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doi:10.1002/lsm.v40:10

Cited by 12 publications

(4 citation statements)

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“…Only with sufficient massage during OCAs application can significant optical clearing effect be achieved. Rylander et al 38 reported that tissue compression induced by mechanical force leads to a reduction of scattering in tissues. Thus, the mechanical force of massage itself can yield an optical clearing effect if compression is kept constant.…”

Section: Discussionmentioning

confidence: 99%

Enhanced optical clearing of skin in vivo and optical coherence tomography in-depth imaging

et al. 2012

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The strong optical scattering of skin tissue makes it very difficult for optical coherence tomography (OCT) to achieve deep imaging in skin. Significant optical clearing of in vivo rat skin sites was achieved within 15 min by topical application of an optical clearing agent PEG-400, a chemical enhancer (thiazone or propanediol), and physical massage. Only when all three components were applied together could a 15 min treatment achieve a three fold increase in the OCT reflectance from a 300 μm depth and 31% enhancement in image depth Z(threshold).

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Section: Discussionmentioning

confidence: 99%

Enhanced optical clearing of skin in vivo and optical coherence tomography in-depth imaging

et al. 2012

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“…Few in vitro studies have so far analyzed VEGF release after laser irradiation on several cell phenotypes, such as human endothelial cells, smooth muscle cells, cardiomyocytes, dermal or gingival fibroblasts, bone marrow derived mesenchymal stem cells, or olfactory glial cells. [24][25][26][27][28][29][30] No study has investigated laser effects on VEGF expression using osteoblast-like cells. From our findings, it can be hypothesized that a single laser irradiation modulates VEGF release in a dose-dependent and time-delayed manner.…”

Section: Discussionmentioning

confidence: 99%

Different doses of low-level laser irradiation modulate thein vitroresponse of osteoblast-like cells

et al. 2014

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Because osteoblasts play a key role in bone remodeling and the influence of low-level laser therapy on this process is not clear, Saos-2 human osteoblast-like cells were irradiated by a gallium-aluminum-arsenide diode laser (915 nm) for 10, 48, 96, 193, and 482 s using doses 1, 5, 10, 20, and 50 J/cm2, respectively. A control group was not irradiated. Morphology, viability, and cytotoxicity analyses were carried out after 1 hr, 1 day, and 3 days. Deoxyribose nucleic acid (DNA) content and release of vascular endothelial growth factor (VEGF), receptor activator of nuclear factor kappa B ligand (RANKL), and osteoprotegerin (OPG) were evaluated. Viability was modulated by laser irradiation in a dose-dependent manner, with 10 J/cm2 inducing a biostimulatory response and 20 to 50 J/cm2 determining a bioinhibitory and cytotoxic effect. Accordingly, DNA content was generally increased for the 10 J/cm2 dose and decreased for the 50 J/cm2 dose. A rapid and transitory trend toward increased RANKL/OPG ratio and a tendency toward a delayed increase in VEGF release for doses of 1 to 10 J/cm2 was found. Further investigations using the biostimulatory dose of 10 J/cm2 emerged from this study are needed to establish the ideal treatment regimens in the laboratory as well as in clinical practice.

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“…that is pasted between the margins of the wound and finally irradiated with a NIR laser. [15][16][17][18][19] On heating, the ICG formulation coagulates and seals the wound, thus acting as a solder. 20 When the adhesion is mediated by the topical interposition of soldering material, this bonding technique is more properly referred to as laser soldering.…”

Section: Current Laser Tissue Bonding Strategiesmentioning

confidence: 99%

“…2,21 In this context, the use of semisolid polymer formulations such as polycaprolactone (PCL) and chitosan in the form of flexible films and scaffolds is one hopeful alternative. 18,[21][22][23] These materials, in addition to an intrinsic versatility in their fabrication process, hold the promise of good biocompatibility, biodegradability on a timescale of several days to months inside the body, and capacity to host functional chemicals, which attracts much interest for tissue repair and drug delivery purposes. 24,25 Moreover, some formulations exhibit antimicrobial and chemoactractant properties, which can support and accelerate the wound healing process.…”

Section: Current Laser Tissue Bonding Strategiesmentioning

confidence: 99%

Emerging concepts of laser-activated nanoparticles for tissue bonding

Matteini

Ratto²,

Rossi³

et al. 2012

J. Biomed. Opt.

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We report recent achievements and future perspectives of minimally invasive bonding of biological tissues triggered by laser light. In particular, we review new advancements in the biomedical exploitation of near-infrared absorbing gold nanoparticles as an original solution for the photothermal closure of surgical incisions. Advanced concepts of laser tissue bonding involving the application of hybrid nanocomposites obtained by inclusion of nanochromophores into biopolymer scaffolds are also introduced. The perspectives of tissue bonding are discussed in the following aspects: (1) tissue bonding with highly-stabilized nanochromophores, (2) enhanced tissue bonding with patterned nanocomposites, (3) real-time monitoring of temperature distributions, (4) tracking of tissue regeneration based on the optical resonances of gold nanoparticles.

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Cited by 12 publications

References 0 publications

Enhanced optical clearing of skin in vivo and optical coherence tomography in-depth imaging

Enhanced optical clearing of skin in vivo and optical coherence tomography in-depth imaging

Different doses of low-level laser irradiation modulate thein vitroresponse of osteoblast-like cells

Emerging concepts of laser-activated nanoparticles for tissue bonding

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