Untitled

Stawińska, Justyna; Cieślak‐Golonka, Maria; Staszak, Zbigniew; Gancarz, Roman

doi:10.1023/a:1007108104803

Cited by 9 publications

(2 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…763 cm –1 and C–Cl stretching appears at 1038 cm –1 . Major changes occur in the bands of C=C and C=N ring stretching as they are shifted from 1578, 1419 to 1650, and 1491 cm –1 , respectively, supporting binding of metal atoms by nitrogen atoms of bipyridine skeleton, which was further supported by a sharp band at 589 and 479 cm –1 , characteristic bands of symmetric and asymmetric stretching of the Pt–N bond 19. The stretching mode of Pt–Cl is expected in the region below 400 cm –1 i.e.…”

Section: Resultsmentioning

confidence: 99%

Synthesis, Characterization, Covalent Binding, and Degree of Unwinding of Platinum(II) Bipyridine Complexes

Patel

Gandhi

Parmar

et al. 2012

Zeitschrift anorg allge chemie

View full text Add to dashboard Cite

The complexes [Pt(3′′‐clpbpy)Cl2] (1) [3′′‐clpbpy = 4‐(3′′‐chlorophenyl)‐6‐phenyl‐2, 2′‐bipyridine], [Pt(4′′‐clpbpy)Cl2] (2) [4′′‐clpbpy = 4‐(4′′‐chlorophenyl)‐6‐phenyl‐2, 2′‐bipyridine], [Pt(3′′‐brpbpy)Cl2] (3) [3′′‐brpbpy = 4‐(3′′‐bromophenyl)‐6‐phenyl‐2, 2′‐bipyridine], and [Pt(4′′‐brpbpy)Cl2] (4) [4′′‐brpbpy = 4‐(4′′‐bromophenyl)‐6‐phenyl‐2, 2′‐bipyridine] were synthesized and characterized. The binding of the complexes with herring sperm DNA (HS DNA) was investigated by absorption titration and viscosity measurements. It was found that the complexes have ability of interaction with DNA by covalent mode. The intrinsic binding constant Kb of the complexes with HS DNA is 8.76 × 104 (1), 9.89 ×104 (2), 1.52 × 105 (3), and 2.31 × 105 (4) M–1. The slight depression in relative specific viscosity was observed, which also attributes to covalent binding of complexes with DNA bases. Gel electrophoresis assay demonstrated the ability of the complexes to unwind negatively supercoiled pUC19 plasmid by 14° (1), 13° (2), 13° (3), and 11° (4). The in vitro cytotoxic property of the synthesized metal complexes was also carried out against brine shrimp bioassay.

show abstract

Section: Resultsmentioning

confidence: 99%

Synthesis, Characterization, Covalent Binding, and Degree of Unwinding of Platinum(II) Bipyridine Complexes

Patel

Gandhi

Parmar

et al. 2012

Zeitschrift anorg allge chemie

View full text Add to dashboard Cite

show abstract

“…The six carbons of the B-ring experienced obvious chemical shift changes due to the formation of the complex, in which only C-4c shifted to low field [27]. It may be assumed that the oxygen atom of C-4c-OH provides a pair of unshared electrons to the metal ion to form a coordination bond, and the redistribution of the electron cloud in the newly formed chelate ring shifted C-3c to high field [28], while the opposite case is true for C-4c, as shown in Fig. 2.…”

mentioning

confidence: 99%

Synthesis, Spectral and Antioxidant Properties of Tin(II)-Rutin Complex

et al. 2014

View full text Add to dashboard Cite

Rutin is one of the most common flavonoids present in nature that has a wide range of biological properties. A Tin(II)-rutin complex was synthesized from the raw material rutin and SnCl 2 in an alkaline solution. The complex was characterized by UV-vis, IR, 1 H NMR, and 13 C NMR spectroscopy. We evaluated the free radical scavenging activity using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method, and the results showed that pure rutin was more effective than the Tin(II)-rutin complex in terms of antioxidant activity. Supplementing diet by foods rich in rutin and other flavonoids, such as vegetables and fruits, may contribute to removing free radicals and heavy metal ions in our body.Tinplate, commonly known as tin-plated steel sheet, is a kind of cold-rolled low-carbon steel sheet coated with pure tin on both sides. This material combines the durable strength of steel with the corrosion resistance of tin in one. These characteristics are the reasons why tinplate is widely used in the manufacture of rigid containers, especially for food and beverage packaging. Normally the concentration of tin in the majority of foods should be less than 1 part per million (ppm); however, in canned foods, especially those with an acidic pH, noticeably higher levels or more may be found [e.g., 100-500 ppm (0.01-0.05%)]. Regular consumption of these foods will cause symptoms of tin poisoning, such as vomiting, diarrhea, and anorexia [1].Chelation therapy is the preferred method for reducing the heavy metal induced toxicity. Chelating agents tightly bind to toxic metal ions to form complex structures that are easily excreted from the body [2]. Flavonoids are polyphenolic natural products widely distributed in plant foods, with a wide range of biological activities and pharmacological properties such as cardiovascular protection, anti-cancer, anti-ulcer, anti-oxidation, anti-viral, and anti-inflammatory; in addition, flavonoids are also natural antioxidants, free radical scavengers, and metal chelators [3]. Rutin is one of the most common flavonoids present in nature that has a wide range of biological properties, such as anti-inflammatory [4], anticancer [5], antioxidant [6], and so on. Rutin is an effective metal chelator [7, 8]. The complexation of metal cations by rutin has already been reported for a large number of metals: Zn (II), Al (III) [9], Cu (II) [10], Co (II) [11], Fe (II) [12], Fe (III) [13], Mn (II) [14], V (II) [15], U (II) [16], and Au (III) [17]. Rutin has attracted the attention of many researchers because of these special properties [18]. Supplementing regular diet with foods rich in rutin and other flavonoids, such as ginkgo biloba and buckwheat, may contribute to removing free radicals and heavy metal ions in our body [19,20].The purpose of this investigation was to study the chelating properties of rutin with tin cations [Sn(II)] and investigate the variation in antioxidant properties of rutin after chelation.The UV-vis spectrum of free rutin and Tin(II)-rutin complex in MeOH is reported in Fig. 1. Rutin exhibit...

show abstract

Square Planar Platinum(II) Complexes with N,S-Donor Ligands: Synthesis, Characterisation, DNA Interaction and Cytotoxic Activity

Patel

Joshi

et al. 2013

Appl Biochem Biotechnol

View full text Add to dashboard Cite

The platinum(II) complexes with N,S-donor ligand have been synthesised and characterised by physiological techniques like elemental, electronic, Fourier transform infrared, hydrogen-1 nuclear magnetic resonance ((1)H NMR) and liquid chromatography-mass spectrometry spectra. The synthesised complexes have been checked for their DNA binding ability by absorption titration and viscosity measurement, and the results show that the complexes binds to herring sperm DNA (HS DNA) via covalent mode of binding. The DNA cleavage activity of synthesised complexes has been carried out by gel electrophoresis experiment using supercoiled form of pUC19 DNA, showing the unwinding of the negatively charged supercoiled DNA. Brine shrimp (Artemia cysts) lethality bioassay technique has been applied for the determination of toxic property of synthesised complexes in terms of micromolars.

show abstract

Untitled

Cited by 9 publications

References 22 publications

Synthesis, Characterization, Covalent Binding, and Degree of Unwinding of Platinum(II) Bipyridine Complexes

Synthesis, Characterization, Covalent Binding, and Degree of Unwinding of Platinum(II) Bipyridine Complexes

Synthesis, Spectral and Antioxidant Properties of Tin(II)-Rutin Complex

Square Planar Platinum(II) Complexes with N,S-Donor Ligands: Synthesis, Characterisation, DNA Interaction and Cytotoxic Activity

Contact Info

Product

Resources

About