Empowering Melatonin Therapeutics with Drosophila Models

Millet-Boureima, Cassandra; Ennis, Caroline C.; Jamison, Jurnee; McSweeney, Shana; Park, Anna; Gamberi, Chiara

doi:10.3390/diseases9040067

Cited by 4 publications

(1 citation statement)

References 335 publications

(412 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have demonstrated that melatonin is essential for maintaining human circadian rhythm, sleep, mood, body temperature, appetite, and immunological responses ( Socaciu et al., 2020 ). Furthermore, antioxidant, anti-inflammatory, and other biological functions were also proven to be regulated by melatonin; thus, melatonin has been employed extensively for disease pathogenesis and drug development ( Millet-Boureima et al., 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Melatonin-mediated development and abiotic stress tolerance in plants

Pan

Li³

et al. 2023

Front. Plant Sci.

View full text Add to dashboard Cite

Melatonin is a multifunctional molecule that has been widely discovered in most plants. An increasing number of studies have shown that melatonin plays essential roles in plant growth and stress tolerance. It has been extensively applied to alleviate the harmful effects of abiotic stresses. In view of its role in regulating aspects of plant growth and development, we ponder and summarize the scientific discoveries about seed germination, root development, flowering, fruit maturation, and senescence. Under abiotic and biotic stresses, melatonin brings together many pathways to increase access to treatments for the symptoms of plants and to counteract the negative effects. It has the capacity to tackle regulation of the redox, plant hormone networks, and endogenous melatonin. Furthermore, the expression levels of several genes and the contents of diverse secondary metabolites, such as polyphenols, terpenoids, and alkaloids, were significantly altered. In this review, we intend to examine the actions of melatonin in plants from a broader perspective, explore the range of its physiological functions, and analyze the relationship between melatonin and other metabolites and metabolic pathways.

show abstract

Section: Introductionmentioning

confidence: 99%

Melatonin-mediated development and abiotic stress tolerance in plants

Pan

Li³

et al. 2023

Front. Plant Sci.

View full text Add to dashboard Cite

show abstract

Evolutionary formation of melatonin and vitamin D in early life forms: insects take centre stage

Kim,

Slominski,

Pyza

et al. 2024

Biological Reviews

View full text Add to dashboard Cite

Melatonin, a product of tryptophan metabolism via serotonin, is a molecule with an indole backbone that is widely produced by bacteria, unicellular eukaryotic organisms, plants, fungi and all animal taxa. Aside from its role in the regulation of circadian rhythms, it has diverse biological actions including regulation of cytoprotective responses and other functions crucial for survival across different species. The latter properties are also shared by its metabolites including kynuric products generated by reactive oxygen species or phototransfomation induced by ultraviolet radiation. Vitamins D and related photoproducts originate from phototransformation of ∆5,7 sterols, of which 7‐dehydrocholesterol and ergosterol are examples. Their ∆5,7 bonds in the B ring absorb solar ultraviolet radiation [290–315 nm, ultraviolet B (UVB) radiation] resulting in B ring opening to produce previtamin D, also referred to as a secosteroid. Once formed, previtamin D can either undergo thermal‐induced isomerization to vitamin D or absorb UVB radiation to be transformed into photoproducts including lumisterol and tachysterol. Vitamin D, as well as the previtamin D photoproducts lumisterol and tachysterol, are hydroxylated by cyochrome P450 (CYP) enzymes to produce biologically active hydroxyderivatives. The best known of these is 1,25‐dihydroxyvitamin D (1,25(OH)2D) for which the major function in vertebrates is regulation of calcium and phosphorus metabolism. Herein we review data on melatonin production and metabolism and discuss their functions in insects. We discuss production of previtamin D and vitamin D, and their photoproducts in fungi, plants and insects, as well as mechanisms for their enzymatic activation and suggest possible biological functions for them in these groups of organisms. For the detection of these secosteroids and their precursors and photoderivatives, as well as melatonin metabolites, we focus on honey produced by bees and on body extracts of Drosophila melanogaster. Common biological functions for melatonin derivatives and secosteroids such as cytoprotective and photoprotective actions in insects are discussed. We provide hypotheses for the photoproduction of other secosteroids and of kynuric metabolites of melatonin, based on the known photobiology of ∆5,7 sterols and of the indole ring, respectively. We also offer possible mechanisms of actions for these unique molecules and summarise differences and similarities of melatoninergic and secosteroidogenic pathways in diverse organisms including insects.

show abstract

Evidence for the Benefits of Melatonin in Cardiovascular Disease

Tobeiha

Jafari

Fadaei

et al. 2022

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

The pineal gland is a neuroendocrine gland which produces melatonin, a neuroendocrine hormone with critical physiological roles in the circadian rhythm and sleep-wake cycle. Melatonin has been shown to possess anti-oxidant activity and neuroprotective properties. Numerous studies have shown that melatonin has significant functions in cardiovascular disease, and may have anti-aging properties. The ability of melatonin to decrease primary hypertension needs to be more extensively evaluated. Melatonin has shown significant benefits in reducing cardiac pathology, and preventing the death of cardiac muscle in response to ischemia-reperfusion in rodent species. Moreover, melatonin may also prevent the hypertrophy of the heart muscle under some circumstances, which in turn would lessen the development of heart failure. Several currently used conventional drugs show cardiotoxicity as an adverse effect. Recent rodent studies have shown that melatonin acts as an anti-oxidant and is effective in suppressing heart damage mediated by pharmacologic drugs. Therefore, melatonin has been shown to have cardioprotective activity in multiple animal and human studies. Herein, we summarize the most established benefits of melatonin in the cardiovascular system with a focus on the molecular mechanisms of action.

show abstract

Empowering Melatonin Therapeutics with Drosophila Models

Cited by 4 publications

References 335 publications

Melatonin-mediated development and abiotic stress tolerance in plants

Melatonin-mediated development and abiotic stress tolerance in plants

Evolutionary formation of melatonin and vitamin D in early life forms: insects take centre stage

Evidence for the Benefits of Melatonin in Cardiovascular Disease

Contact Info

Product

Resources

About