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Organocatalytic Enantioselective Friedel−Crafts Reaction of Pyrrole Derivatives with Imines

“…Pyrrolo[1,2- a ]pyrazine derivatives are medicinally important compounds reported to possess antiarrhythmic, antiamnesic, antihypoxic, psychotropic, antihypersensitive, and aldose reductase inhibitor activities . As a demonstration of the synthetic potential of the reactions we started with enantiomerically enriched 3k (92% ee).…”