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Sivagnanam, Soupramanien; Deleu, Dirk

doi:10.1186/cc1871

Cited by 155 publications

(62 citation statements)

References 17 publications

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“…It typically occurs when vancomycin is administered parenterally, but there have been case reports of red man syndrome occurring when vancomycin is administered orally [71,72,73]. The syndrome usually involves symptoms of pruritus, flushing and an erythematous rash that involves the upper body and neck [74]. Hypotension, chest pain and muscle cramping have also been reported with this syndrome [75,76].…”

Section: Vancomycinmentioning

confidence: 99%

Nonallergic Drug Hypersensitivity Reactions

Farnam

Chang

Teuber

et al. 2012

Int Arch Allergy Immunol

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Background: Nonallergic drug hypersensitivities, also referred to as pseudoallergic or anaphylactoid reactions, have clinical manifestations that are often indistinguishable from allergic reactions. Methods: We performed a PubMed search using the terms ‘drug allergy, drug hypersensitivity, pseudoallergies, anaphylaxis and nonallergic drug reactions’ and reviewed 511 publications dated between 1970 and 2012. A total of 160 papers that were relevant to the most common nonallergic drug hypersensitivity reactions were selected for discussion. Results: Nonallergic drug hypersensitivities do not involve either IgE-mediated (type 1) or delayed (type 4) hypersensitivity. Nonallergic hypersensitivities are commonly referred to as pseudoallergic or idiosyncratic reactions. The common nonallergic drug hypersensitivities are secondary to chemotherapeutic drugs, radiocontrast agents, vancomycin, nonsteroidal anti-inflammatory agents, local anesthetic reactions and opiates. Protocols for skin testing of radiocontrast, nonsteroidal anti-inflammatory agents, local anesthetics and chemotherapeutic agents have been developed, though most have not been validated or standardized. Other diagnostic tests include in vitro-specific IgE tests, and the current ‘gold’ standard is usually an oral challenge or bronchoprovocation test. In the case of aspirin, even though it is not believed to be IgE-mediated, a ‘desensitization’ protocol has been developed and utilized successfully, although the mechanism of this desensitization is unclear. Conclusions: Diagnostic methods exist to distinguish allergic from nonallergic drug hypersensitivity reactions. The best option in nonallergic drug hypersensitivity is avoidance. If that is not possible, premedication protocols have been developed, although the success of premedication varies amongst drugs and patients.

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Section: Vancomycinmentioning

confidence: 99%

Nonallergic Drug Hypersensitivity Reactions

Farnam

Chang

Teuber

et al. 2012

Int Arch Allergy Immunol

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“…Antibiotics such as ciprofloxacin, amphotericin B, rifampicin and teicoplanin can potentially cause red man syndrome 9 . Red man syndrome is aggravated in patients receiving vancomycin with opioid analgesics or muscle relaxants 4 . The adverse effect of red man syndrome can be relieved by antihistamines.…”

Section: Case Reportmentioning

confidence: 99%

“…Agitation, dizziness, headache, chills, fever and perioral paresthesia are also described 3 . In severe cases patients complain of chest pain and dyspnoea 4 . Although the reaction is more likely to occur with rapid intravenous infusion of vancomycin, it may also occur when infusion is given at slower rate.…”

Section: Introductionmentioning

confidence: 99%

“…Although the reaction is more likely to occur with rapid intravenous infusion of vancomycin, it may also occur when infusion is given at slower rate. If the symptoms consistent with this type of reaction occur, slowing the rate of infusion for at least over two hours and pre-treating with a histamine-1 antagonist prior to any subsequent doses of vancomycin is recommended 4 . Vancomycin-impregnated polymethyl methacrylate beads are commonly being used in orthopaedics for the treatment of Methicillin-Resistant S. Aureus osteomyelitis with efficacy reported 5 .…”

Section: Introductionmentioning

confidence: 99%

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Red man syndrome: an unusual complication of vancomycin beads

Juyal

Khurana

Maheshwari

2015

Bangladesh J Med Sci

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Abstract:Vancomycin is a bactericidal antibiotic. It is commonly used to treat Methicillin Resistant Staphylococcus Aureus (MRSA) infections. It is also used locally with Polymethyl methacrylate to treat chronic bone infections. Locally placed beads deliver high concentration of antibiotics locally with few adverse effects as compared to parenteral therapy. There are two complications mentioned on intravenous infusion of vancomycin namely anaphylactic reaction and red man syndrome; but there is no known literature on complications arising from vancomycin impregnated cement beads. We report a case of red man syndrome following usage of vancomycin impregnated cement beads which is not reported in any available orthopaedic literature.

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“…Red man syndrome (RMS), an anaphylactoid reaction, is caused by the degranulation of mast cells and basophils, resulting in the release of histamine independent of preformed IgE or complement. [4] The extent of histamine release is related partly to the amount of drug administered. The characteristic signs of RMS include: Orange-red discoloration of the skin, urine, and tears, facial pruritus, and periorbital edema.…”

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confidence: 99%