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Syntheses and some features of five new cyclohexane-1,3-dicarboxylates with multiple stereogenic centers

“…by condensation of acetylacetone or acetoacetic acid esters with aldehydes. These compounds are known for their important biological activities such as herbicidal, antibacterial, antifungal, convulsant, anticonvulsant, antiimplantation and antiasthmone, besides being useful in organic synthesis and in industry [5][6][7][8][9]. Thus, they are useful synthons in further synthetic endeavours, as they have multiple keto, hydroxy and ester functionalities, potentially available for further transformations.…”

“…As was mentioned, usually synthesis of the cyclohexanones of this type is carried out via one-pot MCRs, where several organic fragments are coupled in one step with a carbon-carbon formation and subsequent cyclization [5][6][7][8][10][11][12][13][14][15][16][17][18][19]. The methods of further modification of the thus prepared cyclohexanones with mono-or polyfunctional nucleophiles are also well studied [20][21][22][23][24][25][26][27][28].…”

Reactions of dimethyl and di-tert-butyl 2-aryl-4-hydroxy-4-methyl-6-oxocyclohexane-1,3-dicarboxylates with difunctional nucleophiles

“…The physical constants, spectral parameters, and procedures for preparation of compounds Ia3Ih were reported previously [6,7].…”