Linear IgA bullous dermatosis associated with metastatic renal cell carcinoma

Yang, Cheng‐San; Robinson‐Bostom, Leslie; Landow, Shoshana

doi:10.1016/j.jdcr.2015.02.001

Cited by 9 publications

(6 citation statements)

References 6 publications

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“…Linear IgA dermatosis, characterized by subepidermal blisters and IgA deposition in the basement membrane, has been documented in advanced RCC. The data presented in the literature support the concept that linear IgA bullous dermatosis may be a paraneoplastic syndrome of solid tumors [111,112].…”

Section: Paraneoplastic Syndromes In Rccsupporting

confidence: 73%

The Cellular Stress and Cutaneous Manifestations in Renal Cell Carcinomas—A Narrative Review

Ene,

Nicolae,

Tampa

et al. 2024

JCM

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The carcinomas originating from the renal cortex are the most aggressive renal malignancies, with a high tendency for metastasis. Understanding the incidence of cutaneous manifestations caused by renal carcinomas is a challenge. In the first part, this article summarizes a series of factors that promote oncogenesis, invasiveness, and the ability of renal cell carcinoma (RCC) to develop secondary cutaneous manifestations. It is postulated that the cellular stress response is one of the leading causes of developing dermatological events induced by cancers located at distant sites. Furthermore, the paper provides an overview of cutaneous complications associated with renal cancer, categorized as malignant manifestations (metastases, synchronous or metachronous cutaneous malignancies associated with renal cancer), non-malignant indirect cutaneous manifestations associated with renal cancer, and treatment consequences. The data presented in this article suggest that recognizing certain cutaneous disorders could assist the physician in the early identification of renal neoplasms and could lead to a better prognosis.

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Section: Paraneoplastic Syndromes In Rccsupporting

confidence: 73%

The Cellular Stress and Cutaneous Manifestations in Renal Cell Carcinomas—A Narrative Review

Ene,

Nicolae,

Tampa

et al. 2024

JCM

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“…Waal et al reported a case of LABD in a patient with renal cell carcinoma and suggested an association between LABD and malignancies [35]. Yang et al reported a case of LABD in a patient with renal cell carcinoma and suggested a causal association between LABD and renal cell carcinoma based on remission after treatment for malignancy [36].…”

Section: Discussionmentioning

confidence: 99%

Linear IgA Bullous Dermatosis in Korea Using the Nationwide Health Insurance Database

Kim,

Kim

et al. 2024

JCM

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(1) Background: Linear immunoglobulin A bullous dermatosis (LABD) is a rare autoimmune, subepidermal blistering disease, characterized by linear IgA deposits along the epidermal basement membrane. LABD is idiopathic and is associated with medication and systemic autoimmune diseases. (2) Methods: We investigated the demographic characteristics, disease course, causative agents, and associated diseases in Korean patients with LABD. The Korean Health Insurance Review and Assessment Service database was used to obtain data. We identified 670 LABD cases between 2010 and 2022. (3) Results: The annual incidence of LABD was 1.3 per 100,000 persons, with a higher prevalence in individuals ≥60 years old. The patients were treated with dapsone for 30.7 ± 56.7 days, had 1.3 ± 0.7 hospital visits, and were hospitalized for 19.8 ± 19.7 days. Risk factors, including malignancy, commonly preceded LABD. Antibiotic use, specifically vancomycin and third-generation cephalosporins, was a risk factor. The mean age of LABD diagnosis was 55.9 ± 21.7 years. (4) Conclusion: This is the first published study to assess a nationwide cohort for LABD. The incidence of LABD was higher than that in other studies. Most case reports have linked LABD with the administration of specific antibiotics; however, this study shows there were more associations with other conditions.

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“…LABD is a rare, autoimmune blistering disorder characterized by a diffuse vesiculobullous eruption located mainly on the trunk, thighs, and face. LABD is usually an idiopathic disease, but it can be associated with medications,2, 3 lymphoproliferative disorders, carcinomas 4 and systemic diseases 5 . Adult-onset LABD typically occurs in patients older than 60 years and has a spontaneous remission rate of 30% 6 .…”

Section: Discussionmentioning

confidence: 99%

Linear IgA bullous dermatosis associated with metastatic renal cell carcinoma

Cited by 9 publications

References 6 publications

The Cellular Stress and Cutaneous Manifestations in Renal Cell Carcinomas—A Narrative Review

The Cellular Stress and Cutaneous Manifestations in Renal Cell Carcinomas—A Narrative Review

Linear IgA Bullous Dermatosis in Korea Using the Nationwide Health Insurance Database

Linear IgA bullous dermatosis successfully treated with omalizumab: A case report

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