Comparison Between Presence of Epstein Barr Virus in Nodal and Extra Nodal Diffuse Large B Cell Lymphoma of Head and Neck, an Iranian Experience

Ashraf, Mohammad Javad; Makarempour, Alireza; Monabati, Ahmad; Azarpira, Negar; Khademi, Bijan; Hakimzadeh, Afsoon; Abedi, Elham; Valibeigi, Bita

doi:10.5812/ircmj.1302

Cited by 10 publications

(19 citation statements)

References 32 publications

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“…The study results indicated higher positive results for these antibodies by ELISA in ALL group. Also, in the study conducted by Ashraf et al, (2012) presence of EBV, LMP gene were investigated in diffuse large B cell (DLBL) patients by Immune-Histo-Chemical (IHC) and PCR. The results reveal 10% prevalence of LMP by PCR in DLBL patients.…”

Section: Discussionmentioning

confidence: 99%

Molecular Epidemiology of Epstein-Barr virus (EBV) in Patients with Hematologic Malignancies

Tabibzadeh

Niya

Esghaei

et al. 2020

Asian Pac J Cancer Prev

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Section: Discussionmentioning

confidence: 99%

Molecular Epidemiology of Epstein-Barr virus (EBV) in Patients with Hematologic Malignancies

Tabibzadeh

Niya

Esghaei

et al. 2020

Asian Pac J Cancer Prev

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“…The rate of EBV detection in this study was found to be high, and was similar to a Nigerian study which reported 54.5% EBV-positivity in all lymphomas [ 32 ]. This can be attributed to a similarity in the types of lymphomas and subtypes evaluated, as well as the extent of immune suppression of the study population [ 33 ]. The EBV positivity rate in NHL was slightly higher than that in HL, although the difference was not statistically significant.…”

Section: Discussionmentioning

confidence: 99%

“…The rate of EBV positivity for NHL cases in this study was similar to those reported in Brazil, Uganda and Nigeria, which reported rates from 54.5% to 79.8% [ 9 , 22 , 32 ]. This similarity can be ascribed to the anatomical site or types of lymphomas evaluated [ 33 ]. The rate of EBV in lymphomas is also dependent on the overall rate of EBV infection in a specific geographical region.…”

Section: Discussionmentioning

confidence: 99%

Evidence of EBV infection in lymphomas diagnosed in Lusaka, Zambia

Kafita¹,

Kaile²,

Malyangu³

et al. 2018

Pan Afr Med J

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IntroductionEpstein-Barr virus (EBV) is a ubiquitous virus that infects more than 90% of the world's population, and is implicated in lymphoma pathogenesis. However, in Zambia during the diagnosis of these lymphomas, the association of the virus with the lymphomas is not established. Since most patients with lymphomas have poor prognosis, the identification of the virus within the lymphoma lesion will allow for more targeted therapy. The aim of this study was to provide evidence of the presence of the EBV in lymphomas diagnosed at the University Teaching Hospital (UTH) in Lusaka, Zambia.MethodsOne hundred and fifty archival formalin-fixed paraffin embedded suspected lymphoma tissues stored over a 4-year period in the Histopathology Laboratory at the UTH in Lusaka, Zambia, were analysed. Histological methods were used to identify the lymphomas, and the virus was detected using Polymerase Chain Reaction (PCR). Subtyping of the virus was achieved through DNA sequencing of the EBNA-2 region of the viral genome. Chi square or fisher's exact test was used to evaluate the association between EBV status, type of lymphoma and gender.ResultsThe majority of the lymphomas identified were non-Hodgkin's lymphoma (NHL) (80%) followed by Hodgkin's lymphoma (HL) (20%). EBV was detected in 51.8% of the cases, 54.5% of which were associated with NHL cases, while 40.9% associated with HL cases. The predominant subtype of the virus in both types of lymphomas was subtype 1. One of the lymphoma cases harboured both subtype 1 and 2 of the virus.ConclusionThis study showed that EBV is closely associated with lymphomas. Therefore, providing evidence of the presence of the virus in lymphoma tissues will aid in targeted therapy. To our knowledge this is the first time such data has been generated in Zambia.

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“…Although the etiology is still unknown, however, environmental agents and viruses, especially EBV, or vaccination, have been proposed to play a role in the pathogenesis of LCH ( 3 , 4 ). The role of EBV, as the etiologic agent of several malignancies is known and Herpes viruses are shown to be responsible for persistent infection ( 9 , 11 , 12 ). In addition, EBV and CMV are considered to be responsible for the hemophagocytic syndromes in human, with several inherited immunodeficiencies ( 24 , 25 ).…”

Section: Discussionmentioning

confidence: 99%

“…A series of studies, from various parts of the world, have reported the association of Epstein-Barr virus (EBV) infection with several malignancies and LCH, representing a possible etiologic role or contribution to its pathophysiology ( 3 , 4 , 9 - 12 ). However, other studies have failed to support these findings and the possible etiologic role of EBV and other viruses in LCH remains debated ( 13 - 16 ).…”

Section: Introductionmentioning

confidence: 99%

Detection of Epstein-Barr Virus DNA in Langerhans Cell Histiocytosis

Khoddami

Nadji

Dehghanian

et al. 2015

Jundishapur J Microbiol

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Background:Langerhans cell histiocytosis (LCH) is a rare histiocytic proliferation of unknown etiology. It is characterized by granuloma-like proliferation of Langerhans-type dendritic cells and mainly affects young children. Although multiple investigators have suggested the possible role of viruses, such as Epstein-Barr virus (EBV), human herpesvirus-6 (HHV-6), Herpes simplex virus (HSV) types 1 and 2, and Cytomegalovirus (CMV) in the pathogenesis of LCH, it remains, however, debated.Objectives:The EBV infection is reported to be associated with LCH. Nevertheless, no report could be found about involved Iranian children in English medical literature. In this study, we investigated the presence of EBV in Iranian children with LCH.Patients and Methods:In this retrospective study, in which we investigated the prevalence of presence of EBV DNA in LCH, using paraffin-embedded tissue samples of 30 patients with LCH and 30 age and tissue-matched controls, who were operated for reasons other than infectious diseases (between the years 2002 and 2012), by real-time polymerase chain reaction (RT-PCR) method, in the department of pediatric pathology. No ethical issues arose in the study, because only the pathology reports were reviewed, retrospectively, and the patients were anonymous.Results:There was a significant difference in prevalence of EBV presence between patients and controls. The EBV was found by RT-PCR in 19 (63.33%) out of 30 patients and only in eight (26.7%) of 30 control samples. The P = 0.004, was calculated using chi-square test (OR: 4.75; 95% CI: 1.58 ‒ 14.25).Conclusions:Our study is the first investigation performed on patients with LCH and its possible association with EBV in Iran. Considering the P = 0.004, which is statistically significant, the findings do support the hypothesis of a possible role for EBV in the pathogenesis of LCH. These results are in accordance with several previous investigations, with positive findings.

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Comparison Between Presence of Epstein Barr Virus in Nodal and Extra Nodal Diffuse Large B Cell Lymphoma of Head and Neck, an Iranian Experience

Cited by 10 publications

References 32 publications

Molecular Epidemiology of Epstein-Barr virus (EBV) in Patients with Hematologic Malignancies

Molecular Epidemiology of Epstein-Barr virus (EBV) in Patients with Hematologic Malignancies

Evidence of EBV infection in lymphomas diagnosed in Lusaka, Zambia

Detection of Epstein-Barr Virus DNA in Langerhans Cell Histiocytosis

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