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Hanson, James R.

doi:10.1039/b103772m

Cited by 24 publications

(3 citation statements)

References 124 publications

(83 reference statements)

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“…Structural scrutiny of 1 suggested that it could be produced by incorporating two analogues of oxygenated eudesmanes. The structures of units A and B of compound 1 were similar to that of α-cyperone, which was well considered as a key precursor to synthesize the diversification of oxygenated eudesmanes . To search for biogenetically possible precursors of 1 , our attention was directed to isolate the compounds with molecular weights relating reasonably to α-cyperone.…”

Section: Resultsmentioning

confidence: 99%

Echingridimer A, an Oxaspiro Dimeric Sesquiterpenoid with a 6/6/5/6/6 Fused Ring System from Echinops grijsii and Aphicidal Activity Evaluation

Liu

Jiang

et al. 2019

J. Org. Chem.

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A new dimeric eudesmane sesquiterpenoid with an unreported 6/6/5/6/6 fused carbon skeleton, echingridimer A (1), and five monomers (2–6), including two new compounds (2 and 3), were isolated from the roots of Echinops grijsii. Their structures and absolute configurations were elucidated by comprehensive spectroscopic analyses and confirmed by X-ray crystallography or electronic circular dichroism spectra. Compound 1 represents the first example of a 3,15′-linked Michael-type adduct of two eudesmanes, which feature a unique 1-oxaspiro[4.5]decan moiety. The plausible biogenetic pathway for 1–6 was briefly discussed. The oxaspiro dimer (1) not only showed stronger aphicidal activity than closely related monomeric compounds (2–6) and the commercial aphicide pymetrozine but also exhibited remarkable insecticide activity against a broad range of aphids, thus could be used as a potential biobased insecticide to suppress aphids.

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Section: Resultsmentioning

confidence: 99%

Echingridimer A, an Oxaspiro Dimeric Sesquiterpenoid with a 6/6/5/6/6 Fused Ring System from Echinops grijsii and Aphicidal Activity Evaluation

Liu

Jiang

et al. 2019

J. Org. Chem.

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“…Phytocannabinoids are a group of terpenophenolic compounds, generally classified into 10 subclasses ( Hanuš et al, 2016 ). Among them, the most studied compounds are Δ 9 -THC and CBD.…”

Section: Phytochemistry Of Cannabis Terpenesmentioning

confidence: 99%

Analgesic Potential of Terpenes Derived fromCannabis sativa

et al. 2021

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Pain prevalence among adults in the United States has increased 25% over the past two decades, resulting in high health-care costs and impacts to patient quality of life. In the last 30 years, our understanding of pain circuits and (intra)cellular mechanisms has grown exponentially, but this understanding has not yet resulted in improved therapies. Options for pain management are limited. Many analgesics have poor efficacy and are accompanied by severe side effects such as addiction, resulting in a devastating opioid abuse and overdose epidemic. These problems have encouraged scientists to identify novel molecular targets and develop alternative pain therapeutics. Increasing preclinical and clinical evidence suggests that cannabis has several beneficial pharmacological activities, including pain relief. Cannabis sativa contains more than 500 chemical compounds, with two principle phytocannabinoids, Δ 9 -tetrahydrocannabinol (Δ 9 -THC) and cannabidiol (CBD). Beyond phytocannabinoids, more than 150 terpenes have been identified in different cannabis chemovars. Although the predominant cannabinoids, Δ 9 -THC and CBD, are thought to be the primary medicinal compounds, terpenes including the monoterpenes β -myrcene, α -pinene, limonene, and linalool, as well as the sesquiterpenes β -caryophyllene and α -humulene may contribute to many pharmacological properties of cannabis, including anti-inflammatory and antinociceptive effects. The aim of this review is to summarize our current knowledge about terpene compounds in cannabis and to analyze the available scientific evidence for a role of cannabis-derived terpenes in modern pain management. Significance Statement Decades of research have improved our knowledge of cannabis polypharmacy and contributing phytochemicals, including terpenes. Reform of the legal status for cannabis possession and increased availability (medicinal and recreational) have resulted in cannabis use to combat the increasing prevalence of pain and may help to address the opioid crisis. Better understanding of the pharmacological effects of cannabis and its active components, including terpenes, may assist in identifying new therapeutic approaches and optimizing the use of cannabis and/or terpenes as analgesic agents.

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“…Kunnumakkara et al showed Zyflamend in combination with gemcitabine synergically inhibited the growth of human pancreatic cells in vitro and in vivo by inhibiting NF- κ B signaling pathways [ 29 ]. MK615, called Ume in Japanese, is a sticky extract from Japanese apricot, which has been used to treat intestinal disorders for many years as an antipyretic and an anti-inflammatory agent [ 57 ]. Hattori et al indicated MK615, in both the presence and absence of gemcitabine, significantly inhibited the growth of human pancreatic cancer cells in vitro and in vivo without apparent adverse effects through a reactive oxygen species-dependent mechanism [ 30 ].…”

Section: Combination Of Natural Products With Gemcitabinementioning

confidence: 99%

Natural Products as Adjunctive Treatment for Pancreatic Cancer: Recent Trends and Advancements

Yue

Gao

Zou

et al. 2017

BioMed Research International

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Pancreatic cancer is a type of common malignant tumors with high occurrence in the world. Most patients presented in clinic had pancreatic cancer at advanced stages. Furthermore, chemotherapy or radiotherapy had very limited success in treating pancreatic cancer. Complementary and alternative medicines, such as natural products/herbal medicines, represent exciting adjunctive therapies. In this review, we summarize the recent advances of using natural products/herbal medicines, such as Chinese herbal medicine, in combination with conventional chemotherapeutic agents to treat pancreatic cancer in preclinical and clinical trials.

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Untitled

Cited by 24 publications

References 124 publications

Echingridimer A, an Oxaspiro Dimeric Sesquiterpenoid with a 6/6/5/6/6 Fused Ring System from Echinops grijsii and Aphicidal Activity Evaluation

Echingridimer A, an Oxaspiro Dimeric Sesquiterpenoid with a 6/6/5/6/6 Fused Ring System from Echinops grijsii and Aphicidal Activity Evaluation

Analgesic Potential of Terpenes Derived fromCannabis sativa

Natural Products as Adjunctive Treatment for Pancreatic Cancer: Recent Trends and Advancements

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