A-1012G Promoter Polymorphism of Vitamin D Receptor Gene Is Associated with Psoriasis Risk and Lower Allele-Specific Expression

Richetta, Antonio Giovanni; Silvestri, Valentina; Giancristoforo, Simona; Rizzolo, Piera; D'Epiro, S; Graziano, V.; Mattozzi, Carlo; Navazio, Anna Sara; Campoli, Marco; D’Amico, Cristina; Scarnò, Marco; Calvieri, Stefano; Ottini, Laura

doi:10.1089/dna.2013.2217

Cited by 39 publications

(36 citation statements)

References 39 publications

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“…Several studies have identified an association between VDR polymorphisms and psoriasis susceptibility. [49][50][51] We have analyzed the polymorphisms of VDR gene and psoriasis susceptibility and we have found that in our population the A-1012G promoter polymorphism of the VDR gene is associated with psoriasis risk and the mRNA of VDR in this polymorphism is lower expressed, favoring the conditions that may alter cutaneous barrier and the development of psoriatic lesions. 51 Our group has studied the immunohistochemical expression of VDR, claudin-1, occludin and Zonulin-1 (ZO-1), demonstrating that psoriatic skin has a decreased expression of VDR and tight-junction proteins and that there is a correlation between the expression of VDR, claudin-1 and ZO-1, demonstrating that probably this micronutrient may preserve the cutaneous integrity ( Fig.…”

Section: Barrier Organsmentioning

confidence: 84%

“…Several studies have identified an association between VDR polymorphisms and psoriasis susceptibility . We have analyzed the polymorphisms of VDR gene and psoriasis susceptibility and we have found that in our population the A‐1012G promoter polymorphism of the VDR gene is associated with psoriasis risk and the mRNA of VDR in this polymorphism is lower expressed, favoring the conditions that may alter cutaneous barrier and the development of psoriatic lesions …”

Section: Barrier Organsmentioning

confidence: 99%

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Psoriasis, vitamin D and the importance of the cutaneous barrier's integrity: An update

Mattozzi¹,

Paolino²,

Richetta³

et al. 2016

The Journal of Dermatology

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Psoriasis is a common, inflammatory, chronic, relapsing skin disease. Despite several hypotheses having been postulated to explain the pathogenesis of this disorder, nowadays it is considered as a T-cell-mediated disease; in this context an important role is played by vitamin D. The role of this micronutrient is important for many reasons: it is able to modulate the immune system; it is implicated in keratinocyte turnover; and it is involved in the integrity of the cutaneous barrier. In psoriasis, this molecule plays an important role due to its ability in the modulation of innate and adaptive immunity and by its antiproliferative and pro-differentiative effects on keratinocytes. Alteration of the metabolism of vitamin D may alter the cutaneous barrier integrity and favor an infective and inflammatory condition. The importance of vitamin D in the pathogenesis of psoriasis is not a mere mental exercise but may open further perspectives in the treatment of this disorder just preventing alterations of immune homeostasis, modulating the proliferation of keratinocyte, regulating the microbial flora and the response of the host to infective diseases.

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Section: Barrier Organsmentioning

confidence: 84%

Section: Barrier Organsmentioning

confidence: 99%

Psoriasis, vitamin D and the importance of the cutaneous barrier's integrity: An update

Mattozzi¹,

Paolino²,

Richetta³

et al. 2016

The Journal of Dermatology

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“…Richetta et al [89] showed that among 5 common VDR polymorphisms (A-1012G, FokI, BsmI, ApaI, and TaqI), the A-1021G polymorphism is associated with the risk of psoriasis in an Italian population. In another study, ApaI and a specific haplotype of 5 VDR polymorphisms were associated with the risk of psoriasis in a Chinese population [90].…”

Section: Role Of Vitamin D In Certain Inflammatory Skin Diseasesmentioning

confidence: 99%

Vitamin D and the Pathophysiology of Inflammatory Skin Diseases

Umar

Sastry

Ali

et al. 2018

Skin Pharmacol Physiol

141

135

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Background: Vitamin D is a secosteroid, which was initially known for its skeletal role; however, in recent years, its functions in different organs have been increasingly recognized. In this review, we will provide an overview of vitamin D functions in the skin physiology with specific focus on its role in certain inflammatory skin conditions such as psoriasis and atopic dermatitis. Methods: A comprehensive literature search was carried out in PubMed and Google Scholar databases using keywords like “vitamin D,” “skin,” “atopic dermatitis,” and “psoriasis.” Only articles published in English and related to the study topic were included in this review. Results: Vitamin D is integrally connected to the skin for its synthesis, metabolism, and activity. It regulates many physiological processes in the skin ranging from cellular proliferation, differentiation, and apoptosis to barrier maintenance and immune functions. Vitamin D deficiency is associated with the risk of psoriasis and atopic dermatitis, and several clinical/observational studies have suggested the beneficial effect of vitamin D in the therapy of these 2 inflammatory skin disorders. Conclusions: Vitamin D exerts a pleiotropic effect in the skin and could be an important therapeutic option for psoriasis and atopic dermatitis.

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“…Several studies identified an association between polymorphisms of vitamin D receptor ( VDR ) and psoriasis susceptibility [9]. Richetta et al, have found that the A-1012G promoter polymorphism of the VDR gene is associated with psoriasis risk through a lower expression of VDR mRNA, favoring conditions that may alter cutaneous barrier and the development of psoriatic lesions [31]. In addition, in psoriatic skin a decreased expression of VDR and reduced tight-junction proteins is associated [32].…”

Section: The Dermatologist’s Point Of Viewmentioning

confidence: 99%

Vitamin D and its role in psoriasis: An overview of the dermatologist and nutritionist

Barrea

Savanelli

Somma

et al. 2017

Rev Endocr Metab Disord

193

188

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Psoriasis is a chronic immune-mediated inflammatory skin disease. Psoriasis lesions are characterized by hyper-proliferation of epidermal keratinocytes associated with inflammatory cellular infiltrate in both dermis and epidermis. The epidermis is the natural source of vitamin D synthesis by sunlight action. Recently, a role for vitamin D in the pathogenesis of different skin diseases, including psoriasis, has been reported. Indeed, significant associations between low vitamin D status and psoriasis have been systematically observed. Due to its role in proliferation and maturation of keratinocytes, vitamin D has become an important local therapeutic option in the treatment of psoriasis. To date, the successful treatment based on adequate dietary intake of vitamin D or oral vitamin D supplementation in psoriasis represent an unmet clinical need and the evidence of its beneficial effects remains still controversial. This information is important either for Dermatologists and Nutritionists to increases the knowledge on the possible bi-directional relationships between low vitamin D status and psoriasis and on the potential usefulness of vitamin D in psoriasis with the aim not only to reduce its clinical severity, but also for delineating the risk profile for co-morbidities cardiac risk factors that may result from psoriasis. In the current review, we analyzed the possible bi-directional links between psoriatic disease and vitamin D.

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A-1012G Promoter Polymorphism of Vitamin D Receptor Gene Is Associated with Psoriasis Risk and Lower Allele-Specific Expression

Cited by 39 publications

References 39 publications

Psoriasis, vitamin D and the importance of the cutaneous barrier's integrity: An update

Psoriasis, vitamin D and the importance of the cutaneous barrier's integrity: An update

Vitamin D and the Pathophysiology of Inflammatory Skin Diseases

Vitamin D and its role in psoriasis: An overview of the dermatologist and nutritionist

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