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Schneiderman, Eva; Perly, Bruno; Brooks, Elwood E.; Stalcup, Apryll M.

doi:10.1023/a:1020411511591

Cited by 4 publications

(1 citation statement)

References 33 publications

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“…16 In addition to binary complexes, the ternary CD com plexes containing two identical or different guest mol ecules can be formed. [17][18][19][20][21][22] However, there are much less data on the structures of such complexes than for binary complexes; to our knowledge, data on the dynamics of guest molecules in ternary complexes are totally missing. As regards construction of functional supramolecular sys tems, of particular interest is the preparation and investi gation of the CD based ternary complexes that contain guest molecules of two types, specifically, one functional molecule and one regulatory molecule, i.e., able to change the properties of the functional molecule, for example, the fluorescence yield, the catalytic activity, the redox potential, etc.…”

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Structure and molecular dynamics of the ternary complexes of cyclodextrins with spin-labeled indoles and hydrocarbons in the solid phase. ESR spectroscopy and quantum chemical calculations

et al. 2006

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The ternary inclusion complexes of two spin labeled pyrrolidine and piperidine contain ing indole derivatives (1 and 2, respectively) and two hydrocarbons, benzene and cyclohexane, with γ and β cyclodextrins (CD) (altogether eight complexes) were prepared and studied by ESR in the solid phase over a broad temperature range. For most ternary complexes, the hydrophobicity of the NO group environment is much higher than for binary complexes devoid of hydrocarbons. The rotational mobility of both spin labeled indoles in the ternary complexes of γ CD is much greater than in binary complexes of γ CD, which is due to transition to the stoichiometry 2γ CD-1(2)-C 6 H 6 (C 6 H 12 ) from 1 : 1 stoichiometry. The guest rotational mobility in the complexes with either of the CD is higher for 2 than for 1. The saturation transfer ESR spectra show that the rotational mobility of 1 in γ and β CD in the presence of C 6 H 6 or C 6 H 12 has a character of fast librations in an angular cone, whose amplitude increases with temperature, whereas for radical 2, the rotation occurs in the full solid angle. The structures and energies of all complexes were calculated for different modes of inclusion of guest molecules using the PM3 method with the standard set of parameters. The calculation results are in qualitative agreement with experimental data. The results demonstrate the possi bility of substantial modification of the molecular dynamics and hydrophobicity of the envi ronment of "functional" guest molecules by introducing a second regulatory guest molecule into the CD cavity.Studies of the inclusion complexes of cyclodextrins (CD) have aroused considerable interest in recent years. The solubility of guest molecules may increase by several orders of magnitude upon inclusion into the CD cavity; simultaneously, their physical and chemical properties considerably change. 1-10 The inclusion complexes with CD have been the subjects of numerous studies carried out by various methods (see, for example, Refs 1-7); however, important aspects of their structure and espe cially the dynamics of guest molecules in the CD cavi ties 8-12 remain obscure. The use of spin labeled guest molecules is a promising approach to the study of the structure and molecular dynamics of the inclusion com plexes. The ESR spectra of spin labels are highly sensitive to rotational dynamics over a broad range of correlation times and to the environment polarity and intermolecular contacts. 13a Previously, 14,15 we studied the structure and molecular dynamics of the binary complexes of spin la beled indole analogs containing piperidine and pyrrolidine radical fragments with β and γ CD in an aqueous solu tion and determined the stoichiometry, the binding con stants, the polarity of the environment, and the accessi bility of the reporter NO group of guest molecules for water soluble paramagnetic ions. In the solid phase where the same complexes form a dilute solid solution in the CD, the molecular dynamics of guest molecules in the β and γ CD cavities have been studied ov...

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confidence: 99%