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Kimura, Shigeyoshi; Yoshino, Atsuo; Katayama, Yoichi; Watanabe, Takao; Fukushima, Takao

doi:10.1023/a:1019919019497

Cited by 31 publications

(12 citation statements)

References 48 publications

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“…IL12 found to be down-regulated in our study is an inhibitor of angiogenesis and display anti-tumorigenic function [ 66 ]. βNGF was found to inhibit growth of rat C6 glioma cells [ 67 ].…”

Section: Discussionmentioning

confidence: 99%

An Eighteen Serum Cytokine Signature for Discriminating Glioma from Normal Healthy Individuals

et al. 2015

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Glioblastomas (GBM) are largely incurable as they diffusely infiltrate adjacent brain tissues and are difficult to diagnose at early stages. Biomarkers derived from serum, which can be obtained by minimally invasive procedures, may help in early diagnosis, prognosis and treatment monitoring. To develop a serum cytokine signature, we profiled 48 cytokines in sera derived from normal healthy individuals (n = 26) and different grades of glioma patients (n = 194). We divided the normal and grade IV glioma/GBM serum samples randomly into equal sized training and test sets. In the training set, the Prediction Analysis for Microarrays (PAM) identified a panel of 18 cytokines that could discriminate GBM sera from normal sera with maximum accuracy (95.40%) and minimum error (4.60%). The 18-cytokine signature obtained in the training set discriminated GBM sera from normal sera in the test set as well (accuracy 96.55%; error 3.45%). Interestingly, the 18-cytokine signature also differentiated grade II/Diffuse Astrocytoma (DA) and grade III/Anaplastic Astrocytoma (AA) sera from normal sera very efficiently (DA vs. normal–accuracy 96.00%, error 4.00%; AA vs. normal–accuracy 95.83%, error 4.17%). Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis using 18 cytokines resulted in the enrichment of two pathways, cytokine-cytokine receptor interaction and JAK-STAT pathways with high significance. Thus our study identified an 18-cytokine signature for distinguishing glioma sera from normal healthy individual sera and also demonstrated the importance of their differential abundance in glioma biology.

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“…IL12 found to be down-regulated in our study is an inhibitor of angiogenesis and display anti-tumorigenic function [ 66 ]. βNGF was found to inhibit growth of rat C6 glioma cells [ 67 ].…”

Section: Discussionmentioning

confidence: 99%

An Eighteen Serum Cytokine Signature for Discriminating Glioma from Normal Healthy Individuals

et al. 2015

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“…We suppose that biochemical immunological and physical effects are responsible for growth inhibition of glioma tumor. A few mechanisms are suggested in some reports, including the following (Figure 2): Differentiation and growth inhibition of glioma cells in vitro, which may be due to the production of NGF by the MSCs 48,65,75

A cytotoxic mechanism that involves the differentiation of rat MSCs into immune effector cells 68,69

…”

Section: Discussionmentioning

confidence: 99%

“…Differentiation and growth inhibition of glioma cells in vitro, which may be due to the production of NGF by the MSCs 48,65,75…”

Section: Discussionmentioning

confidence: 99%

The role of stem cells in tumor targeting and growth suppression of gliomas

Eskandary¹,

Basiri²,

Nematollahi-Mahani³

et al. 2011

BTT

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Glioma remains the most challenging solid organ tumor to treat successfully. Based on the capacity of stem cells to migrate extensively and target invading glioma cells, the transplantation of stem cells as a cell-based delivery system may provide additional tools for the treatment of gliomas. In addition to the use of modified stem cells for the delivery of therapeutic agents, unmodified stem cells have been shown to have growth-suppressing effects on tumors in vitro and in vivo. This review outlines the probable factors involved in tumor tropism and tumor growth suppression, with a specific focus on the use of unmodified stem cells in the treatment of gliomas. Based on these and further future data, clinical trials may be justified.

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“…Either in tranplacental or postnatal ENU-exposure, NGF treatment caused a reduction of the number of ENU-induced neuromas in rats [ 52 , 53 ]. As observed after topical administration, exogenous NGF can arrest tumor cell proliferation in human ocular glioma, prompting to the hypothesis of an inhibitory rather than promoting NGF effect on cancer cell (stimulation and tumor progression) [ 46 , 54 , 55 ]. These observations seem to support the hypothesis that the predominant expression of trkA NGFR might facilitate cell differentiation while the p75 NTR expression in the absence of trkA NGFR might facilitate cell proliferation [ 56 ].…”

Section: Introductionmentioning

confidence: 99%

Nerve growth factor: role in growth, differentiation and controlling cancer cell development

Aloe

Rocco

Balzamino

et al. 2016

J Exp Clin Cancer Res

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Recent progress in the Nerve Growth Factor (NGF) research has shown that this factor acts not only outside its classical domain of the peripheral and central nervous system, but also on non-neuronal and cancer cells. This latter observation has led to divergent hypothesis about the role of NGF, its specific distribution pattern within the tissues and its implication in induction as well as progression of carcinogenesis. Moreover, other recent studies have shown that NGF has direct clinical relevance in certain human brain neuron degeneration and a number of human ocular disorders. These studies, by suggesting that NGF is involved in a plethora of physiological function in health and disease, warrant further investigation regarding the true role of NGF in carcinogenesis. Based on our long-lasting experience in the physiopathology of NGF, we aimed to review previous and recent in vivo and in vitro NGF studies on tumor cell induction, progression and arrest. Overall, these studies indicate that the only presence of NGF is unable to generate cell carcinogenesis, both in normal neuronal and non-neuronal cells/tissues. However, it cannot be excluded the possibility that the co-expression of NGF and pro-carcinogenic molecules might open to different consequence. Whether NGF plays a direct or an indirect role in cell proliferation during carcinogenesis remains to demonstrate.

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Cited by 31 publications

References 48 publications

An Eighteen Serum Cytokine Signature for Discriminating Glioma from Normal Healthy Individuals

An Eighteen Serum Cytokine Signature for Discriminating Glioma from Normal Healthy Individuals

The role of stem cells in tumor targeting and growth suppression of gliomas

Nerve growth factor: role in growth, differentiation and controlling cancer cell development

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