A 0.09 $\text{mm}^2$ On-Chip Wireless Power Transfer System Designed in 0.5 $\mu$m CMOS Process for Brain Neuromodulation Applications

Biswas, Dipon K.; Mahbub, Ifana

doi:10.1109/jerm.2020.2985568

Cited by 5 publications

(1 citation statement)

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“…Voltage pulses with at least a few volts are required for most stimulation protocols. To meet these requirements, the implant may contain a passive rectifier [ 22 ], a microcontroller [ 17 ], or CMOS integrated circuitry [ 23 ], [ 24 ]. Within the past few decades, current-controlled neurostimulator designs have become favored over constant-voltage designs, in order to reduce stimulation variance caused by electrode impedance changes.…”

Section: Introductionmentioning

confidence: 99%

Wireless Stimulation of Motor Cortex Through a Collagen Dura Substitute Using an Ultra-Thin Implant Fabricated on Parylene/PDMS

Benbuk,

Gulick,

Moniz-Garcia

et al. 2024

IEEE Trans. Biomed. Circuits Syst.

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We present the design, fabrication, and in vivo testing of an ultra-thin (100 μ m) wireless and battery-free implant for stimulation of the brain’s cortex. The implant is fabricated on a flexible and transparent parylene/PDMS substrate, and it is miniaturized to dimensions of 15.6 × 6.6 mm 2 . The frequency and pulse width of the monophasic voltage pulses are determined through On-Off keying (OOK) modulation of a wireless transmission at 2.45 GHz. Furthermore, the implant triggered a motor response in vivo when tested in 6 rodents. Limb response was observed by wireless stimulation of the brain’s motor cortex through an FDA-approved collagen dura substitute that was placed on the dura in the craniotomy site, with no direct contact between the implant’s electrodes and the brain’s cortical surface. Therefore, the wireless stimulation method reported herein enables the concept of an e-dura substitute, where wireless electronics can be integrated onto a conventional dura substitute to augment its therapeutic function and administer any desired stimulation protocol without the need for post-surgical intervention for battery replacement or reprogramming stimulation parameters.

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