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Straathof, Jan Willem; Lamers, C. B. H. W.; Masclee, Ad

doi:10.1023/a:1018872814428

Cited by 31 publications

(6 citation statements)

References 14 publications

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“…[14–17] Moreover, individuals with impaired renal function have elevated serum gastrin levels due to reduced excretion and impaired metabolism in the liver degradation of gastrin. [1416–19] Straathof et al [20] reported that postprandial plasma concentrations of gastrin, in addition to its effect on gastric acid secretion, decrease LES pressure and increase the transient LES relaxations associated with reflux. These factors collectively may explain the higher prevalence of GERD in our group of patients with ESRD.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of gastroesophageal reflux disease and its association with Helicobacter pylori infection in chronic renal failure patients and in renal transplant recipients

Abdul-Rahman

Al-Quorain

2008

Saudi J Gastroenterol

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Background/Aims:The prevalence of gastroesophageal reflux disease (GERD) in chronic renal failure patients and in renal transplant recipients (RTR) has been a subject of discussion in the last few years. Our aims are to clarify this association and its relation to Helicobacter pylori infection, and also to identify possible pathogenic factors in the development of this disease in both groups.Methods:The study involved 40 end-stage renal disease (ESRD) patients with upper gastrointestinal (GI) symptoms (group I), 36 patients who had undergone kidney transplantation and had similar symptoms (group II), and 44 age- and sex-matched controls with the same upper GI symptoms (group III). All patients were subjected to esophagogastroduodenoscopy, and biopsies were obtained from the antrum for histological evaluation and identification of H. pylori.Results:The prevalence of GERD in the first two groups was similar (77.5 vs. 75.0%, P = 0.412), while it was significantly lower in the control group (38.6%, P < 0.01). H. pylori infection was present in 40.0, 36.1 (P > 0.05) and 75% (P < 0.01 and < 0.001) of the patients in groups I, II, and III, respectively. Multivariate logistic regression analysis in groups I and II showed that high serum creatinine (Odds ratio [OR] = 6.78, 95% Confidence Interval (CI) = 1.12-45.82), immunosuppressive therapy (OR = 5.78, 95% CI = 1.01-32.5), and absence of H. pylori infection (OR = 3.58, 94% CI = 1.11-18.6) were significantly associated with GERD. The duration of ESRD correlated significantly with the prevalence of GERD in group I.Conclusions:This study showed a similar prevalence of H. pylori infection and GERD in ESRD and RTR patients. GERD prevalence was higher in these two groups than in the controls. Renal transplantation, chronic renal disease, immunosuppressive therapy, and the absence of H. pylori infection seem to be risk factors for the development of GERD.

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Section: Discussionmentioning

confidence: 99%

Prevalence of gastroesophageal reflux disease and its association with Helicobacter pylori infection in chronic renal failure patients and in renal transplant recipients

Abdul-Rahman

Al-Quorain

2008

Saudi J Gastroenterol

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“…It is likely that the physiological mechanism whereby type of carbohydrate and type of fat would influence AET and total number of reflux episodes is via stimulating the release of GI hormones such as ghrelin, gastrin, and glucagon-like peptide-1 that affect secretion of gastric acid and thereby decrease LES pressure and increase transient LES relaxations. 31 , 59 , 60 …”

Section: Resultsmentioning

confidence: 99%

“… 26 Other hormonal factors that may be involved in the relationship between dietary intake, overweight/obesity, and GERD include glucagon-like polypeptide 1 (GLP-1) signaling, which may inhibit gastric emptying, 27 , 28 and gastrin which stimulates acid release in the stomach and increases LES tone. 29 – 31 …”

Section: Introductionmentioning

confidence: 99%

Objective ambulatory pH monitoring and subjective symptom assessment of gastroesophageal reflux disease show type of carbohydrate and type of fat matter

Olszewski

Vaezi

et al. 2022

Therap Adv Gastroenterol

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Background: Rising prevalence of gastroesophageal reflux disease (GERD) in US Veterans is concurrent with increasing excess body weight. Objective: The objective of this cross-sectional study is to examine relationships between dietary macronutrients, gastrointestinal hormones, and GERD status. Methods: Ninety-eight veterans with overweight/obesity and empiric proton pump inhibitor (PPI) treatment were enrolled from the Tennessee Valley Healthcare System. Subjects had esophageal manometry and 24-h pH monitoring. Subjective symptoms were assessed with Gastroesophageal Reflux Disease Questionnaire (GERDQ) and Symptom Assessment Scale (GSAS). The primary outcomes, total acid exposure time (AET) and number of reflux episodes, enabled categorizing subjects as either pathologic GERD or inconclusive GERD. Data analysis included independent T-tests, Spearman Rho correlations, and multivariable linear regression modeling. Results: Higher intake of sugar-sweetened beverages (sugar-sweetened tea, soda, and fruit juice) associated with higher AET. Higher saturated-to-unsaturated fat intake is associated with higher AET and number of reflux episodes. Overall, sugar-sweetened beverage intake, saturated-to-unsaturated fat ratio, tomato-based food items, glucagon-like polypeptide 1 (GLP-1) level, time of first meal, and education status accounted for a significant amount of the variability in AET. Pathologic GERD subjects reported more heartburn ( p = 0.006), regurgitation ( p = 0.01), acid taste (0.001), and nausea severity ( p = 0.04). GERDQ score associated with AET ( r = 0.31, p = 0.005), but GSAS did not ( r = 0.12, p = 0.28). Conclusion: Of the many foods and nutrients tested, the type (not amount) of carbohydrate (simple sugars) and the type (not amount) of fat (saturated vs unsaturated fat) consumed associated with objective and/or subjective GERD testing. These novel findings contribute to the evidence base guiding specific dietary recommendations in the clinical management of GERD.

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“…The role of gastrin in the pathophysiology of GERD is related to its feedback on the lower esophageal sphincter (LES) mediated by cholecystokinin receptors. It leads to a decrease in LES pressure and to an increase in the percentage of transient LES relaxation episodes associated with GERD [16]. The main role of G-17 consists of the stimulation of gastric acid secretion mediated by a specific receptor on parietal cells.…”

Section: Discussionmentioning

confidence: 99%

Low Levels of Gastrin 17 are Related with Endoscopic Findings of Esophagitis and Typical Symptoms of GERD

Mario

Crafa

Franceschi³

et al. 2021

JGLD

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Background and Aims: In clinical practice, most patients with symptoms suggestive of gastroesophageal reflux disease (GERD) undergo esophago-gastro-duodenoscopy (EGD), despite its low sensitivity in detecting reflux stigmata. Gastrin 17 (G-17) has been proposed to be related with GERD, due to the negative feedback between acid secretion and this hormone. We assessed the clinical usefulness of fasting G-17 serum determination for a non-invasive diagnosis of GERD in patients with typical symptoms. Methods: We consecutively enrolled patients complaining of typical GERD symptoms in two different settings: a single referral center and a primary care setting. Control groups consisted of dyspeptic patients. All subjects underwent assessment of serum levels of G-17 and EGD. Results: At the academic hospital, 100 GERD patients (n=89 with erosive esophagitis and 11 with Barrett’s esophagus) had statistically significant low levels of G-17 as compared with 184 dyspeptic patients (1.7±1.2 pg/L vs 8.9±5.7 pg/L p<0.0001). Similarly, in the primary care setting, 163 GERD patients had statistically significant low levels of G-17 as compared with 132 dyspeptic patients (0.5±0.2 pg/L vs. 4.0±2.6 pg/L, p<0.0001). Moreover, in the primary care setting, no statistically significant differences were found for G-17 levels between patients with erosive and non-erosive reflux pattern (0.4±0.2 vs 0.7±0.3; p=0.08). In primary care, the accuracy of G-17 less than 1 pg/L to diagnose non-invasively GERD was 94.3%. Conclusions: Low levels of G-17 were detected in patients with erosive esophagitis and Barrett’s esophagus in a referral center and in patients with typical GERD symptoms in a sample of patients from a primary care setting.

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Cited by 31 publications

References 14 publications

Prevalence of gastroesophageal reflux disease and its association with Helicobacter pylori infection in chronic renal failure patients and in renal transplant recipients

Prevalence of gastroesophageal reflux disease and its association with Helicobacter pylori infection in chronic renal failure patients and in renal transplant recipients

Objective ambulatory pH monitoring and subjective symptom assessment of gastroesophageal reflux disease show type of carbohydrate and type of fat matter

Low Levels of Gastrin 17 are Related with Endoscopic Findings of Esophagitis and Typical Symptoms of GERD

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