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Castlebury, Lisa A.; Sutherland, John B.; Tanner, Lisa A.; Henderson, Allison; Cerniglia, Carl E.

doi:10.1023/a:1008895421989

Cited by 48 publications

(16 citation statements)

References 10 publications

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“…Antibiotic Y, beauvericin, enniatins, and fusaric acid had weak antibiotic effects, in accordance with other studies [8,9,10,11,12,13,14,15,16,17,18,19,20,21]. Comparison of IC 50 or MIC values between different studies is never straightforward due to differences in methods, solubility and purity of the tested compounds.…”

Section: Resultssupporting

confidence: 86%

“…Members of the genus contain typically more than 30 different secondary metabolite gene clusters, of which several are species-specific [7]. Some secondary metabolites from Fusarium have been shown to possess an antibacterial effect, including antibiotic Y, beauvericin, enniatins and fusaric acid [8,9,10,11,12,13,14,15,16,17,18,19,20,21]. Others such as T-2 toxin, diacetoxyscirpenol and deoxynivalenol have not been shown to have an antibacterial effect [22].…”

Section: Introductionmentioning

confidence: 99%

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Fast Screening of Antibacterial Compounds from Fusaria

Søndergaard

Fredborg

Christensen

et al. 2016

Toxins

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Bio-guided screening is an important method to identify bioactive compounds from fungi. In this study we applied a fast digital time-lapse microscopic method for assessment of the antibacterial properties of secondary metabolites from the fungal genus Fusarium. Here antibacterial effects could be detected for antibiotic Y, aurofusarin, beauvericin, enniatins and fusaric acid after six hours of cultivation. The system was then used in a bio-guided screen of extracts from 14 different Fusarium species, which had been fractionated by HPLC. In this screen, fractions containing the red pigments aurofusarin and bikaverin showed effects against strains of Lactobacillus and Bifidobacterium. The IC50 for aurofusarin against Lactobacillus acidophilus was 8 µM, and against Bifidobacterium breve it was 64 µM. Aurofusarin only showed an effect on probiotic bacteria, leading to the speculation that only health-promoting bacteria with a positive effect in the gut system are affected.

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Section: Resultssupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Fast Screening of Antibacterial Compounds from Fusaria

Søndergaard

Fredborg

Christensen

et al. 2016

Toxins

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“…Beauvericin has a strong antibacterial activity against human, animal and plant pathogenic bacteria (Table 2) [29,30,31,32], with no selectively between Gram-positive and Gram-negative bacteria. Unlike other antibiotics (such as penicillin) that block the peptidoglycan biosynthesis of Gram-positive bacteria, the bacterial cell wall is not the antibacterial mode of action of beauvericin, although these antibiotics and beauvericin are both from amino acids that are produced by fungi.…”

Section: Bioactivity Of Beauvericinmentioning

confidence: 99%

Beauvericin, a Bioactive Compound Produced by Fungi: A Short Review

2012

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“…The danger of these mycotoxins presenting in cattle feed is that due to their high lipophilicity they are capable of bioaccumulation, and despite the relatively low acute toxicity to vertebrates, they have strong antibiotic properties against a wide range of microorganisms and can modify functional microflora of the rumen, thus violating the digestion of ruminants [76,77,78,79]. In addition to their antibiotic properties, enniatins and beauvericins have a cytotoxic effect on mammalian cells [80,81] and can inhibit the immune system [82,83,84].…”

Section: Discussionmentioning

confidence: 99%

Hydrophobized Reversed-Phase Adsorbent for Protection of Dairy Cattle against Lipophilic Toxins from Diet. Efficiensy In Vitro and In Vivo

Sotnichenko

Pantsov

Shinkarev

et al. 2019

Toxins

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The steady growth of inflammatory diseases of the udder in dairy cattle forces us to look for the causes of this phenomenon in the context of growing chemical pollution of the environment and feeds. Within the framework of this concept, an analysis was made of the polarity level of the three toxic impurity groups, which are commonly present in dairy cattle feeds. These impurities are presented by mycotoxins, polyaromatic hydrocarbons (PAH) and persistent organic pollutants (POP). It has been determined that 46% of studied mycotoxins (n = 1500) and 100% of studied polyaromatic hydrocarbons (n = 45) and persistent organic pollutants (n = 55) are lipophilic compounds, prone to bioaccumulation. A comparative evaluation of the sorption capacity of four adsorbents of a different nature and polarity with respect to the simplest PAH, naphthalene and lipophilic estrogenic mycotoxin, zearalenone in vitro has been carried out. The highest efficiency in these experiments was demonstrated by the reversed-phase polyoctylated polysilicate hydrogel (POPSH). The use of POPSH in a herd of lactating cows significantly reduced the transfer of aldrin, dieldrin and heptachlor, typical POPs from the “dirty dozen”, to the milk. The relevance of protecting the main functional systems of animals from the damaging effects of lipophilic toxins from feeds using non-polar adsorbents, and the concept of evaluating the effectiveness of various feed adsorbents for dairy cattle by their influence on the somatic cell count in the collected milk are discussed.

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Cited by 48 publications

References 10 publications

Fast Screening of Antibacterial Compounds from Fusaria

Fast Screening of Antibacterial Compounds from Fusaria

Beauvericin, a Bioactive Compound Produced by Fungi: A Short Review

Hydrophobized Reversed-Phase Adsorbent for Protection of Dairy Cattle against Lipophilic Toxins from Diet. Efficiensy In Vitro and In Vivo

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