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Resim, Sefa; M, Cek; Zg, Gürbüz; Fazlıoğlu, Adem; Çaşkurlu, Turhan; Ar, U; Sevın, Güven

doi:10.1023/a:1007132926635

Cited by 5 publications

(2 citation statements)

References 9 publications

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“…2 The incidence of prostatic diseases, BPH and carcinoma increases with age. 3 In physiological condition, PSA is present in very low concentration (0.1 to 4.0 ng/ml). PSA is prostate specific but not specific to prostate cancer.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Prostate specific antigen levels and its correlation with histopathological findings

2019

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Background: Prostate specific antigen is a tumor marker though is expressed by both normal and neoplastic prostate tissue. The absolute value of Prostate specific antigen is useful for determining the extent of prostate cancer and its treatment. Prostate specific antigen also increases in cases like Benign Prostatic Hyperplasia and prostatitis. The availability of Prostate specific antigen as a marker has encouraged its use to diagnose both cancer and cancer recurrences. Materials and methods: This is a cross sectional study conducted in a tertiary hospital over a period of two years. Cases of prostatic disease undergoing surgery during the study period were taken. Prostate specific antigen level of all these cases were correlated with clinical and histopathological findings. Results: A total of 51 cases of prostatic disease underwent surgery during the study period with the mean age of 66.57 ± 10.68 years. On histopathological examination, 70.6% had benign prostatic hyperplasia and 17.6% had prostatic adenocarcinoma. Prostate specific antigen level was <4 ng/ml in 45.1% cases and >20.1ng/ml in 15.7%. In case of carcinoma prostate, 88.9% had prostate specific antigen level > 20.1ng/ml and 11.1% had prostate specific antigen level in a range of 10.1- 20 ng/ml. In case of chronic prostatitis, 66.7% had prostate specific antigen level in a range of 4.1-10 ng/ml. However, in case of high grade prostatic intraepithelial neoplasia (HGPIN), 66.7% had PSA level <4 ng/ml. Conclusions: Strong correlation of prostate specific antigen levels of > 20.1 ng/ml with carcinoma prostate was seen.

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Section: Introductionmentioning

confidence: 99%

“…[6][7][8] PSA is the most useful tumor marker in diagnosis and first line test in screening. 3 PSA levels are influenced by the patient's age and prostatic size. In healthy elderly male with no evidence of prostatic cancer, PSA increases by 3.2% per year.…”

Section: Introductionmentioning

confidence: 99%