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Thakur, N. L.; Anil, Arga Chandrashekar

doi:10.1023/a:1005485310488

Cited by 55 publications

(7 citation statements)

References 26 publications

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“…Extracts were broadly deterrent against isolates of marine bacteria; however, differences were noted in the chemical nature and antibiotic activity of extracts collected during January and May suggesting an environmental influence on the production of antibacterial compounds by the sponge. 234 In a similar study, 2-octaprenyl-1,4-hydroquinone 45 from Ircinia spinulosa was reported to inhibit the growth of marine fungi and bacteria. 211 Ircinin I 31 and II 32 from I. oros and 2-octaprenyl-1,4-hydroquinone 45 from I. spinulosa also inhibited the attachment of microalgae to experimental petri dishes.…”

Section: Spongesmentioning

confidence: 95%

Chemical mediation of interactions among marine organisms

2004

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Section: Spongesmentioning

confidence: 95%

Chemical mediation of interactions among marine organisms

2004

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“…Some didemnid ascidians exhibit an almost sterile surface with 0 to 1.5 × 10 2 cells cm −2 (Wahl and Lafargue, 1990). Epibacterial densities on sponge surfaces range from almost sterile (60 cells cm 2 : Crambe crambe,), over strongly reduced (3 to 4 × 10 4 cells cm −2 : Ircinia fasciculata , Spongia officinalis , Becerro et al, 1994) to “normally fouled” (6.93 × 10 6 cells cm 2 : Ceratoporella nicholsoni , Santavy et al, 1990; 7 to 15 × 10 6 Ircinia ramosa , Thakur and Anil, 2000). Corals may have low (5 × 10 5 cells cm −2 : various species, Koh, 1997) or remarkably high densities of epibiotic bacteria (8.3 × 10 8 cells cm −2 : Oculina patagonica ; Koren and Rosenberg, 2006).…”

Section: Bacterial Communities At the Surface Of Macroorganismsmentioning

confidence: 99%

The Second Skin: Ecological Role of Epibiotic Biofilms on Marine Organisms

Wahl¹,

Goecke²,

Labes³

et al. 2012

Front. Microbio.

382

314

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In the aquatic environment, biofilms on solid surfaces are omnipresent. The outer body surface of marine organisms often represents a highly active interface between host and biofilm. Since biofilms on living surfaces have the capacity to affect the fluxes of information, energy, and matter across the host’s body surface, they have an important ecological potential to modulate the abiotic and biotic interactions of the host. Here we review existing evidence how marine epibiotic biofilms affect their hosts’ ecology by altering the properties of and processes across its outer surfaces. Biofilms have a huge potential to reduce its host’s access to light, gases, and/or nutrients and modulate the host’s interaction with further foulers, consumers, or pathogens. These effects of epibiotic biofilms may intensely interact with environmental conditions. The quality of a biofilm’s impact on the host may vary from detrimental to beneficial according to the identity of the epibiotic partners, the type of interaction considered, and prevailing environmental conditions. The review concludes with some unresolved but important questions and future perspectives.

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“…The genus Lendenfeldia is known as a source of sulfated sterols [22] and metabolites from the Lendenfeldia species have anti-HIV, anti-tumor [23], anti-inflammatory, antifouling [24] activities but they lack antimicrobial activity [22]. Secondary metabolites of the genus Ircinia and Dysidea are prime candidates for further study to unveil biological metabolites with antibacterial activity (Figure 1) [15,[25][26][27]. In the search for new antimicrobial agents, we screened a set of marine extracts [28] to determine activity against antibiotic resistant microorganisms using a high-throughput screening (HTS) assay.…”

Section: Introductionmentioning

confidence: 99%

Identification of Bioactive Compounds from Marine Natural Products and Exploration of Structure-Activity Relationships (SAR)

Dinarvand

Spain

2021

Antibiotics

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Marine natural products (MNPs) have been an important and rich source for antimicrobial drug discovery and an effective alternative to control drug resistant infections. Herein, we report bioassay guided fractionation of marine extracts from sponges Lendenfeldia, Ircinia and Dysidea that led us to identify novel compounds with antimicrobial properties. Tertiary amines or quaternary amine salts: aniline 1, benzylamine 2, tertiary amine 3 and 4, and quaternary amine salt 5, along with three known compounds (6–8) were isolated from a crude extract and MeOH eluent marine extracts. The antibiotic activities of the compounds, and their isolation as natural products have not been reported before. Using tandem mass spectrometry (MS) analysis, potential structures of the bioactive fractions were assigned, leading to the hit validation of potential compounds through synthesis, and commercially available compounds. This method is a novel strategy to overcome insufficient quantities of pure material (NPs) for drug discovery and development which is a big challenge for pharmaceutical companies. The antibacterial screening of the marine extracts has shown several of the compounds exhibited potent in-vitro antibacterial activity, especially against methicillin-resistant Staphylococcus aureus (MRSA) with minimum inhibitory concentration (MIC) values between 15.6 to 62.5 microg mL-1. Herein, we also report structure activity relationships of a diverse range of commercial structurally similar compounds. The structure-activity relationships (SAR) results demonstrate that modification of the amines through linear chain length, and inclusion of aromatic rings, modifies the observed antimicrobial activity. Several commercially available compounds, which are structurally related to the discovered molecules, showed broad-spectrum antimicrobial activity against different test pathogens with a MIC range of 50 to 0.01 µM. The results of cross-referencing antimicrobial activity and cytotoxicity establish that these compounds are promising potential molecules, with a favourable therapeutic index for antimicrobial drug development. Additionally, the SAR studies show that simplified analogues of the isolated compounds have increased bioactivity.

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Untitled

Cited by 55 publications

References 26 publications

Chemical mediation of interactions among marine organisms

Chemical mediation of interactions among marine organisms

The Second Skin: Ecological Role of Epibiotic Biofilms on Marine Organisms

Identification of Bioactive Compounds from Marine Natural Products and Exploration of Structure-Activity Relationships (SAR)

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