Untitled

Keller, A. Scott; Bouldin, Molly B; Drage, Lisa A.; Hauser, Stephen C.; Davis, Mark D.P.

doi:10.1023/a:1022805329847

Cited by 11 publications

(4 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In all cases, UC preceded LABD onset by a median of 6.5 years. In addition, a few single cases of LABD associated with UC have been reported ( 191 , 207 – 211 ) (Table 5 ). The reason for this association is unclear, but alteration in colonic mucosal B cell and IgA production may play a pivotal role in LABD onset.…”

Section: Humoral Es In Autoimmune Bullous Diseasesmentioning

confidence: 99%

Humoral Epitope Spreading in Autoimmune Bullous Diseases

Didona

Zenzo

2018

Front. Immunol.

View full text Add to dashboard Cite

Autoimmune blistering diseases are characterized by autoantibodies against structural adhesion proteins of the skin and mucous membranes. Extensive characterization of their autoantibody targets has improved understanding of pathogenesis and laid the basis for the study of antigens/epitopes diversification, a process termed epitope spreading (ES). In this review, we have reported and discussed ES phenomena in autoimmune bullous diseases and underlined their functional role in disease pathogenesis. A functional ES has been proposed: (1) in bullous pemphigoid patients and correlates with the initial phase of the disease, (2) in pemphigus vulgaris patients with mucosal involvement during the clinical transition to a mucocutaneous form, (3) in endemic pemphigus foliaceus, underlining its role in disease pathogenesis, and (4) in numerous cases of disease transition associated with an intermolecular diversification of immune response. All these findings could give useful information to better understand autoimmune disease pathogenesis and to design antigen/epitope specific therapeutic approaches.

show abstract

Section: Humoral Es In Autoimmune Bullous Diseasesmentioning

confidence: 99%

Humoral Epitope Spreading in Autoimmune Bullous Diseases

Didona

Zenzo

2018

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…Clear guidelines have not been established for treatment of UC complicated with LABD. Reported cases of UC complicated with LABD are shown in table 1 15 16 18 20–33. Since 2000, 18 cases have been reported.…”

Section: Discussionmentioning

confidence: 99%

Ulcerative colitis complicated with linear immunoglobulin A bullous dermatosis

et al. 2022

View full text Add to dashboard Cite

Linear immunoglobulin A (IgA) bullous dermatosis (LABD) is a rare disorder involving subepidermal blistering characterised by IgA deposition along the basement membrane. The clinical features of LABD are variable but can include bullae, vesicles and erythematous lesions. Histopathology reveals formation of subepidermal bullae and linearly deposition of IgA in the basement membrane of the epidermis. LABD has been reported as a rare complication of ulcerative colitis (UC). We report the case of a young woman with UC complicated by LABD. The latter manifested as vesicles with erythema on almost the entire body. A biopsy of the skin lesions revealed linear IgA deposits in the basement membrane according to a direct immunofluorescence assay. Prednisolone administration resulted in clinical remission of UC but poor improvement of skin lesions. Oral administration of diaminodiphenyl sulfone led to improvement of blisters. Thereafter, abdominal and skin symptoms did not recur and she was discharged from hospital.

show abstract

“…To our knowledge, ours is the fifth reported case of LABD in a patient with renal cell carcinoma. 1 , 2 , 3 , 4 The relationship between hematologic malignancies and LABD is more established than that of solid organ tumors. Although a study in 1990 of 70 British patients with LABD did not show an increased rate of solid organ tumors, 1 subsequent reports have challenged those findings.…”

Section: Discussionmentioning

confidence: 99%