Emerging concepts of laser-activated nanoparticles for tissue bonding

Abstract

We report recent achievements and future perspectives of minimally invasive bonding of biological tissues triggered by laser light. In particular, we review new advancements in the biomedical exploitation of near-infrared absorbing gold nanoparticles as an original solution for the photothermal closure of surgical incisions. Advanced concepts of laser tissue bonding involving the application of hybrid nanocomposites obtained by inclusion of nanochromophores into biopolymer scaffolds are also introduced. The perspectives of tissue bonding are discussed in the following aspects: (1) tissue bonding with highly-stabilized nanochromophores, (2) enhanced tissue bonding with patterned nanocomposites, (3) real-time monitoring of temperature distributions, (4) tracking of tissue regeneration based on the optical resonances of gold nanoparticles.

Conjugation of Antibodies to Gold Nanorods through Fc Portion: Synthesis and Molecular Specific Imaging

“…(1-28) In general, plasmonic nanoparticles are intrinsically multimodal contrast agents since they exhibit strong scattering and absorption cross sections as well as non-linear optical phenomena such as two-photon luminescence and second harmonic generation when excited at the plasmon resonance frequency. Gold nanoparticles provide high contrast in cellular and tissue imaging using confocal reflectance microscopy,(1, 29) dark-field imaging,(7, 29-32) two-photon luminescence(33-35) phase-sensitive OCT,(17) and photoacoustic imaging.…”

The Combination of Laser Therapy and Metal Nanoparticles in Cancer Treatment Originated From Epithelial Tissues: A Literature Review

“…The absorption peak of gold nanoparticles can be modulated by creating different shapes and size. 73,74 Another investigated wavelength was in the visible light spectra: 420 nm up to 690 nm. 3,15,21,33,35,38,46,56,70 The appplication of this wavelength was mostly in generating nanobubbles 15,33,35,38,46 …”

Polarized light Monte Carlo simulations of Depolarization contrast from Gold Nanoparticles

“…Gold nanoparticles have been probed as contrast agents in Optical Coherence Tomography and Photoacoustic Tomography [2]. There is also research depicting the use of gold nanoparticles for therapy such as laser bonding [3]. The polarized light interaction in a turbid media is investigated using simulations studies.…”