A 10-year retrospective study of alterative aeroallergens sensitization spectrum in urban children with allergic rhinitis

Abstract

ObjectiveTo investigate the alterative spectrum and trends of aeroallergens sensitization in children with allergic rhinitis (AR) in Guangzhou, China in the past 10 years.Participants and methodsIn this retrospective study, 4,111 children with complaints of nasal hyper-reactivity who visited the Pediatric Department and/or Otolaryngology Department from January 2007 to November 2016 were enrolled. Serum specific immunoglobulin E was measured and positive detection was made in 3,328 patients, who were, therefore, diagnosed with AR. Positive rates and trends of different aeroallergens sensitization were assessed. The tendency of positive rates changing over the years, and the difference and trends in positive rate of aeroallergen sensitization that occurred in subgroups of gender, age, and season were determined and analyzed with logistic regression.ResultsThe percentage of detected common aeroallergens in AR children was (from high to low) 81.07%, 34.44%, 14.72%, 11.81%, 6.04%, and 3.70% for house dust mites (HDMs), cat–dog dander, cockroach, mold mixture, tree pollen mixture, and herb pollen mixture, respectively. An ascending trend of aeroallergens sensitization or AR (odds ratio [OR] =1.116, 95% CI: 1.086–1.146) was found. Interestingly, an increasing trend of cat–dog dander and mold sensitization was found in AR children (OR =1.164, 95% CI: 1.133–1.196; OR =1.169, 95% CI: 1.120–1.223) in this retrospective study, while HDMs sensitization held a steady trend (OR =0.983, 95% CI: 0.961–1.007).ConclusionIn the increasing trend of aeroallergens sensitization or AR, HDMs sensitization still held the majority. But emphasis should be made on pet allergy for young children with AR in the context of ascending trend of sensitization to cat–dog dander.

Assessing the effect of meteorological factors on daily children’s respiratory disease hospitalizations: a retrospective study

“…The biological mechanism of the relationship between relatively mild environments and children's respiratory diseases may be related to the effect of allergen (e.g., mites and pollen) growth. The Asian dust storm was also associated with hospital admissions for respiratory diseases [21,22]. These meteorological factors usually appear in spring and autumn in Baotou.…”

Pollen-related food allergy in children with seasonal allergic rhinitis

“…Tree pollen was the most frequent sensitizing allergens in both groups. In other population studies, grass was one of the main pollen allergens being the cause of SAR in children the cause of SAR [ 9 , 10 ], but it should be remembered that the spectrum of sensitizing allergens depends on the patient’s age and place of residence [ 11 – 13 ].…”

Assessing the effects of meteorological factors on daily children's respiratory disease hospitalizations: A retrospective study

“…The biological mechanism of the relationship between relatively mild environments and children's respiratory diseases might be related to the effect of allergen (e.g., mites and pollen) growth. Asian dust storms were also associated with hospital admissions for respiratory diseases [ 23 , 24 ]. These meteorological factors usually appear in spring and autumn in Baotou; compared with winter, the temperature is warmer, the humidity is lower, and the wind speed is higher at these times of the year.…”