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Hassan, Rocı́o; White, Lídia R; Stefanoff, Cláudio Gustavo; Oliveira, Deílson Elgui de; Felisbino, Fabricio E; Klumb, Claudete Esteves; Bacchi, Carlos E.; Seuánez, Héctor N.; Zalcberg, Ilana

doi:10.1186/1746-1596-1-17

Cited by 58 publications

(26 citation statements)

References 31 publications

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“…In another study more than 95% concordance was detected between PCR results and EBER-ISH for detection of EBV (26, 27). Leong et al (21, 28) suggested that the EBER-ISH method was the most sensitive method for EBV detection.…”

Section: Discussionmentioning

confidence: 89%

Comparison Between Presence of Epstein Barr Virus in Nodal and Extra Nodal Diffuse Large B Cell Lymphoma of Head and Neck, an Iranian Experience

Ashraf¹,

Makarempour²,

Monabati³

et al. 2012

Iran Red Crescent Med J

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BackgroundEpstein Barr Virus (EBV) is one of the most common viral infections in human population. EBV has a significant role in pathogenesis of Hodgkin's lymphoma, Burkitt's lymphoma and nasopharyngeal carcinoma. The role of EBV in non-Hodgkin’s lymphoma, diffuse large B cell (NHL - DLBL) in the head and neck is controversial.ObjectivesThe purpose of this study is to find out the difference between the presence of Epstein Barr virus in nodal and extra nodal lymphoma of head and neck.Patients and MethodsA total of 30 cases of DLBL in two separate groups were collected from pathology department. The first group was consisted of 15 patients with DLBL of neck lymph node and the other was consisted of 15 patients with extra nodal DLBL of head and neck mainly in palatine tonsil. Both immune-histo-chemical (IHC) study and polymerase chain reaction (PCR) for detection of late membrane antigen (LMP) were performed on formalin fixed paraffin embedded tissue.ResultsAll 30 cases were negative for EBV in IHC method. But in PCR method, 10% of patients were positive for LMP gene. There were 2 positive cases in nodal lymphoma and 1 positive case in extra nodal lymphoma group.ConclusionsCompare with PCR method, it seems that IHC is not a sensitive method for detection of EBV. Overall, the finding of EBV in NHL depends on site, type of lymphoma and the detection method.

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Section: Discussionmentioning

confidence: 89%

Comparison Between Presence of Epstein Barr Virus in Nodal and Extra Nodal Diffuse Large B Cell Lymphoma of Head and Neck, an Iranian Experience

Ashraf¹,

Makarempour²,

Monabati³

et al. 2012

Iran Red Crescent Med J

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“…This corroborated findings in a Chinese study in which the rate of EBV detection in NHL was also higher (42.6%) than that of HL (26.3%), (p=0.213) [ 34 ]. Despite the fact that many studies confirm a strong association between EBV and lymphomas, the detection of EBV has not produced consistent results due to biological heterogeneity of the virus and diversity of lymphoma subtypes [ 6 , 9 ].…”

Section: Discussionmentioning

confidence: 99%

“…Older adults and children who are EBV-positive have a poor prognosis, possibly reflecting a poor immune status, which in turn means that these patients may tolerate the disease and its treatment less effective [ 8 ]. Making use of EBV association with lymphomas for clinical purposes and therapeutic treatment is of interest [ 9 ]. Therefore, the aim of this study was to provide evidence for the presence of EBV in lymphomas diagnosed at the University Teaching Hospital in Lusaka, Zambia.…”

Section: Introductionmentioning

confidence: 99%

Evidence of EBV infection in lymphomas diagnosed in Lusaka, Zambia

Kafita¹,

Kaile²,

Malyangu³

et al. 2018

Pan Afr Med J

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IntroductionEpstein-Barr virus (EBV) is a ubiquitous virus that infects more than 90% of the world's population, and is implicated in lymphoma pathogenesis. However, in Zambia during the diagnosis of these lymphomas, the association of the virus with the lymphomas is not established. Since most patients with lymphomas have poor prognosis, the identification of the virus within the lymphoma lesion will allow for more targeted therapy. The aim of this study was to provide evidence of the presence of the EBV in lymphomas diagnosed at the University Teaching Hospital (UTH) in Lusaka, Zambia.MethodsOne hundred and fifty archival formalin-fixed paraffin embedded suspected lymphoma tissues stored over a 4-year period in the Histopathology Laboratory at the UTH in Lusaka, Zambia, were analysed. Histological methods were used to identify the lymphomas, and the virus was detected using Polymerase Chain Reaction (PCR). Subtyping of the virus was achieved through DNA sequencing of the EBNA-2 region of the viral genome. Chi square or fisher's exact test was used to evaluate the association between EBV status, type of lymphoma and gender.ResultsThe majority of the lymphomas identified were non-Hodgkin's lymphoma (NHL) (80%) followed by Hodgkin's lymphoma (HL) (20%). EBV was detected in 51.8% of the cases, 54.5% of which were associated with NHL cases, while 40.9% associated with HL cases. The predominant subtype of the virus in both types of lymphomas was subtype 1. One of the lymphoma cases harboured both subtype 1 and 2 of the virus.ConclusionThis study showed that EBV is closely associated with lymphomas. Therefore, providing evidence of the presence of the virus in lymphoma tissues will aid in targeted therapy. To our knowledge this is the first time such data has been generated in Zambia.

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“…Copy number range of 1 to 50 of EBV DNA may be detected in a healthy person infected with EBV in white blood cells (WBC) [122]. PCR and real-time PCR sensitivity and specificity vary based on detection methods as well as laboratory to laboratory practise [118, 123, 124]. …”

Section: Ebv Detection Methodsmentioning

confidence: 99%

Status of Epstein-Barr Virus Coinfection withHelicobacter pyloriin Gastric Cancer

Singh

Jha

2017

Journal of Oncology

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Epstein-Barr virus is a ubiquitous human herpesvirus whose primary infection causes mononucleosis, Burkett's lymphoma, nasopharyngeal carcinoma, autoimmune diseases, and gastric cancer (GC). The persistent infection causes malignancies in lymph and epithelial cells. Helicobacter pylori causes gastritis in human with chronic inflammation. This chronic inflammation is thought to be the cause of genomic instability. About 45%-word population have a probability of having both pathogens, namely, H. pylori and EBV. Approximately 180 per hundred thousand population is developing GC along with many gastric abnormalities. This makes GC the third leading cause of cancer-related death worldwide. Although lots of research are carried out individually for EBV and H. pylori, still there are very few reports available on coinfection of both pathogens. Recent studies suggested that EBV and H. pylori coinfection increases the occurrence of GC as well as the early age of GC detection comparing to individual infection. The aim of this review is to present status on coinfection of both pathogens and their association with GC.

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Cited by 58 publications

References 31 publications

Comparison Between Presence of Epstein Barr Virus in Nodal and Extra Nodal Diffuse Large B Cell Lymphoma of Head and Neck, an Iranian Experience

Comparison Between Presence of Epstein Barr Virus in Nodal and Extra Nodal Diffuse Large B Cell Lymphoma of Head and Neck, an Iranian Experience

Evidence of EBV infection in lymphomas diagnosed in Lusaka, Zambia

Status of Epstein-Barr Virus Coinfection withHelicobacter pyloriin Gastric Cancer

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