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Meinzer, Marcus; Elbert, Thomas; Wienbruch, Christian; Djundja, Daniela; Barthel, Gabriela; Rockstroh, Brigitte

doi:10.1186/1741-7007-2-20

Cited by 135 publications

(55 citation statements)

References 30 publications

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“…RI was accompanied by a suppression of spontaneous oscillatory activity in the delta band (1.3e4.0 Hz) while no change was seen in controls, linking delta suppression with suppression of tinnitus (also see Adjamian et al, 2012). Because increased delta activity has been observed in tinnitus and other deafferentation syndromes (Weisz et al, 2005;De Jongh et al, 2003;Meinzer et al, 2004;Vieth et al, 1996) and has been linked by one report with increased gamma oscillations in the auditory cortex of tinnitus sufferers (Weisz et al, 2007), Kahlbrock and Weisz suggested that suppression of delta activity may be a prerequisite for attenuation of the tinnitus sensation after masking. The hypothesis advanced by Kahlbrock and Weisz (2008) to explain RI (normalization of neural network activity in auditory cortex by masking) is similar to the hypothesis proposed here (suppression of hypersynchrony in the TFR) to explain the increase in ASSR amplitude evoked by 5 kHz probes after masking in the tinnitus group probed at this frequency but not in their controls.…”

Section: Other Electrophysiological Responses In Tinnitus and Rimentioning

confidence: 94%

Evidence for differential modulation of primary and nonprimary auditory cortex by forward masking in tinnitus

et al. 2015

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It has been proposed that tinnitus is generated by aberrant neural activity that develops among neurons in tonotopic of regions of primary auditory cortex (A1) affected by hearing loss, which is also the frequency region where tinnitus percepts localize (Eggermont and Roberts 2004; Roberts et al., 2010, 2013). These models suggest (1) that differences between tinnitus and control groups of similar age and audiometric function should depend on whether A1 is probed in tinnitus frequency region (TFR) or below it, and (2) that brain responses evoked from A1 should track changes in the tinnitus percept when residual inhibition (RI) is induced by forward masking. We tested these predictions by measuring (128-channel EEG) the sound-evoked 40-Hz auditory steady-state response (ASSR) known to localize tonotopically to neural sources in A1. For comparison the N1 transient response localizing to distributed neural sources in nonprimary cortex (A2) was also studied. When tested under baseline conditions where tinnitus subjects would have heard their tinnitus, ASSR responses were larger in a tinnitus group than in controls when evoked by 500 Hz probes while the reverse was true for tinnitus and control groups tested with 5 kHz probes, confirming frequency-dependent group differences in this measure. On subsequent trials where RI was induced by masking (narrow band noise centered at 5 kHz), ASSR amplitude increased in the tinnitus group probed at 5 kHz but not in the tinnitus group probed at 500 Hz. When collapsed into a single sample tinnitus subjects reporting comparatively greater RI depth and duration showed comparatively larger ASSR increases after masking regardless of probe frequency. Effects of masking on ASSR amplitude in the control groups were completely reversed from those in the tinnitus groups, with no change seen to 5 kHz probes but ASSR increases to 500 Hz probes even though the masking sound contained no energy at 500 Hz (an "off-frequency" masking effect). In contrast to these findings for the ASSR, N1 amplitude was larger in tinnitus than control groups at both probe frequencies under baseline conditions, decreased after masking in all conditions, and did not relate to RI. These results suggest that aberrant neural activity occurring in the TFR of A1 underlies tinnitus and its modulation during RI. They indicate further that while neural changes occur in A2 in tinnitus, these changes do not reflect the tinnitus percept. Models for tinnitus and forward masking are described that integrate these findings within a common framework.

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Section: Other Electrophysiological Responses In Tinnitus and Rimentioning

confidence: 94%

Evidence for differential modulation of primary and nonprimary auditory cortex by forward masking in tinnitus

et al. 2015

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“…The patient was tested before (pre) and after (post) a short-term intensive (experimental) language training (Constraint-Induced Aphasia Therapy, CIAT, Meinzer et al, 2005;Pulvermueller et al, 2001) that was accomplished in German. The development of CIAT has been guided by neuroscientific knowledge about cortical plasticity and includes a heavy training schedule (3 h/day on 10 consecutive workdays) within a motivating setting.…”

Section: Language Training and Testingmentioning

confidence: 99%

“…In a first fMRI scan, naming of visually presented objects was required in German and French in order to investigate cortical activation accompanying word-retrieval as a function of the long-term rehabilitation efforts. Then, the patient participated in a 2-week intensive (German) language training (Meinzer, Djundja, Barthel, Elbert, & Rockstroh, 2005;Pulvermueller et al, 2001). Special emphasis was given to word-retrieval in this training.…”

Section: Introductionmentioning

confidence: 99%

Recovery from aphasia as a function of language therapy in an early bilingual patient demonstrated by fMRI

et al. 2007

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Knowledge about the recovery of language functions in bilingual aphasic patients who suffer from left-hemispheric stroke is scarce. Here, we present the case of an early bilingual patient (German/French) with chronic aphasia. Functional magnetic resonance imaging (fMRI) was used to investigate neural correlates of language performance during an overt picture naming task in German and French (a) 32 months after stroke to assess differential recovery of both languages as a function of the preceding language therapy that was provided exclusively in German and (b) after additional short-term intensive (German) language training. At the first investigation behavioral performance confirmed selective recovery of German naming ability which was associated with increased functional brain activation compared to the French naming condition. Changes in behavioral performance and brain activation pattern as disclosed by fMRI after an additional experimental treatment were confined to the trained (German) language and indicate bilateral neuroplastic reorganization. No generalization to the untrained (French) language was observed. The present case results demonstrate use and/or training-dependent differential recovery of expressive language functions and an enhanced pattern of brain activation as a function of the rehabilitation efforts that were focussed exclusively on the patient's German language abilities.

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“…An important characteristic of neurons is the ability to form new connections and the more frequent neurons are active simultaneously, the stronger their connections become (Hebbian learning) (Kleim & Jones, 2008;Pulvermüller & Berthier, 2008). By increasing the intensity of impairment-based treatment, enhancement of neuronal connections can be achieved in the preferred left hemispheric lesional and perilesional areas in both the acute and chronic stage of stroke, and this has been related to a favourable outcome (Belin et al, 1996;Davis & Harrington, 2006;Fridriksson, Richardson, Fillmore, & Cai, 2012;Léger et al, 2002;Mattioli et al, 2014;Meinzer et al, 2004;Rochon et al, 2010).…”

Section: Introductionmentioning

confidence: 97%

Aphasia therapy early after stroke: behavioural and neurophysiological changes in the acute and post-acute phases

et al. 2015

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Background: There is reasonable evidence to suggest that speech and language therapy can be effective in the chronic stages of stroke recovery. However, the active ingredients remain unknown and several variables can influence therapy outcome, such as content, type, and amount of therapy. Neurophysiological measures, event-related brain potentials such as the N400 and P300, have shown to be sensitive markers of therapeutic effects. As a supplement to the usual behavioural evaluation methods, neurophysiological measures might help to further disentangle the effect of content, type, and/or amount of therapy. Aims: The present single case study aims to investigate the effect of language therapy by combining behavioural and neurophysiological outcome measures in a patient with aphasia during the acute and post-acute stage after stroke. By further subdividing the therapy period into different therapy blocks, possible influences of content, type, and/or amount of therapy are investigated. Methods & Procedures: RL is a 47-year-old man with a moderate non-fluent aphasia, who received three periods of therapy in the first fourmonths after his stroke. The initial evaluation moment occurred 10days post-stroke. First, he received an intensive language treatment of 30hr in 3weeks, which was followed by a conventional treatment of 30hr in 7weeks. Then, RL received a second, intensive language therapy of 30hr in 3weeks. This was followed by a period of 6months without any form of language treatment. Behavioural and neurophysiological measures were collected after every therapy and therapy-free period. The effect of therapy was examined by comparing the whole therapy period with the therapy-free period, without differentiating between the intensive and conventional treatment. In a second analysis, a comparison was made between the intensive therapy periods and the conventional therapy programme. Outcomes & Results: RL showed a general improvement on both behavioural and neurophysiological measures after the whole therapy period, which was preserved throughout the therapy-free period. Intensive treatment yielded better language outcomes as indicated by a behavioural and neurophysiological improvement in contrast with the behavioural deterioration of auditory discrimination of pseudowords and decline of the N400 neurophysiological marker, after the conventional therapy. Conclusions: The present study demonstrates the outcome of early language treatment after stroke in which intensity can play an important role. In addition, the use of neurophysiological outcome measures provides added value to the behavioural evaluations in the context of therapeutic follow-up

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Cited by 135 publications

References 30 publications

Evidence for differential modulation of primary and nonprimary auditory cortex by forward masking in tinnitus

Evidence for differential modulation of primary and nonprimary auditory cortex by forward masking in tinnitus

Recovery from aphasia as a function of language therapy in an early bilingual patient demonstrated by fMRI

Aphasia therapy early after stroke: behavioural and neurophysiological changes in the acute and post-acute phases

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