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Antitumor and antimetastatic effects of betulonic acid amides in mice with transplantable Lewis carcinoma

“…1). The test compounds were synthesized at the Laboratory of Medical Chemistry (Novosibirsk Institute of Organic Chemistry) [3].…”

Synthesis and antibacterial activity of betulonic acid amides with piperazine derivatives

“…It is an available and convenient starting material for synthesizing new biologically active compounds [3][4][5][6]. Compounds with antioxidant, anti-inflammatory, antibacterial, hepatoprotective, antiviral, antitumor, and immunostimulant properties have been found among the synthesized derivatives of betulonic acid [4,[7][8][9][10][11][12].…”

“…Betulonic acid chloride (1) was synthesized via reaction with oxalylchloride by the literature method [7]. The structure of 1 was confirmed by comparing its PMR and 13 C NMR spectra with the literature data [6]. Amides 2-7 were prepared via reaction of 1 with N-derivatives of piperazine in CH 2 Cl 2 (1:2 mole ratio) in the presence of NEt 3 (4 eq).…”

“…The yields of the target compounds were 74.9-89.8%. The structures of the amides were established using IR and NMR spectra and a comparison with those for analogous compounds [5,6,12]. The 13 C NMR spectra of the synthesized compounds 2-7 contained resonances for the betulonic moiety and the corresponding number of C resonances for the amine component (Table 1).…”

Effect of Betulonic Acid and Its Derivative [3-Oxo-20(29)-Lupene-28-Oyl]-3-Aminopropionic Acid on Liver Structure in Mice with RLS Lymphoma

“…Betulonic acid (BA) and its amide, containing β-alanine fragment in the lateral substitute: [3-oxo-20(29)-lupene-28-oyl]-3-aminopropionic acid (BA amide), were synthesized at Laboratory of Medical Chemistry, Novosibirsk Institute of Organic Chemistry [7]. These compounds exhibited antioxidant effect in mice and rats with toxic CCl 4 -induced hepatitis [9,10].…”