Synthesis and Antimicrobial Activity of Some Novel Chalcones of 3-Acetyl Pyridine and their Pyrimidine Derivatives

Abstract

Chalcones afford a facile route of access to many of the heterocyclic systems containing oxygen and nitrogen. An attempt is therefore made to synthesize chalcones from 3-acetylpyridine by reaction with either aromatic or heteroaromatic aldehyde using Claisen-Schmidt condensation. The resulting chalcones after purification and characterization by physical and spectral methods have been successfully converted into substituted pyrimidines by reaction with guanidine hydrochloride. All these compounds were characterized by means of their IR, 1 H NMR, 13 C NMR and mass spectral data. These compounds were evaluated for antimicrobial activities by cup plate method.

Semi-Synthetic Pyrazoline Derivatives from Polygonum senegalense Chalcones and their Anti-Microbial Activities

“…They have been reported to possess antioxidant, antimicrobial, anti-leishmanial, anti-inflammatory, anti-tumour and antibacterial activity. 3 The presence of a reactive, unsaturated keto moietyin chalcones is found to be responsible for their antimicrobial activity, which may be altered depending on the type and position of substituent on the rings. 3 Hence, they have become desired targets for semi-synthesis of new compounds with improved pharmacological profiles.…”

“…3 The presence of a reactive, unsaturated keto moietyin chalcones is found to be responsible for their antimicrobial activity, which may be altered depending on the type and position of substituent on the rings. 3 Hence, they have become desired targets for semi-synthesis of new compounds with improved pharmacological profiles. 3 Most current anti-microbial agents are chemically semi-synthetic modifications of various natural compounds.…”

“…3 Hence, they have become desired targets for semi-synthesis of new compounds with improved pharmacological profiles. 3 Most current anti-microbial agents are chemically semi-synthetic modifications of various natural compounds. 4 More importantly, this class of compounds has been extensively employed in the synthesis of heterocyclic systems.…”

“…4 More importantly, this class of compounds has been extensively employed in the synthesis of heterocyclic systems. 3 Heterocyclic compounds possess a wide range of biological activities. Much attention is on the synthesis of heterocycles bearing nitrogen and oxygen containing ring systems mainly due to their higher pharmacological activity.…”

Design, synthesis, and evaluation of novel 2-phenylpropionic acid derivatives as dual COX inhibitory-antibacterial agents

“…Therefore, a dual COX inhibitory-antibacterial agent with an improved safety profile is necessary for enhanced therapeutic benefits and better patient compliance. Prompted from this requirement lot of studies have been reported [28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43] . As a result, above-mentioned information directed us to synthesize some novel 2-(4-substitutedmethylphenyl)propionic acid derivatives and investigate their inhibitory activity against COX-1, COX-2 enzymes and various microbial strains.…”