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Synthesis and mutagenic activity of the hydrochlorides of S-(2-alkoxy-5-acetylbenzyl)isothioureas and 3-substituted aminomethyl-4-alkoxyacetophenones

“…2-Alkoxy-5-acetylbenzylchlorides were prepared by the action of formalin or paraform and hydrogen chloride on 4-alkoxyacetophenones at 40 -45°C as described in [1]. Yields and physicochemical constants were consistent with published values [4,5].…”

“…Previous studies used 2-alkoxy-5-acetylbenzylchlorides in the synthesis of substituted benzylpyrimidines, oximes, and hydrazones, which are of interest in relation to their antitumor, mutagenic, and antibacterial activities [1,2].…”

Michael Cyclization of Polarized Systems: Synthesis and in vitro Anti-Diabetic Evaluation of Some Novel Pyrimidine, Pyridine, Pyrazole and Pyrazolo[3,4-b ]pyridine Derivatives

“…Pyrimidines, as the most important nitrogen-containing heterocyclic compounds, are of chemical and pharmacological interest. Many studies have been shown that compounds containing the pyrimidine ring possess antidiabetic, antibacterial, antifungal, antimalarial, and anticonvulsant activities, [12][13][14][15][16] and anticancer activities, [17,18] and many of pyrimidine compounds were reported to act as calcium channel blockers, [19] and as potential central nervous system (CNS) depressants. [20,21] Also, Pyrazoline derivatives widely occur in the environment, in the form of alkaloids, vitamins and pigments as constituents of plant and animal cell.…”

Synthesis and Antimicrobial Activity of Some Novel Chalcones of 3-Acetyl Pyridine and their Pyrimidine Derivatives

“…In the present communication we report the reaction of 3-acetylpyridine with different aromatic aldehydes (2 a-g ) to form chalcones [1][2][3][4][5][6][7][8][9][10][11][12][13] (3 a-g ) in the presence of alkali. The resulting chalcones after purification and characterization by physical and spectral methods have been successfully converted into substituted pyrimidines [14][15][16][17][18][19] (4 a-g ) by reaction with guanidine hydrochloride. The structures of the various synthesized compounds were assigned on the basis of elemental analyses, IR, 1 H NMR, 13 C NMR and mass spectral data.…”