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Sciences, A. N Nesmeyanov Institute of Organoelement Compounds N. M. KobelkovaRussian Academy of; Osipov, Sergey N.; Kolomiets, A. F.

doi:10.1023/a:1020964916405

Cited by 8 publications

(2 citation statements)

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“…Imines 59 , possessing three electron-withdrawing groups, are very reactive and the aza Diels-Alder reaction was achieved at low temperature in the presence of different dienes 60 , to produce the corresponding unsaturated piperidines 61 in good yields. It is worth mentioning that phosphonylimines were less reactive than sulfonylimines as the reaction has to be performed at higher temperature and longer reaction times were required (120 h for phosphonylimines versus 14 h for sulfonylimines) (Table 1) [48]. …”

Section: From Non-cyclic Substratesmentioning

confidence: 99%

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Synthesis of Substituted α-Trifluoromethyl Piperidinic Derivatives

Rioton¹,

Pardo²,

Cossy³

2017

Molecules

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A comprehensive survey of pathways leading to the generation of α-trifluoromethyl monocyclic piperidinic derivatives is provided (65 references). These compounds have been synthesized either from 6-membered rings e.g., pipecolic acid or lactam derivatives by introduction a trifluoromethyl group, from pyridine or pyridinone derivatives by reduction, and from 5-membered rings e.g., prolinol derivatives by ring expansion, from linear amines by cyclization or from dienes/dienophiles by [4 + 2]-cycloaddition.

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Section: From Non-cyclic Substratesmentioning

confidence: 99%

“…When the silyloxydiene 62 was involved in the aza Diels-Alder reaction, piperidinone 63 was isolated after acidic treatment (Scheme 21) [48]…”

Section: From Non-cyclic Substratesmentioning

confidence: 99%