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Abstract

The procedure based on commercially available 96-well microfilter plates is shown to be useful for determining logP of ionized drugs in a rapid and efficient way.

Use of voltammetry for in vitro equilibrium and transport studies of ionisable drugs

“…8 [57]. Ulmeanu et al used cyclic voltammetry and pH profiling to determine the partition coefficient of drugs using a commercial 96-well micro-filter plate system, which by nature requires only a small amount of the organic solvent and studied drug [58]. Other reports made significant contribution to the polarised membrane research, albeit not directly studying pharmaceutically relevant molecules [59][60][61][62][63].…”

Voltammetric Insights in the Transfer of Ionizable Drugs Across Biomimetic Membranes - Recent Achievements

“…Girault et al [30] developed a new electrochemical method for lipophilicity determination based on a liquid layer immobilized between two aqueous compartments. The method was found to be a successful tool for drug partition coefficient determinations across several water-organic phase interfaces, for example, for the monobase tetramethylaniline and the monoacid dinitrophenol.…”

Voltammetric study of the partitioning of macrolide antibiotics at the water/nitrobenzene interface. Relationship to the pharmacokinetic profiling of macrolides

“…The interfaces nitrobenzene/water, as well as 1,2-dichloroethane/water are good models for biological membranes, since they enable the rapid and precise determination of the electrochemical properties of ionised biological molecules. Both interfaces have already been used to probe the transfer of ionic drug compounds [14][15][16][17][18].…”