Buccal Drug Delivery System: An Overview About Dosage Forms and Recent Studies

Mucoadhesive buccal films have gained significant attention as a promising drug delivery system for various therapeutic applications. This review article provides a comprehensive overview of the recent advancements in mucoadhesive buccal films, focusing on their formulation strategies, mucoadhesive mechanisms and potential applications. The article discusses the various polymers used in the formulation of mucoadhesive buccal films, including natural, synthetic, and semi-synthetic polymers. The selection of appropriate polymers plays a crucial role in achieving optimal mucoadhesive properties and drug release characteristics. Furthermore, the influence of different formulation factors, such as plasticizers, penetration enhancers, and drug loading techniques, on the performance of buccal films is thoroughly examined. The discussion covers a wide range of topics, beginning with the structure and physiology of the buccal mucosa, which elucidates the particular properties that impact medication absorption. The complete examination of mucoadhesive polymers, nanoparticles, and thin film technologies is included in the comprehensive overview of formulation techniques.INTRODUCTION: Among the different methods of administering drugs, transmucosal drug delivery provides significant benefits compared to oral administration for achieving systemic effects, and the buccal mucosa is highly suitable for delivering drugs locally and systemically.

Section: Fig 8: Solid Dispersion Techniques Formulation Aspects Of Mu...mentioning

confidence: 99%

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2024

“…This is why artificial sweeteners are increasingly used in both food and medicine. The first generation of artificial sweeteners includes saccharin, cyclamate and aspartame; the second generation includes acesulfame-K, sucralose, alitame and neotame 31 .…”

Section: Ideal Characteristics Of the Drug To Be Selectedmentioning

confidence: 99%

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2023

To increase patient compliance, safety, and effectiveness, the need for the design and development of a new dosage form has arisen. Novel film technology like buccal film meets all these needs. The buccal film is inserted into the mouth and the medicine is then absorbed via the buccal mucosa. Compared to alternative buccal drug delivery systems such as wafers, lozenges, microparticles, gel and tablets, buccal film is a more appealing and acceptable dosage form due to its small size, dose and ease of administration. Because it avoids first-pass digestion, buccal film is a very efficient dose form that significantly boosts bioavailability. It is more practical than other forms of dosing because it sticks well to the buccal mucosa of the mouth. Not ingesting the medicine is necessary; it is non-irritating and cost-efficient; other benefits include its sleek design, ease of use and biodegradability. Therefore, this dose type is preferred by both elderly and young patients. This review focuses on buccoadhesive drug delivery methods, which are reliant on adhering to mucuscoated biological surfaces. There is now a need for further investigation on topics like patient convenience and compliance. This article thoroughly analyzes buccal film, including its uses, drawbacks and advantages, methods of production, assessment criteria and formulation.

“…According to the findings, the barrier baking layer protected the nanoparticle reservoirs for precise drug delivery. Surprisingly, the scientists claimed that many kinds of nanoparticles, including virus-like particles, liposomes, lipid-based nanoparticles, and polymeric nanoparticles may be combined into nanofibrous materials for non-invasive mucosal treatments 22 . An electronspun layer was created and self-assembled into liposomes after coming into contact with water.…”

Section: Multilayer Films Containing Nanostructure Materialsmentioning

confidence: 99%

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2023

The development of mucoadhesive buccal formulations has recently gained a great deal of attention. Despite several proposed solutions, drug permeability and regulated drug release via this mode of delivery remain concerns for successful therapy. Clinical uses for recent advances in nanotechnology have been examined. In addition to ensuring effective distribution, the use of nanoparticles in dosage forms for buccal administration also helps to minimize any negative effects on biological systems. To load and distribute drug-containing nanoparticles to the buccal mucosa for topical and systemic applications, several strategies have been proposed. In order to improve medication delivery or targeting, this study outlines contemporary cutting-edge approaches for using nanoparticles in dosage forms. Of give a general overview of current approaches to implementing controlled drug delivery, these technologies are categorized and discussed. All of these noteworthy results will promote novel nanoparticle-delivered dose formulations for buccal distribution in clinical settings. Overall, the buccal mucosa provides a lot of advantages for controlled pharmaceutical delivery over an extended period of time. INTRODUCTION:Several different layers of cells are located at the buccal mucosa, including stratum filamentosum, stratum distendum, stratum basale, stratum suprabasale, submucosa, and lamina propria. Because the mucosa and smooth muscle are largely static, buccal drug administration is advantageous due to patient compliance, simplicity of administration and removal, minimal enzymatic activity, and appropriateness for controlled release dose forms 1 . Drugs delivered buccally can be used for both local and systemic treatment. This kind of local therapy can maintain medication delivery at the intended spot while reducing unwanted effects.