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Abstract

Both underweight and overweight have negative effects on IVF parameters and outcome leading to decreased chances of pregnancy.

Comparison of embryological and clinical outcome in GnRH antagonist vs. GnRH agonist protocols for in vitro fertilization in PCOS non-obese patients. A prospective randomized study

“…In our study we managed to gather a homogeneous group of 70 BMI<26 PCOS women. By including only non-obese women with PCOS we decreased the risk of possible influence of metabolical disturbances and negative impact of the obesity on the oocyte number and the duration of the stimulation [13,14]. Furthermore, to study LH dynamics during COH in both protocols we decided to exclude BMI inhibitory effect on LH [25,26].…”

“…Meta-analysis by Griesinger et al showed similar benefits of GnRH analogs regarding PCOS populace [11]. On the other hand, meta-analyses mentioned above did not consider high body mass index (BMI) as an exclusion criteria, while current studies report obesity to be associated with relative gonadotropin resistance [12], lower number of collected oocytes [13,14] as well as general poorer IVF outcome [15]. According to the latest consensus on infertility treatment related to PCOS, the optimal stimulation protocol is still under debate [4].…”

Low grade inflammation, as evidenced by basal high sensitivity CRP, is not correlated to outcome measures in IVF

“…In the last decade, the relationship between body weight, subfertility and inflammatory markers like hs-CRP has been explored in some studies [3,4,24]. White adipose tissue plays a central role in the low grade inflammatory state that is characteristic of obesity [25,26].…”

“…Increase in maternal age is known to have a negative impact on fertility secondary to reduced ovarian reserve [1,2]. Numerous studies concluded that obesity, as defined by a BMI>25 kg/m 2 negatively correlates with fertility potential, affecting ovulation, pregnancy rates and outcomes in natural and treated cycles [3,4]. There is also evidence that smoking negatively impacts on all areas of fertility from follicle development to fertilization and embryo cleavage.…”

Nutrition and reproduction: Is there evidence to support a “Fertility Diet” to improve mitochondrial function?

“…Studies of oocytes from obese women undergoing in vitro fertilization indicate that abnormal lipid accumulation and oxidative stress are associated with impaired oocyte development [9, 10]. Thus, there is a strong biological plausibility for seeking to improve mitochondrial function for fertility enhancement.…”