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Ferreira, Cláudio dos Santos; Martins, Patricia Silveira; Demicheli, Cynthia; Brochu, Christian; Ouellette, Marc; Frézard, Frédéric

doi:10.1023/a:1022823605068

Cited by 126 publications

(41 citation statements)

References 20 publications

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“…A marine macroalga, Sargassum sp., was the first reported organism able to reduce Sb(V) in seawater (59). In the treatment of leishmaniasis, several studies suggested that Sb(V), when used as a prodrug medicine, might be reduced in both the vertebrate host and the parasites (60)(61)(62)(63). However, the knowledge of bacterial Sb(V) reduction is limited.…”

Section: Microbial Antimony Cyclementioning

confidence: 99%

Microbial Antimony Biogeochemistry: Enzymes, Regulation, and Related Metabolic Pathways

Wang

Oremland

et al. 2016

Appl Environ Microbiol

163

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e Antimony (Sb) is a toxic metalloid that occurs widely at trace concentrations in soil, aquatic systems, and the atmosphere. Nowadays, with the development of its new industrial applications and the corresponding expansion of antimony mining activities, the phenomenon of antimony pollution has become an increasingly serious concern. In recent years, research interest in Sb has been growing and reflects a fundamental scientific concern regarding Sb in the environment. In this review, we summarize the recent research on bacterial antimony transformations, especially those regarding antimony uptake, efflux, antimonite oxidation, and antimonate reduction. We conclude that our current understanding of antimony biochemistry and biogeochemistry is roughly equivalent to where that of arsenic was some 20 years ago. This portends the possibility of future discoveries with regard to the ability of microorganisms to conserve energy for their growth from antimony redox reactions and the isolation of new species of "antimonotrophs."

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Section: Microbial Antimony Cyclementioning

confidence: 99%

Microbial Antimony Biogeochemistry: Enzymes, Regulation, and Related Metabolic Pathways

Wang

Oremland

et al. 2016

Appl Environ Microbiol

163

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“…Abiotic Sb V reduction has been much less studied. It is well known that Sb V is reduced by thiol-containing ligands [96,97] and, for instance, cysteine is widely used as a Sb V pre-reductant in HG methods, but the extent of such reduction by thiol compounds in real environmental systems is unknown. Abiotic reduction of Sb V by green rust [98,99] and magnetite and mackinawite [100] have been described recently.…”

Section: Presence Of Thermodynamically Unstable Speciesmentioning

confidence: 99%

Antimony in the environment: knowns and unknowns

2009

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Environmental context. Antimony first attracted public attention in the mid-1990s amid claims that it was involved in Sudden Infant Death Syndrome. A substantial number of papers have now been published on the element and its behaviour in the natural environment. However, many key aspects of the environmental chemistry of antimony remain poorly understood. These include critical areas such as its ecotoxicology, its global cycling through different environmental compartments, and what chemical form it takes in different environments. More focussed research would help the situation. The present review highlights several areas of environmental antimony chemistry that urgently need to be addressed.Abstract. The objective of the present article is to present a critical overview of issues related to the current state of knowledge on the behaviour of antimony in the environment. It makes no attempt to systematically review all published data. However, it does provide a list of the main published reviews on antimony and identifies subjects where systematic reviews are needed. Areas where our knowledge is strong -and the corresponding gaps -in subjects ranging from total concentrations and speciation in the various environmental compartments, to ecotoxicity, to cycling between compartments, are discussed, along with the underlying research. Determining total antimony no longer poses a problem for most environmental samples but speciation measurements remain challenging throughout the process, from sampling to analysis. This means that the analytical tools still need to be improved but experience shows that, to be useful in practice, this should be directly driven by the requirements of laboratory and field measurements. Many different issues can be identified where further research is required, both in the laboratory and in the field, the most urgently needed studies probably being: (i) long-term spatial and temporal studies in the different environmental compartments in order to collect the data needed to establish a global biogeochemical cycle; (ii) laboratory studies of antimony interactions with potential natural binders; (iii) reliable ecotoxicological studies. Montserrat Filella is a chemist and teaches Environmental Chemistry at the University of Geneva, Switzerland. Her main research interests focus on the understanding of the physicochemical processes regulating the behaviour of chemical components in environmental and biological compartments, mainly by combining computer modelling with field and laboratory measurements. The three main axes of her research concern the study of: colloids in natural waters, natural organic matter (quantification and interaction with trace elements) and Group 15 elements. She is also interested in other topics

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“…Berman et al (4) and Demicheli et al (5) proposed that this drug interferes with the bioenergetic process of Leishmania amastigotes, forming stable complexes with ribonucleosides, which interfere with the parasite's fatty acid ␤-oxidation and glycolysis, promoting the depletion of intracellular ATP levels. Another hypothesis suggests that Sb V acts as a prodrug that is transformed into the more toxic trivalent form (Sb III ) to exert its antileishmanial activity (6)(7)(8)(9). In fact, some studies indicate that Sb III production in vivo is responsible for both therapeutic activity and antimony toxicity (10)(11)(12).…”

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confidence: 99%

Meglumine Antimoniate (Glucantime) Causes Oxidative Stress-Derived DNA Damage in BALB/c Mice Infected by Leishmania (Leishmania) infantum

Moreira

Jesus

Soares

et al. 2017

Antimicrob Agents Chemother

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Leishmaniasis is a neglected tropical disease caused by Ͼ20 species of the protozoan parasite Leishmania. Meglumine antimoniate (Glucantime) is the firstchoice drug recommended by the World Health Organization for the treatment of all types of leishmaniasis. However, the mechanisms of action and toxicity of pentavalent antimonials, including genotoxic effects, remain unclear. Therefore, the mechanism by which meglumine antimoniate causes DNA damage was investigated for BALB/c mice infected by Leishmania (Leishmania) infantum and treated with meglumine antimoniate (20 mg/kg for 20 days). DNA damage was analyzed by a comet assay using mouse leukocytes. Furthermore, comet assays were followed by treatment with formamidopyrimidine-DNA glycosylase and endonuclease III, which remove oxidized DNA bases. In addition, the activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in the animals' sera were assessed. To investigate mutagenicity, we carried out a micronucleus test. Our data demonstrate that meglumine antimoniate, as well as L. infantum infection, induces DNA damage in mammalian cells by the oxidation of nitrogenous bases. Additionally, the antileishmanial increased the frequency of micronucleated cells, confirming its mutagenic potential. According to our data, both meglumine antimoniate treatment and L. infantum infection promote oxidative stress-derived DNA damage, which promotes overactivation of the SOD-CAT axis, whereas the SOD-GPx axis is inhibited as a probable consequence of glutathione (GSH) depletion. Finally, our data enable us to suggest that a meglumine antimoniate regimen, as recommended by the World Health Organization, would compromise GPx activity, leading to the saturation of antioxidant defense systems that use thiol groups, and might be harmful to patients under treatment.

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Cited by 126 publications

References 20 publications

Microbial Antimony Biogeochemistry: Enzymes, Regulation, and Related Metabolic Pathways

Microbial Antimony Biogeochemistry: Enzymes, Regulation, and Related Metabolic Pathways

Antimony in the environment: knowns and unknowns

Meglumine Antimoniate (Glucantime) Causes Oxidative Stress-Derived DNA Damage in BALB/c Mice Infected by Leishmania (Leishmania) infantum

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