and integration into clinical protocols are considered.

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Section: Discussionsupporting

confidence: 82%

“…The easy, acceptable and understandable questionnaires format may facilitate its potential inclusion in routine clinical protocols [38-40]. …”

Section: Discussionmentioning

confidence: 99%

Patient reported outcomes in head and neck cancer: selecting instruments for quality of life integration in clinical protocols

et al. 2010

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“…[22,23,27,34,40,42,51,69], using at least one of the following standardized quality-of-life questionnaires: the University of Washington Quality of life questionnaire (UWQol) [85], the Functional Assessment of Cancer Therapy-General (FACT-G) [86], the Functional Assessment of Cancer Therapy-Head and Neck questionnaire (FACT-HN) [86,87], the Quality of Life Questionnaire C-30 (QLQ-C30) [88][89][90], the Quality of Life Questionnaire-Head and Neck 35 (QLQ-HN35) [30,91,92], the European Organisation for Research and Treatment of Cancer (EORTC/RTOG) [85,93,94], and the Performance Status Scale for Head and Neck Cancer Patients (PSS-HN) [95,96]. Most of the studies reported signiWcant improvement for most questionnaire scales over time.…”

Section: Crt and Quality Of Lifementioning

confidence: 99%

Functional outcomes and rehabilitation strategies in patients treated with chemoradiotherapy for advanced head and neck cancer: a systematic review

Molen

Rossum

Burkhead

et al. 2008

Eur Arch Otorhinolaryngol

109

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Organ preservation with radiotherapy and concomitant chemotherapy has become an accepted treatment modality in advanced head and neck cancer. Unfortunately, organ preservation is not synonymous with function preservation. The aim of this review was to systematically assess the eVects of the disease and chemoradiotherapy (CRT) on functions such as swallowing, mouth opening, nutrition, pain and quality of life in patients with head and neck cancer. Another aim was to search for (evidence-based) techniques or strategies known to alleviate or rehabilitate the loss of function(s) associated with CRT. Two databases were searched (time period, January 1997 to August 2007) for the terms head and neck cancer, chemotherapy or cisplatin and radiotherapy, and the functional outcomes swallowing, trismus, nutrition, pain and quality of life or a variation of those words. In total, 15 relevant articles were identiWed that met the inclusion criteria. The majority of the studies that met the criteria focused on the outcomes swallowing, quality of life, and nutrition. Two studies reported on the outcome pain, but no paper reported on the outcome trismus. Only two papers mentioned rehabilitation options, but speciWc information was lacking. Further long-term prospective research is essential, not only to determine the function impairment caused by the tumor and CRT, but also to assess the eVects of known and newly developed rehabilitation measures. Therefore, in September 2006, the Netherlands Cancer Institute started a randomised clinical trial (RCT): Prevention of trismus, swallowing and speech problems in patients treated with chemoradiotherapy for advanced head and neck cancer. This systematic review was carried out to collect the baseline information for the future outcomes of this RCT.

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“…9,10 These modules are developed through four phases according to guidelines established by the QLG. [9][10][11] Modules related to cancer in the breast (BR23), 12 head and neck (H&N35), 13,14 and lung (LC13) 15 have so far been validated in large-scale international field studies. 8 A number of modules are under development in Phases III and IV (oesophageal, ovarian, bladder, brain, colorectal, gastric, pancreatic and prostate cancer, multiple myeloma, and satisfaction with care).…”

Section: Introductionmentioning

confidence: 99%

The EORTC Ophthalmic Oncology Quality of Life Questionnaire Module (EORTC QLQ-OPT30). Development and Pre-Testing (Phase I-III)

Brandberg

Damato

Kivelä

et al. 2004

Eye

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Aims The research objective was to develop a questionnaire module to be used, in addition to the European Organisation into Research and Treatment of Cancer (EORTC) QLQ-C30, for measurement of quality of life (QL) among patients with uveal melanoma treated with methods such as transpupillary thermotherapy, plaque radiotherapy, proton beam radiotherapy, local resection, and enucleation. The present paper describes the development through Phases I-III. Methods Relevant QL issues were generated from literature search and from interviews with ophthalmologists, nurses, and patients with uveal melanoma representing three major treatment options: enucleation, plaque brachytherapy, and proton beam therapy. Results The provisional module was pretested in 61 patients from Finland, Sweden, and UK. The EORTC QLQ-OPT30 module consists of 26 items for all patients, and four additional items for patients receiving treatments other than enucleation. It measures ocular irritation, vision impairment, headache, worry about recurrent disease, problems with driving, problems with appearance functional problems due to vision impairment, and problems reading. Conclusions Several treatment modalities are available for uveal melanoma. There is limited knowledge of the impact of these treatments on QL in the long and short term. We hope that the OPT30 module together with the EORTC QLQ-C30 core questionnaire can be a useful tool in research.

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A 12 country field study of the EORTC QLQ-C30 (version 3.0) and the head and neck cancer specific module (EORTC QLQ-H&N35) in head and neck patients

Cited by 700 publications

References 29 publications

Patient reported outcomes in head and neck cancer: selecting instruments for quality of life integration in clinical protocols

Patient reported outcomes in head and neck cancer: selecting instruments for quality of life integration in clinical protocols

Functional outcomes and rehabilitation strategies in patients treated with chemoradiotherapy for advanced head and neck cancer: a systematic review

The EORTC Ophthalmic Oncology Quality of Life Questionnaire Module (EORTC QLQ-OPT30). Development and Pre-Testing (Phase I-III)

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