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Abstract

The effect of gamma-irradiation on the realization of the effects of estrogens was studied on rats treated with N-acetylcysteine, vitamins C and E, melatonin, and carnosine or subjected to forced swimming in a training mode. Irradiation (0.2 Gy) in combination with estrogens and without correction therapy induced genotoxic changes in the uterus, while irradiation in a higher dose (2 Gy) predominantly potentiated the hormonal effect of estrogens. Correction of the revealed abnormalities was achieved mainly with carnosine. The peculiarities of "estrogen toggle (re-targeting) effect" under the effect of gamma-irradiation and its elimination differed from those induced by ethanol intake or tobacco smoking, which is important for understanding the mechanisms of hormone-induced carcinogenesis.

Comparative study of postradiation genotoxic changes in mammalian cells by biochemical and cytogenetic methods

“…The distribution of endometrial cells by phases of the cell cycle and proliferation index remained practically unchanged in irradiated rats (0.2 Gy) [1]. MCTL in irradiated rats was much higher than in control animals (Fig.…”

“…The effect of radiation was studied in 59 female rats obtained from the Rappolovo nursery [1]. The animals were divided into 8 groups.…”

“…In the present work, we counted 100 cells from each rat. The mean length of the comet tail (MCTL) was calculated per cell [1]. Genotoxic changes in cells were also studied by a modified method based on calculation of the DNA index (DI).…”