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Haroun, Mohammed; Hajer, I.; Mukhtar, Maowia M.; Ali, B. El Hag

doi:10.1023/a:1020239515020

Cited by 44 publications

(7 citation statements)

References 4 publications

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“…These results are similar to a study in Ethiopia, which reported a seroprevalence of 33% in sheep and 67% in goats in the 1990s, but another study a decade later found the seroprevalence to be 9% in goats and 13% in sheep (Abraham et al 2005; Roeder et al 1994). The difference was less in Sudan (51.9% compared to 67.2%) in studies conducted 10 years apart (Haroun et al 2002; Saeed et al 2010).…”

Section: Discussionmentioning

confidence: 92%

Serosurvey of peste des petits ruminants virus in small ruminants from different agro-ecological zones of Nigeria

Woma

Ekong²,

Bwala³

et al. 2016

Onderstepoort J Vet Res

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Peste des petits ruminants, caused by the peste des petits ruminants virus (PPRV), is a highly contagious and economically important transboundary viral disease of domestic and wild small ruminants and a major hindrance to small-ruminant production in Nigeria. The seroprevalence and distribution of PPRV antibodies in small ruminants in rural households, farms, live animal markets and slaughter slabs across the six different agro-ecological zones of Nigeria were determined. A total of 4548 serum samples from 3489 goats and 1059 sheep were collected in 12 states. A PPRV competitive enzyme-linked immunosorbent assay was used to test the samples and the data analysed with R statistical software version 3.0.1. The study animals included all ages and both sexes. The overall prevalence estimate of sera positive for PPRV antibodies was 23.16% (n = 1018 positive samples per 4548 total samples, 95% confidence interval: 21.79% - 24.57%). There were significant differences in the seroprevalence between the states (p = 0.001). Taraba State had the highest seroprevalence of 29.51%, whilst the lowest seroprevalence of 14.52% was observed in Cross River State. There were no significant differences in the PPRV seroprevalence between male and female animals (p = 0.571), age (p = 0.323) and between species (p = 0.639). These data indicate the current seroprevalence to PPRV in the small-ruminant population in Nigeria.

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Section: Discussionmentioning

confidence: 92%

Serosurvey of peste des petits ruminants virus in small ruminants from different agro-ecological zones of Nigeria

Woma

Ekong²,

Bwala³

et al. 2016

Onderstepoort J Vet Res

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“…We have shown that wild-type PPRV protects cattle against RPV challenge and that this group had significant anti-RPV antibodies and RPV-specific T cell responses not detected in the groups given either of two PPRV vaccines. It is known from many recent serum surveys ( 48 – 52 ) that PPRV circulating in the small ruminant population can subclinically infect cattle, giving rise to PPRV-specific antibodies in the sera. It is interesting to speculate whether such subclinical infections occurred in the past, affecting the spread of RPV, and similarly whether any of the extensive spread of PPRV in the last 15 years has been due to the eradication of RPV.…”

Section: Discussionmentioning

confidence: 99%

Protection of Cattle against Rinderpest by Vaccination with Wild-Type but Not Attenuated Strains of Peste des Petits Ruminants Virus

Holzer

Hodgson

Logan

et al. 2016

J Virol

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Although rinderpest virus (RPV) has been eradicated in the wild, efforts are still continuing to restrict the extent to which live virus is distributed in facilities around the world and to prepare for any reappearance of the disease, whether through deliberate or accidental release. In an effort to find an alternative vaccine which could be used in place of the traditional live attenuated RPV strains, we have determined whether cattle can be protected from rinderpest by inoculation with vaccine strains of the related morbillivirus, peste des petits ruminants virus (PPRV). Cattle were vaccinated with wild-type PPRV or either of two established PPRV vaccine strains, Nigeria/75/1 or Sungri/96. All animals developed antibody and T cell immune responses to the inoculated PPRV. However, only the animals given wild-type PPRV were protected from RPV challenge. Animals given PPRV/Sungri/96 were only partially protected, and animals given PPRV/Nigeria/75/1 showed no protection against RPV challenge. While sera from animals vaccinated with the vaccine strain of RPV showed cross-neutralizing ability against PPRV, none of the sera from animals vaccinated with any strain of PPRV was able to neutralize RPV although sera from animals inoculated with wild-type PPRV were able to neutralize RPV-pseudotyped vesicular stomatitis virus. IMPORTANCE Rinderpest virus has been eradicated, and it is only the second virus for which this is so. Significant efforts are still required to ensure preparedness for a possible escape of RPV from a laboratory or its deliberate release. Since RPV vaccine protects sheep and goats from PPRV, it is important to determine if the reverse is true as this would provide a non-RPV vaccine for dealing with suspected RPV outbreaks. This is probably the last in vivo study with live RPV that will be approved.

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“…On the other hand, the detection of PPRV antibodies in up to 14% of camels as well as the detection of PPRV, PPRV antigen and RNA in lung samples (see Section 4.2. PPRV-detection in camels) without the report of clinical signs in different field studies suggest that camels are susceptible to PPRV-infection but are resistance to PPRV-induced disease [11,53,60]. Clinical signs of PPR disease are generally not specific and differential diagnoses or concurrent diseases such as bluetongue (BT), food and mouth disease (FMD), contagious ecthyma (orf), contagious caprine pleuropneumonia (CCPP), pasteurellosis, heartwater, and coccidiosis have to be considered [18].…”

Section: Clinical Signs Associated With Pprv-infectionmentioning

confidence: 99%

Camelids and Cattle Are Dead-End Hosts for Peste-des-Petits-Ruminants Virus

Schulz

Fast

Wernery

et al. 2019

Viruses

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Peste-des-petits-ruminants virus (PPRV) causes a severe respiratory disease in small ruminants. The possible impact of different atypical host species in the spread and planed worldwide eradication of PPRV remains to be clarified. Recent transmission trials with the virulent PPRV lineage IV (LIV)-strain Kurdistan/2011 revealed that pigs and wild boar are possible sources of PPRV-infection. We therefore investigated the role of cattle, llamas, alpacas, and dromedary camels in transmission trials using the Kurdistan/2011 strain for intranasal infection and integrated a literature review for a proper evaluation of their host traits and role in PPRV-transmission. Cattle and camelids developed no clinical signs, no viremia, shed no or only low PPRV-RNA loads in swab samples and did not transmit any PPRV to the contact animals. The distribution of PPRV-RNA or antigen in lymphoid organs was similar in cattle and camelids although generally lower compared to suids and small ruminants. In the typical small ruminant hosts, the tissue tropism, pathogenesis and disease expression after PPRV-infection is associated with infection of immune and epithelial cells via SLAM and nectin-4 receptors, respectively. We therefore suggest a different pathogenesis in cattle and camelids and both as dead-end hosts for PPRV.

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Abstract: Detection of antibodies against peste des petits ruminants virus in sera of cattle, camels, sheep and goats in Sudan.

Cited by 44 publications

References 4 publications

Serosurvey of peste des petits ruminants virus in small ruminants from different agro-ecological zones of Nigeria

Serosurvey of peste des petits ruminants virus in small ruminants from different agro-ecological zones of Nigeria

Protection of Cattle against Rinderpest by Vaccination with Wild-Type but Not Attenuated Strains of Peste des Petits Ruminants Virus

Camelids and Cattle Are Dead-End Hosts for Peste-des-Petits-Ruminants Virus

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