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Sallam, Hassan; Sadek, Sameh; Agameya, Abdel-Fattah

doi:10.1023/a:1024865725713

Cited by 52 publications

(7 citation statements)

References 20 publications

(45 reference statements)

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“…The findings were similar to those of Edirisinghe et al [19], but were in disagreement with two meta-analyses of different methods of AH by Edi-Osagie et al and Sallam et al that showed a positive trend for patients with repeated implantation failure [20][21][22].…”

Section: Discussionsupporting

confidence: 56%

Effect of laser assisted hatching on outcome of assisted reproductive technology

Elhussieny¹,

Mandouh²,

Hanafi³

et al. 2013

OJOG

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Objective: To determine whether laser-assisted hatching can improve clinical outcome of assisted reproductive techniques in both unselected patients and patients with advanced female age, with recurrent implantation failure, or who are using frozen-thawed embryos. Study design: Prospective randomized study. Patients and methods: 179 consecutive women scheduled for intracytoplasmic sperm injection (ICSI) were randomised to either laser assisted hatching (LAH) or non LAH group. Patients were divided into 94 test and 85 control groups. On the day of embryo transfer, the zona pellucida of the selected embryos in the test group was thinned by using an infrared optical laser system, whereas in the control group they were left intact. Clinical pregnancy rates (CPR) and implantation rates (IR) were estimated. Result(s): Patients that underwent LAH (n = 94) had CPR, and IR of 35.1% and 50%, respectively. Patients that did not undergo LAH (n = 85) had lower CPR (28.2%, P = 0.324) and IR (33%, P = 230), with no statistically significant difference P < 0.05. Conclusion: The current study suggested that there is no need for the routine use of laser assisted hatching. However, there is evidence of laser assisted hatching benefit in selected patients

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Section: Discussionsupporting

confidence: 56%

Effect of laser assisted hatching on outcome of assisted reproductive technology

Elhussieny¹,

Mandouh²,

Hanafi³

et al. 2013

OJOG

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“…Since the first-ever use of assisted hatching (AH) by Cohen et al [ 1 ], a variety of AH techniques have been used including zona thinning (ZT) and the opening or complete removal of the zona by chemical, mechanical, enzymatic, and/or laser-based methods [ 2 3 ]. Although many studies have reported an increased pregnancy outcome by facilitating the hatching process of embryos [ 4 5 6 7 8 9 ], some studies have found no effects or insufficient evidence to determine any effect of AH on live birth rates [ 10 11 ]. According to a literature review in 2008 by the American Society for Reproductive Medicine, there was no reason to recommend the routine performance of AH in women undergoing ART [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of laser-assisted multi-point zona thinning on development and hatching of cleavage embryos in mice

Lee

Park

et al. 2015

Clin Exp Reprod Med

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ObjectiveThis study aimed to examine the effect of laser-assisted zona thinning (LAZT) at one or four-points on the blastocyst formation and hatching process in mice with respect to female age.MethodsEight-cell or morula embryos collected from superovulated C57BL female mice with different ages (6-11 and 28-31 weeks) were treated with LAZT at one-point (LAZT1) or four-points (LAZT4). The zona pellucida was thinned to more than 70% of its initial thickness by making two holes of 15-20 µm.ResultsIn the young mice, LAZT resulted in a significant increase in early hatching and hatching rates compared to the control group (p<0.05). However, in the old mice, LAZT significantly increased blastocyst formation as well as early hatching and hatching compared to the controls (p<0.05). These effects were more remarkable in LAZT4 than in LAZT1 and in aged mice than in young ones.ConclusionThese results show that multi-point LAZT leads to a significant improvement of blastocyst formation and hatching in mice compared to controls.

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“…While there have been multiple reports comparing ART outcomes in cycles with and without AH, most have defined poor prognosis as prior failed cycles or based on maternal age rather than looking specifically at FSH concentration. Many such studies support a role for AH in improving clinical pregnancy rates in women who are at least 38 years old or who have had unsuccessful prior ART cycles; several studies have also demonstrated improvements in ongoing/live birth rates in these subpopulations (19–22, 36). In contrast, Assemi et al published a study more analogous to ours in its comparison of 154 initial ART cycles all with FSH >=10 IU/L according to whether AH was performed.…”

Section: Discussionmentioning

confidence: 88%

“…Since the publication of those initial reports, multiple approaches to thinning and breaching the zona pelucida have been proposed (11, 17). However, the data supporting the benefit of AH in ART cycles has been variable and contradictory (11, 19–25). Much of the data suggesting a benefit of AH has found improvements in cycles following prior IVF failures, cycles treating women at least 38 years of age, or cycles in which embryo quality is poor (11, 14, 26).…”

Section: Introductionmentioning

confidence: 99%

Assisted hatching and intracytoplasmic sperm injection are not associated with improved outcomes in assisted reproduction cycles for diminished ovarian reserve: an analysis of cycles in the United States from 2004 to 2011

Butts

Owen

Mainigi

et al. 2014

Fertility and Sterility

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Objective To investigate the impact of intracytoplasmic sperm injection (ICSI) and assisted hatching (AH) on ART outcomes in cycles with diminished ovarian reserve (DOR) as the primary diagnosis. Design Retrospective cohort study of cycles from the SART-CORS database. Setting NA. Patient(s) A total of 422,949 fresh, non-donor, initial ART cycles of which 8,597 were diagnosed with only elevated FSH and 38,926 were diagnosed with only DOR according to the SART DOR categorization. Intervention(s) None. Main Outcome Measure(s) Live birth and clinical pregnancy rates. Result(s) ICSI and AH were associated with diminished odds of live birth in SART DOR only cycles (AOR, 95% CI 0.88, 0.81–0.96 for ICSI; AOR, 95% CI 0.77 0.71–0.84 for AH). No association between either ICSI or AH in Elevated FSH only cycles was observed. The combination of ICSI and AH resulted in significantly lower odds of live birth in SART DOR only cycles but not in Elevated FSH only cycles. Conclusion(s) In initial ART cycles for which the only indication relates to a diagnosis of diminished ovarian reserve, assisted hatching and ICSI are not associated with improved live birth rates.

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Abstract: Assisted hatching increases the pregnancy, implantation, and ongoing pregnancy rates significantly in patients with a poor prognosis undergoing IVF or ICSI, particularly those with repeated failures.

Cited by 52 publications

References 20 publications

Effect of laser assisted hatching on outcome of assisted reproductive technology

Effect of laser assisted hatching on outcome of assisted reproductive technology

Effect of laser-assisted multi-point zona thinning on development and hatching of cleavage embryos in mice

Assisted hatching and intracytoplasmic sperm injection are not associated with improved outcomes in assisted reproduction cycles for diminished ovarian reserve: an analysis of cycles in the United States from 2004 to 2011

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