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Zaprianova, E; Делева, Денислава; Ilinov, P; Sultanov, Emil; Filchev, A.; Christova, L.; Sultanov, Borislav

doi:10.1023/a:1011027125744

Cited by 25 publications

(17 citation statements)

References 27 publications

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“…Эти данные полностью согласуются с нашими предыдущими исследованиями, которые показали значительное увеличение титра антител к GD1a и GM1 в сыворотке крови пациентов с рассеянным склерозом [5,7].…”

Section: Discussionunclassified

“…По данным наших предыдущих исследований [3,[5][6][7][8], высокие титры IgG анти-GD1a соответствуют нейродегенерации, в то время как высокие титры IgG анти-GM1 антител соответствуют наличию демиелинизации. Мы полагаем, что нейродегенерация может быть охарактеризована значениями титров антиганглиозидных антител к GD1a и GM1.…”

Section: Discussionunclassified

“…Основными ганглиозидами миелина ЦНС человека являются моносиалоганглиозиды GM1, а основную фракцию ганглиозидов тел нейронов составляет дисиалоганглиозид GD1a [4]. В норме показатели содержания ганглиозидов различных типов в плазме крови стабильны, но демонстрируют выраженные изменения при патологических состояниях [3]. В наших предыдущих исследованиях значительное увеличение содержания ганглиозида GD1a в сыворотке крови была отмечено у больных с рассеянным склерозом (РС) -нейродегенеративным многофакторным расстройством с аутоиммунным компонентом [5][6][7].…”

Section: Introductionunclassified

“…В норме показатели содержания ганглиозидов различных типов в плазме крови стабильны, но демонстрируют выраженные изменения при патологических состояниях [3]. В наших предыдущих исследованиях значительное увеличение содержания ганглиозида GD1a в сыворотке крови была отмечено у больных с рассеянным склерозом (РС) -нейродегенеративным многофакторным расстройством с аутоиммунным компонентом [5][6][7]. У больных с РС также были обнаружены аутоантитела против ганглиозидов GM1 и GD1a, причем высокий титр аутоантител против GM1 коррелировал с демиелинизацией, в то время как высокий титр аутоантител против GD1a был связан с нейродегенерацией [8], а именно с острой двигательной аксональной нейропатией и с острой моторно-сенсорной аксональной нейропатией [9].…”

Section: Introductionunclassified

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Serum igG antibodies to GD1a and GM1 gangliosides in elderly people

Kolyovska

2016

BIOMED KHIM

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Nowadays, the percentage of elderly people in society grows. Good nutrition and medical care help older people to have a normal life over 80 to 90 years. In the last ten years it is of critical importance to establish the clinical significance of serum IgG anti-GD1a and anti-GM1 ganglioside antibodies as potential biomarkers for neuronal damage in neurodegenerative diseases and immune-mediated neuropathies and demyelination. In the current study, the diagnostic values of IgG anti-GD1a and anti-GM1 antibodies were determined by the ELISA method in serum samples of 18 elderly patients (71-91 years). Significantly elevated serum IgG anti-GD1a and anti-GM1 antibodies titers were detected only in patients over 80 years. These data suggest that the immune-mediated neuropathies, neurodegeneration and demyelination in healthy elderly occur after 80 years old. Therefore, IgG anti-GD1a and anti-GM1 antibodies can serve as biomarkers, showing the nervous system dysfunction.

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Section: Discussionunclassified

Section: Introductionunclassified

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Serum igG antibodies to GD1a and GM1 gangliosides in elderly people

Kolyovska

2016

BIOMED KHIM

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“…Elevated levels of serum GGs have been measured in patients with colorectal cancer [7], and a specific GG class, disialoganglioside 2 (GD2), has been found in the serum of patients with neuroblastoma [8,9] and retinoblastoma [10]. Changes in the distribution of serum GGs have also been described during multiple sclerosis attacks [11]. Overall, the implication of GGs in oncogenesis [12], neurodevelopment and neurological diseases (Alzheimer [13], Tay-Sachs, Sandhoff [14], etc.)…”

Section: Introductionmentioning

confidence: 99%

Plasmatic Ganglioside Profile and Age-Related Macular Degeneration: A Case-Control Study

Dossarps¹,

Martine²,

Berdeaux³

et al. 2016

Ophthalmic Res

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Purpose: Gangliosides are glycosphingolipids that are particularly abundant in the nervous system, including the retina. However, their precise role in this tissue and its pathologies remain poorly understood. The objective of the present study was to characterize the ganglioside profile of human plasma and to determine whether it is affected in age-related macular degeneration (AMD). Methods: Eighty-three subjects were included: control subjects (n = 25), atrophic AMD patients (n = 27) and exudative AMD patients (n = 31). For each subject, gangliosides were extracted from plasma and analyzed by liquid chromatography coupled to mass spectrometry. Results: GM3 appeared to be by far the major ganglioside of human plasma, associated with GD3. No specific ganglioside class was detected in the plasma of AMD patients. Fourteen molecular species of GM3 and 9 species of GD3, accounting for the variability of the ceramide moiety of the ganglioside molecule, were identified and characterized. Analyses revealed no significant differences in the proportion of these species between control, atrophic and exudative AMD patient groups. Total GM3 levels did not differ either. Conclusion: Although gangliosides are considered important for the retina's structure and function, it seems that circulating gangliosides are not associated with the retinal damage occurring during the course of AMD.

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Reduced raft‐association of NF155 in active MS‐lesions is accompanied by the disruption of the paranodal junction

Maier

Baron

Hoekstra

2007

Glia

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Neurofascin155 (NF155) is required for the establishment of the paranodal axo-glial junction, the predominant interaction site between myelin and axon. It has been shown that the distribution of NF155 is altered in demyelinating diseases such as multiple sclerosis (MS). However, little is known about the biochemical mechanisms underlying these changes. We therefore compared NF155 in postmortem tissue of active and chronic inactive MS lesions with white matter from healthy controls. Although NF155 showed a very similar expression in all control white matter samples, a strong individual variation was observed in MS-lesions with NF155-levels reduced in most samples. At the same time an NF155-fragment was increased in MS-lesions, suggesting that NF155 is subject to protein degradation in lesion sites. Interestingly, the association of NF155 to membrane microdomains (rafts) was reduced in all lesions, irrespective of the amount of NF155, indicating that membrane association of NF155 was generally affected. Therefore, myelin fractionation experiments were performed to analyze the fate of paranodal proteins during demyelination. Although NF155 was enriched in heavy myelin from both control white matter and active MS-lesions, association of Caspr1/paranodin with heavy myelin was abolished in MS-lesions, demonstrating that paranodal junctions are disrupted. In conclusion, the data support the hypothesis that efficient raft-association of NF155 is essential for the assembly of the paranodal junction and demonstrate that reduced association of NF155 to lipid rafts is accompanied by the disassembly of the paranodal junction and thus contributes to the demyelination process in MS.

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Cited by 25 publications

References 27 publications

Serum igG antibodies to GD1a and GM1 gangliosides in elderly people

Serum igG antibodies to GD1a and GM1 gangliosides in elderly people

Plasmatic Ganglioside Profile and Age-Related Macular Degeneration: A Case-Control Study

Reduced raft‐association of NF155 in active MS‐lesions is accompanied by the disruption of the paranodal junction

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