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doi:10.13040/ijpsr.0975-8232.3(3).659-81

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…To investigate insulin delivery from the buccal mucosa, the distribution of fluorescence probe in the epithelium using confocal laser scanning microscopy and fluorescence probe isothiocyanate-labeled insulin penetration were examined. The results demonstrated that the fluorescent probe isothiocyanate-labeled insulin can pass through the buccal mucosa, and that insulin passes through the epithelium, which includes both intracellular and paracellular pathways 40 . The world's first approved transbuccal release system for testosterone replacement therapy in men is a monoconvex, tablet-like mucoadhesive buccal system, with a recommended dose of 30 mg at a 12-hour interval.…”

Section: Buccal Dosage Formsmentioning

confidence: 95%

Buccal Drug Delivery System: An Overview About Dosage Forms and Recent Studies

Güneş

Karavana

Yapar³

2020

Univ J Pharm Res

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Management of illness through medication is entering a new era in which growing number of novel drug delivery systems are being employed and are available for therapeutic use. Pharmaceutical research and development is currently focused on the development of drug delivery systems to target a drug to the desired organ or site with the aim of minimizing its overall distribution in the body. The oral mucosa has many properties which make it an attractive site for drug delivery but simultaneously provide several problems for researchers for effective and efficient delivery of therapeutic active agents. However, with the development of novel delivery techniques overcome several challenges. Oral mucosa delivery has many advantageslike high blood flow, rapid recovery, prevention of hepatic first-pass effect and pre-systemic elimation in gastrointestinal tract. On the other hand relatively small surface area and significant loss of drug due to swallowing and salivary flow are main limitations of buccal delivery. Different formulations including sprays, tablets, mouthwashes, gels, pastes and patches are presently used for delivery into and/or across the oral mucosa. Over the last 20 years, a wide range of formulations has been developed for buccal drug delivery systems but unfortunately few have been accomplished to be a medicine. One of the main reasons of this unsuccessful result could be the lack of the standardized methods which evaluate in vitro performance of buccal dosage forms. Thus aim of this review, to discuss the potential of buccal drug delivery and buccal dosage forms and also explore recent studies and in vitro analysesmethodology of buccal dosage forms. Peer Review History: UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file Average Peer review marks at initial stage: 4.5/10 Average Peer review marks at publication stage: 7.0/10 Name: Robert Tungadi Affiliation: State University of Gorontalo, Indonesia E-mail: rtungadi@yahoo.com Name: Dr. Sally A. El-Zahaby Affiliation: Pharos University in Alexandria, Egypt E-mail: sally.elzahaby@yahoo.com Comments of reviewer(s): Similar Articles: BUCCAL DRUG DELIVERY SYSTEM: A TOOL FOR THE EFFECTIVE DELIVERY OF PHARMACEUTICALS

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Section: Buccal Dosage Formsmentioning

confidence: 95%

Buccal Drug Delivery System: An Overview About Dosage Forms and Recent Studies

Güneş

Karavana

Yapar³

2020

Univ J Pharm Res

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Preparation and In Vitro/Ex Vivo Evaluation of Buccoadhesive Discs of an Anti-Parkinson Drug: Relationship between Mucoadhesivity, Drug Release and Permeability

Monajjemzadeh¹,

Bagheri²,

Montazam³

et al. 2018

Pharm Sci

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IntroductionSelegiline hydrochloride (Sel) is a drug utilized for the therapy of early-stage Parkinson's disease, depression, and dementia. In usual clinical doses, it is an elective invariable MAO-B inhibitor. Nasal and subcutaneous routes exert some limitations such as lower retention time for nasal solution and difficulty in self-administration for injectable ones. These forms have certain disadvantages. Film and disc of buccomucoadhesive drugs are of delivery profit, as the film solves and the oral drug is administered through absorption in the mouth (buccally or sublingually) and/or in small gut (intestinally). 1Hence the aims of present project were; to extend a novel drug delivery system for Sel which might be carried via the buccal route (discs created with microspheres), to exclusively target the mucous area in order to attain a quick relief by rapid beginning of operation; to enhance bioavailability; and to elude the secondary dose administration. The buccal discs can be better alternates that may decrease the side effects related to oral and parenteral remedies. In treating the Parkinson's, constant levels of the drug are required in the blood for an extended period. This can be settled by designing a buccal drug delivery system that could deliver the drug via oral buccal mucosa. The hydrophilic Sel may show low bioavailability when administered through the buccal route. And once in the systemic circulation, hydrophilicity is required for effective distribution. Therefore, the use of buccoadhesive Sel was proposed. However, in order to achieve the result, the modification of its absorption was A B S T R A C TBackground: Selegiline hydrochloride (Sel) is a drug applied for the therapy of early-step Parkinson's disease. In usual clinical doses, it is an elective irreversible MAO-B inhibitor. This study intended to formulate mucoadhesive microspheres of selegiline with the objective of improving the therapeutic efficacy, patient compliance and bioavailability. Methods: The microspheres were prepared by emulsion solvent evaporation method (O1/ O2) using hydroxypropyl methylcellulose (HPMC). In the current study, bucco-adhesive microspheres were prepared with different drug to polymer ratios and characterized by encapsulation efficiency, particle size, Differential Scanning Calorimetry (DSC), FTIR Fourier Transform Infrared Spectroscopy (FTIR), flowability, the degree of swelling and surface pH, mucoadhesive character, retentive time, and drug release studies. Results:The best drug to polymer ratio in microspheres was 1:2 (as F1). The production yield microspheres F1 showed production yield of 84.79%, mean particle size of 744.73 μm and loading efficiency of 53.33%. The DSC exhibited the property of selegiline loaded microspheres changed to amorphous form. The FTIR spectrum proposed that the drug kept its chemical stability during the emulsification process. The results showed that the microspheres of F1 had faster release than the microspheres of F2 (1:4), F3 (1:6), and commercial tablet (p<0.05). The mic...

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Cited by 2 publications

References 15 publications

Buccal Drug Delivery System: An Overview About Dosage Forms and Recent Studies

Buccal Drug Delivery System: An Overview About Dosage Forms and Recent Studies

Preparation and In Vitro/Ex Vivo Evaluation of Buccoadhesive Discs of an Anti-Parkinson Drug: Relationship between Mucoadhesivity, Drug Release and Permeability

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