Effect of β-casomorphin-7 on DNA synthesis in cell populations of newborn albino rats

Maslennikova, N. V.; Сазонова, Е. Н.; Тимошин, С. С.

doi:10.1007/s10517-008-0052-3

Cited by 6 publications

(6 citation statements)

References 13 publications

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“…C: Administration (i.p.) of either: (a) BCM-4, (b) BCM-6, or (c) distilled water Single dose of either I or C with the following concentrations: 1 mg/kg, 5 mg/kg, or 20 mg/kg Neurological effect*: behavioural change (locomotor activity) Not reported 16 Maslennikova 2008 [ 37 ] Russia 42 new-born outbred albino rats, aged 2–4 days To evaluate the effect of BCM7 on DNA synthesis in cell populations (tissue) of new-born albino rats I: BCM-7 administration (i.p.) C: Administration (i.p.)…”

Section: Resultsmentioning

confidence: 99%

“…Chang et al found increased growth performance with the administration of BCM-7 and described the involved mechanisms in broiler chickens [ 24 ]. Similarly, one study showed that BCM-7 stimulated DNA synthesis in new-born rats [ 37 ]. Furthermore, Wei et al found no effect of BCM-7 on the heart rate of rats (acting as opioid agent) [ 22 ].…”

Section: Resultsmentioning

confidence: 99%

“…All studies included at least 3154 animals in total (min 6 animals and max 639 animals per study; five studies did not report the exact number of animals included [18][19][20][21][22]). Most studies administered BCM-7 as injection [18][19][20][21][22][23][24][25][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42] and ten studies administered it orally [25,[43][44][45][46][47][48][49][50][51]. Most studies provided BCM-7 alone, whereas three studies used a mix of BCM-fragments (including BCM-7) as intervention [25,44,50].…”

Section: Characteristics Of Studies Comparing Bcm-7 Vs Any Other Intervention(s)mentioning

confidence: 99%

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A1- and A2 beta-casein on health-related outcomes: a scoping review of animal studies

et al. 2021

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Purpose Food-derived bioactive peptides may influence important physiological functions. An important example is beta-casomorphins, which are opioid peptides derived from A1 beta-casein in bovine milk and have been associated to be risk factors for non-communicable diseases in humans. A1 and A2 beta-casein are different with respect to the release of bioactive peptides, in particular BCM-7. However, evidence from human studies is limited and could be complemented with evidence derived from animal studies. We conducted a scoping review to identify animal studies investigating the effects of A1 beta-casein or BCM-7 compared to A2 beta-casein or any other intervention on health-related outcomes. Methods We systematically searched for relevant studies in two electronic databases (Medline, Embase; last search performed March 2020). Two reviewers independently undertook study selection and data extraction of included references. Results were summarized tabularly and narratively. Results We included 42 studies investigating various animal models, including rats, mice, rabbits, and dogs. Six studies investigated health-related outcomes of A1- vs. A2 milk, while most studies (n = 36) reported on physiological properties (e.g., analgesic effect) of BCM-7 as an opioid peptide. Included studies were extremely heterogeneous in terms of the study population, type of intervention and dose, and type of outcome measures. Conclusions Only a few studies comparing the effects of A1- and A2 milk were identified. More studies addressing this research question in animal models are needed to provide essential information to inform research gaps. Results from future studies could eventually complement research for humans, particularly when the body of evidence remains uncertain as is the case in the A1- and A2 milk debate.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Characteristics Of Studies Comparing Bcm-7 Vs Any Other Intervention(s)mentioning

confidence: 99%

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A1- and A2 beta-casein on health-related outcomes: a scoping review of animal studies

et al. 2021

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“…Накопление метки составляло десятые и сотые доли процента от введенного количества, однако было вполне достоверным. Накопление метки не зависит прямо от количества введенного вещества, что, в определенной степени может свидетельствовать о существовании особой транспортной системы, которая играет значение в переносе β -КМ через ГЭБ [8,9,10].…”

Section: проникновение β-км через гематоэнцефалический барьерunclassified

The biological role of casomorphins (part 2): role in human pathology

Хавкин

Vasia²,

Novikova

2022

jour

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The second part of the review on casomorphins is devoted to the role of these biologically active peptides — products of phosphoprotein hydrolysis. Convincing data on the eff ect on the immune system, anti-oncogenic effect, on the motility and tone of smooth muscle fibers, the ability to control other aspects of the gastrointestinal tract activity—the transport function of the intestinal epithelium, water absorption, etc. The effect of β-casomorphins on the endocrine system, primarily on release of insulin and somatostatin. Particular attention should be paid to the question of the effect of β-casomorphins on the maternal organism during pregnancy and breastfeeding of the newborn. This is important because β-casomorphins can enter the central nervous system, being one of the factors in postpartum psychosis and depression. The study of the mechanisms of action of β-casomorphins will bring scientists closer to understanding the genesis and pathogenesis of a signifi cant spectrum of pathologies.

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“…[49] Modulation of gene expression of the regulatory peptides from G and D cells was also demonstrated and data from in situ hybridization studies indicated that BCM-7 affected gastrin gene expression indirectly by means of the paracrine action of somatostatin. [9] Maslennikova et al [50] have found that BCM-7 was responsible for ex-vivo activation (DNA synthesis) of proliferative processes in the myocardium and ectodermal and endodermal epithelium of newborn rats. Orally administered BCM-7 has been demonstrated to influence postprandial metabolism by stimulating secretion of insulin.…”

Section: Functional Importance Of Bcm-7mentioning

confidence: 99%

Impact of Milk Derived β-Casomorphins on Physiological Functions and Trends in Research: A Review

Haq

Kapila

Shandilya

et al. 2014

International Journal of Food Properties

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β-Casomorphins are a group of opioid peptides released during gastrointestinal digestion or food processing from the β-casein of milk protein. Consequently, milk can be divided into A1 and A2 "like" groups depending upon the presence or absence of proline or histidine at the 67th position of β-casein. A1 "like" milk is postulated to be a source of BCM-7 as histidine allows the cleavage at this position, while A2 "like" milk has proline that resists the hydrolysis. On one hand, BCM-7 has been implicated as a risk factor for cardiovascular diseases, type I diabetes, and neurological disorders. On the other hand, various physiological effects of these peptides have also been documented, i.e., secretion of mucus, increased activity of superoxide dismutase and catalase, increased levels of prolactin, and analgesic role. In addition, many evidences correlate these peptides with various immunological functions, such as development of innate immunity, lymphocyte proliferation and cellular immunity, role in autoimmune diseases, histamine release, and allergy. In conclusion, the role of β-casomorphins in physiological functions remains controversial and more research with improved diagnostic techniques is needed to unravel the mechanism and study physiological functions of β-casomorphins. Thus, health-related aspects of β-casomorphins (positive, negative, and immunological impacts) have been comprehensively reviewed in this article.

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Effect of β-casomorphin-7 on DNA synthesis in cell populations of newborn albino rats

Cited by 6 publications

References 13 publications

A1- and A2 beta-casein on health-related outcomes: a scoping review of animal studies

A1- and A2 beta-casein on health-related outcomes: a scoping review of animal studies

The biological role of casomorphins (part 2): role in human pathology

Impact of Milk Derived β-Casomorphins on Physiological Functions and Trends in Research: A Review

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