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Abstract

The in vivo enhancing-activity of Grz in the absorption of drugs is dependent on GA, a hydrolysis product of Grz resulting from the action of beta-glucuronidase in intestinal flora.

Electrophysiological Characterization of Tight Junctional Pathway of Rabbit Cornea Treated with Ophthalmic Ingredients

“…19,20,[22][23][24][25] It was reported that bile salt such as taurocholic acid enhanced permeability by removing epithelial cells, which constitute a major permeability barrier. 26,27) For bile salts, the rank order of the promoting effect was sodium deoxycholateϾsodium glycocholateϾsodium taurocholate.…”

Optimization of Suppository Preparation Containing Sodium Laurate and Taurine That Can Safely Improve Rectal Absorption of Rebamipide

“…As a technique of the improvement of solubility, micronization, amorphousization and the addition of surfactant such as Tween 80 and Captisol ® are well known. As for the improvement of permeability, the use of absorption enhancers is well known, [1][2][3][4][5][6][7][8][9][10][11] but the practical use of them has been very limited 12,13) because of the potential local toxicity to gastrointestinal mucosa. 2,4) In order to develop the safe formulation that can improve the absorption of drugs categorized into BCS Class IV such as rebamipide, [14][15][16][17][18][19][20] we have compared the suppository that contains sodium laurate (C12) as an absorption enhancer and taurine (Tau) as a cytoprotective adjuvant with the commercial suppository that contains sodium caprate (C10) as an absorption enhancer.…”

Liver Targeting Liposomes Containing .BETA.-Sitosterol Glucoside with Regard to Penetration-Enhancing Effect on HepG2 Cells.

“…We also reported that both SG and b-sitosterol glucoside (Sit-G), a major component of SG, are effective penetration enhancers of drugs across mucosal membranes and the enhancement effect of Sit-G is higher than that of SG. 9,10) Bile salt and glycyrrhizin are known to act as penetration enhancers in the intestinal, 11) nasal 12,13) and transdermal 14) absorption of drugs, and also as ligands for drug delivery to the liver by their specific affinities to hepatocytes. 15,16) Thus the penetration-enhancing effect of free SG or Sit-G on hepatocytes cannot be neglected, because they might be released by the degradation of SG-liposomes in the blood circulation or by Kupffer cells after i.v.…”