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Abstract

Systemic administration of beta-casein heptapeptide beta-casomorphin-7 (YPFPGPI, 1 mg/kg daily) to 10-23-day-old albino rat pups produced delayed anxiolytic effects, which were more pronounced in female than in male rats. Experimental findings confirm our assumption on the important role of nutritional opioids in brain development in newborn mammals.

Effect of β-casomorphin-7 on DNA synthesis in cell populations of newborn albino rats

“…Previous observations showed that newborn child receives 20-25 mg exogenous opioids with 2 mg dietary casein [1]. Our study provides experimental support to the potential role of food components in vital activity of the organism.…”

“…The dose of this peptide (1 mg/kg) is comparable with the amount of dietary β-casomorphin, which enters the mammalian organism during early postnatal ontogeny [1,12]. The rats were subjected to single (day 4 of life) or 5-fold treatment with test peptide (days 2-6 of life).…”

“…Exogenous OP of milk proteins (casomorphins) play a major role in newborn mammals [1]. Published data show that casomorphins modify behavioral reactions and gastrointestinal function in the growing organism [1,13]. However, the effect of casomorphins on proliferative processes in tissues of newborn mammals remains unknown.…”

Audiogenic Epilepsy in Mice with Different Genotypes after Neonatal Treatments Enhancing Neurogenesis in Dentate Gyrus

“…It was confirmed by numerous recent experimental data on delayed effects of administration of some pharmacological agents to rat and mouse pups [3][4][5].…”

Influence of Human B-Casomorphin-7 on Specific Binding of 3H-Spiperone to the 5-HT2-Receptors of Rat Brain Frontal Cortex

“…It has been shown that they influence nociception [1,2], regulate maternal and infant behavior [3], and possess anxiolytic [4] and cardiotropic actions [5]. However, the mechanisms through which these peptide bioregulators affect different physiological functions are still unclear.…”