Untitled

Abstract

From the age of 3 months until their natural deaths, female outbred Swiss-derived SHR mice were subcutaneously injected on 5 consecutive days every month with 0.1 ml of normal saline (control) or with 1.0 microg/mouse (approximately 30-40 microg/kg) of tetrapeptide Epitalon (Ala-Glu-Asp-Gly) dissolved in 0.1 ml saline. There were 54 mice in each group. The results of this study show that treatment with Epitalon did not influence food consumption, body weight or mean life span of mice. However, it slowed down the age-related switching-off of estrous function and decreased the frequency of chromosome aberrations in bone marrow cells (by 17.1%, P<0.05). It also increased by 13.3% the life span of the last 10% of the survivors (P<0.01) and by 12.3% the maximum life span in comparison with the control group. We also found that treatment with Epitalon did not influence total spontaneous tumor incidence, but inhibited the development of leukemia (6.0-fold), as compared with the control group. The data obtained suggest a geroprotector activity of Epitalon and the safety of its long-term administration in mice.

Polyphenolic drug composition based on benzenepolycarboxylic acids (BP-C3) increases life span and inhibits spontaneous tumorigenesis in female SHR mice

“…Some other compounds and drugs with geroprotective activity are also shown to postpone age-related switching-off of the estrous function in mice and rats: melatonin, polypeptide pineal preparation Epitalamin, synthetic tetrapeptide Ala-Glu-Asp-Gly, neuro-protective delta-sleep inducing peptide (DSIP, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu), antidiabetic bigunanides buformin, phenformin and metformin, mitochondria-targeted plastoquinon-containing anti-oxidant drug SkQ1 and some other [ 19 - 24 ]. Pharmacologically active compounds of different classes, with different biological efficacy and different specific mechanisms of action in relation to aging, can be considered as anti-aging drugs.…”

Empowering Melatonin Therapeutics with Drosophila Models

“…Epithalamin was found to be active in both its natural and synthetic form, the latter called epit(h)alon [174][175][176]. Besides lengthening the healthy life span, epithalamin could also reduce carcinogenesis, improve cardiovascular function, and protect retinal and brain function [174,[176][177][178][179][180][181][182][183][184][185][186][187]. Epithalamin heightened peroxide chemiluminescence found in the blood of 30-month-old rodent models and humans [173].…”

Peptide Regulation of Aging: 35-Year Research Experience

“…Low-molecular-weight peptides isolated from animal thymus (Thymalin) and epiphysis (Epithalamine) were studied on various biological models. These peptide preparations promoted a signifi cant prolongation of the mean and in many cases of the maximum life span of mice and rats in numerous experiments (Table 1) and inhibited aging of the reproductive system, motor activity, and physical endurance in these animals [1][2][3]5,6,[16][17][18][19][21][22][23]. A clear-cut correlation between the increase in the mean lifespan and the main indicator of cellular immunity (lymphocyte blast transformation reaction with phytohemagglutinin, characterizing the function of T-lymphocytes [17]), is worthy of note.…”