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Abstract

In order to develop biomaterials for hard bone repair, biomimetic scaffolds were prepared from a mixture of hydroxyapatite (HA), β-tricalcium phosphate (TCP), and calcium silicate (CS) at optimal weight ratios via the sintering technique. Composites obtained had homogeneous pore distribution and open pore morphology. Depending on the amount of CS added and the sintered temperature, the porosity obtained varied in a range of 47-64%. The scaffolds flexural strength and modulus of the scaffolds were comparable to that of cancellous bone. Improved mechanical properties were achieved by introducing CS at elevated sintering temperature. Fine particles of CS are more resistant to heat than those of HA or TCP, which are larger in diameter. Integration of CS grains with the HA/TCP composite does not occur by sintering at 1250°C. CS particles were mainly distributed at the composite grain boundaries, and played a role in cracking resistance. To test bioactivity in vitro, the scaffolds were immersed in phosphate buffered saline for 3 weeks, and then assessed for apatite forming ability. Apatite did not form on the scaffolds sintered at 1050 and 1150°C, but it did in those sintered at 1250°C. The new biomaterials produced are suitable to prepare scaffolds, which may be used for long bone tissue engineering.

Comparison between the Astaxanthin Release Profile of Mesoporous Bioactive Glass Nanoparticles (MBGNs) and Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV)/MBGN Composite Microspheres

“…The zeta potential of MBGN/ASX nanoparticles and composite microspheres is shown in Figure 1c. The values showed moderate stability, which may reduce the probability of undesired agglomeration for in vivo and in vitro applications [43,44]. Similar Zeta potential values have been observed in previous formulations using MBGN-and PHBV-based particles [21,45,46].…”

Reduction of the in vitro toxicity of elevated concentrations of SPIONLA by its administration through PHBV/curcumin composite microspheres

“…The Zeta potential of composite microspheres is shown in Figure 2C. The values measured in this aqueous environment are moderately stable, suggesting that composite microspheres will not agglomerate quickly in vivo and in vitro applications, at least in conditions with similar pH, aquosity, and ion concentration (Hill et al, 1977;Kaewsichan et al, 2011). Besides, it is possible that microspheres, due to their size, tend to precipitate in static conditions and after a specific time.…”

Evaluation of Structural Stability, Mechanical Properties, and Corrosion Resistance of Magnesia Partially Stabilized Zirconia (Mg-PSZ)

“…To examine the stability in a biological setting, Mg-PSZ was soaked in a simulated body fluid, followed by measurement of pH in the solution and changes in specimen weight, according to previous study [ 48 ]. Briefly, prepared Mg-PSZ block was soaked in a simulated body fluid which has very similar ionic composition to human blood plasma.…”