Serum igG antibodies to GD1a and GM1 gangliosides in elderly people

Kolyovska, Vera

doi:10.18097/pbmc20166201093

Cited by 4 publications

(8 citation statements)

References 10 publications

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“…It has been hypothesized than neuroplastin depends on the lipid environment (Ilic et al., 2019), so we analyzed it together with GM1 and GD1a gangliosides. The two gangliosides were studied together because GD1a acts as a reservoir of GM1–GM1 can be synthesized from GD1a apart from its classical synthesis (Miyagi & Yamaguchi, 2012; Sonnino et al., 2011) and it was previously found to be implicated in neurodegenerative processes (Chiricozzi et al., 2020; Kolyovska, 2016). GD1a concentration in the frontal brain decreases with aging (Svennerholm et al., 1989), and a similar decrease was observed in AD patients, especially in the hippocampus (Mesa‐Herrera et al., 2019; Svennerholm, 1994).…”

Section: Discussionmentioning

confidence: 99%

Disarranged neuroplastin environment upon aging and chronic stress recovery in female Sprague Dawley rats

Balog

Blažetić

Ivić

et al. 2021

Eur J of Neuroscience

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Chronic stress produces long‐term metabolic changes throughout the superfamily of nuclear receptors, potentially causing various pathologies. Sex hormones modulate the stress response and generate a sex‐specific age‐dependent metabolic imprint, especially distinct in the reproductive senescence of females. We monitored chronic stress recovery in two age groups of female Sprague Dawley rats to determine whether stress and/or aging structurally changed the glycolipid microenvironment, a milieu playing an important role in cognitive functions. Old females experienced memory impairment even at basal conditions, which was additionally amplified by stress. On the other hand, the memory of young females was not disrupted. Stress recovery was followed by a microglial decrease and an increase in astrocyte count in the hippocampal immune system. Since dysfunction of the brain immune system could contribute to disturbed synaptogenesis, we analyzed neuroplastin expression and the lipid environment. Neuroplastin microenvironments were explored by analyzing immunofluorescent stainings using a newly developed Python script method. Stress reorganized glycolipid microenvironment in the Cornu Ammonis 1 (CA1) and dentate gyrus (DG) hippocampal regions of old females but in a very different fashion, thus affecting neuroplasticity. The postulation of four possible neuroplastin environments pointed to the GD1a ganglioside enrichment during reproductive senescence of stressed females, as well as its high dispersion in both regions and to GD1a and GM1 loss in the CA1 region. A specific lipid environment might influence neuroplastin functionality and underlie synaptic dysfunction triggered by a combination of aging and chronic stress.

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Section: Discussionmentioning

confidence: 99%

Disarranged neuroplastin environment upon aging and chronic stress recovery in female Sprague Dawley rats

Balog

Blažetić

Ivić

et al. 2021

Eur J of Neuroscience

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“… 4,5,10–15 Besides GBS, IgG anti‐GM1 antibodies have also been reported in several other conditions (Table 2). 4,5,16–28 …”

Section: Gm1 and Molecular Mimicrymentioning

confidence: 99%

“…4,5,[10][11][12][13][14][15] Besides GBS, IgG anti-GM1 antibodies have also been reported in several other conditions (Table 2). 4,5,[16][17][18][19][20][21][22][23][24][25][26][27][28] Campylobacter jejuni, a Gram-negative rod bacterium, is the first epidemiologically proven agent in antecedent infections of GBS, 29,30 and most patients with GBS after C. jejuni enteritis have axonal disturbance. 29,31 This bacterium can biosynthesize ganglioside-like glycans on its lipo-oligosaccharide (LOS) bacterial surface, 32 and GBS after C jejuni enteritis has become an excellent model for demonstrating the causal pathogenesis of molecular mimicry between microbial antigens and host tissue: some C jejuni strains carry GM1like molecules that induce a transient production of IgG antibodies cross-reacting with GM1, thereby causing axonal GBS.…”

Section: G M1 and Molecul Ar Mimi Crymentioning

confidence: 99%

“…H. influenzaerelated GBS showed better outcomes compared with C. jejunirelated GBS, suggesting that the type of antecedent infection, which is upstream of GBS pathogenesis, is the main determinant of GBS prognosis in anti-GM1 antibody-positive GBS. 47 The relationship between the antecedent infection and prognosis could be mediated by the diverse IgG subclasses and fine specificity, but other mechanisms could also be hypothesized, including variations in the ability to activate complement, antibody affinity to the GM1 antigen, binding of the Fcγ-receptor and host factors that influence autoreactivity TA B L E 2 Reported conditions associated with immunoglobulin G anti-GM1 antibodies -GBS: especially axonal GBS manifesting as acute motor axonal neuropathy 4,5,16 or distal limb weakness 17 -"Lower motor neuron syndrome" 18 -Chronic inflammatory demyelinating polyneuropathy 19 -Systemic lupus erythematosus 20 -Sjögren's syndrome 20 -Mixed cryoglobulinemia 20 -Various disorders (case reports): Acute inflammatory encephalomyelitis 21 Critical illness polyneuro(myo)pathy 22 Epilepsy (partial) 23 Hirayama disease 24 Malignant melanoma 25 Multiple sclerosis 26 -After administration of gangliosides as therapy 27 -Older persons (aged >80 years) 28 Abbreviation: GBS, Guillain-Barré syndrome TA B L E 3 Unsolved issues about the pathogenic role of immunoglobulin G anti-GM1 antibodies in Guillain-Barré syndrome to infections. In summary, antecedent infections could be a source of variation for severity in anti-GM1-positive GBS patients, and serve as a possible answer for the first unsolved issue in Table 3, which might further be mediated by other factors, including fine specificity, IgG subclass or others, as described in detail in other parts of this article.…”

Section: Antecedent Infec Ti On Smentioning

confidence: 99%

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Multifaceted features of immunoglobulin G anti‐GM1 antibodies in Guillain–Barré syndrome

Koga

2021

Clinical & Exp Neuroim

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Immunoglobulin G (IgG) anti‐GM1 antibodies, the most common autoantibodies in Guillain–Barré syndrome (GBS), have diverse characteristics regarding IgG subclass, complement activation, affinity and fine specificity. In this review, an update on multifaceted aspects of IgG anti‐GM1 antibodies is provided, emphasizing their roles in creating a varying clinical picture of GBS and in developing pure motor neuropathy after antecedent infection. Diversity in IgG subclass and cross‐reactivity, both of which are closely related to the type of antecedent infection, appears to cause the variation in clinical features and severity of the disease. The environment around GM1 expression in neural tissue is thought to interfere with the binding of anti‐GM1 antibodies by modulating the immunoreactive epitope, allowing only anti‐GM1 antibodies with specific fine specificity to bind to the GM1 ganglioside. This might create the characteristic clinical picture of pure motor neuropathy in anti‐GM1‐positive GBS, although GM1 is present equally in motor and sensory nerves. The environment around the GM1 epitope on Campylobacter jejuni, the most frequently identified agent in antecedent infections of GBS, might also be important in creating diversity in the fine specificity of anti‐GM1 antibodies, possibly preventing the development of GBS in most patients with enteritis by the GM1 epitope‐bearing C. jejuni. Because there remains no direct evidence indicative that diversity of anti‐GM1 antibodies is involved in the development of GBS, further study is required.

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“…Gangliosides are found mainly in the neurons but also occur in smaller concentration in other cell types. The ganglioside spectra of normal blood plasma are remarkably stable, but show pronounced changes in pathological conditions [5]. The main gangliosides in the human central nervous system myelin are monosialogangliosides GM1 [6].…”

Section: Introductionmentioning

confidence: 99%

Demyelination and neurodegenerative changes in serum IgG antibodies to GM1, GD1a and GM3 gangliosides in a patient on dialysis

Kolyovska¹,

Pavlova²,

Илиев³

et al. 2017

Neurol Disord Therap

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During the last two decades, an enormous effort has been made to discover biological markers of neuronal damage to effective response to therapy. Gangliosides a family of acidic glycosphingolipids are highly represented in the nervous system. Their spectra show considerable changes in pathological conditions. The complex of anti-ganglioside antibodies may be useful diagnostic and prognostic tool of markers for demyelination (GM1), neurodegeneration (GD1a)and(GM3) correlates with the loss of integrity of the blood brain barrier (BBB). Additionally, patients with renal failure may manifest a variety of neurologic disorders.Dialysis itself is associated with at least three distinct disorders of the central nervous system, including the dialysis disequilibrium syndrome, dialysis dementia, and progressive intellectual dysfunction. Our case studyinvolves a patient on dialysis, a 72-years old woman, as an example of long-term toxicity. She was on dialysis for 1,5 years. The values of IgG anti-GM1, anti-GD1a and anti-GM3 antibodies titers in the blood serum were detected by ELISA. Significantly elevated serum IgG anti-GM1 antibodies titers were detected in our patient. The value of the titer of IgG antibodies against GM1 showed the presence of weak demyelination, increasing with dialysis treatment but not neurodegeneration. On the other hand, other biomarkers were indicative of the preserved integrity of the BBB since IgG titers of antiGD1a and anti-GM3 antibodies were in norm.The patient had many signs that show and prove symptoms of encephalopathy.Neurologic findings in the patients with uremic encephalopathy (UE) range from normal to a comatose state. Neurologic diseases which are specifically related to uremia and/or dialysis occur with increased frequency in patients with end-stage renal disease on chronic hemodialysis. These include subdural hematoma, electrolyte disorders, vitamin deficiencies, drug intoxication, hypertensive encephalopathy, and acute trace element intoxication. Our observations show that there is a relationship between kidney problems and central nervous system (CNS).

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Serum igG antibodies to GD1a and GM1 gangliosides in elderly people

Cited by 4 publications

References 10 publications

Disarranged neuroplastin environment upon aging and chronic stress recovery in female Sprague Dawley rats

Disarranged neuroplastin environment upon aging and chronic stress recovery in female Sprague Dawley rats

Multifaceted features of immunoglobulin G anti‐GM1 antibodies in Guillain–Barré syndrome

Demyelination and neurodegenerative changes in serum IgG antibodies to GM1, GD1a and GM3 gangliosides in a patient on dialysis

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